Results 171 to 180 of about 2,738,308 (324)

Cytochrome P450-Mediated Metabolism of Antimycobacterial <i>N</i>α-Aroyl-<i>N</i>-aryl-phenylalanine Amides. [PDF]

ACS Infect Dis
Doering J, Meerz E, Seidel RW, Lang M, Kany AM, Auriola S, Juvonen RO, Raunio H, Goddard R, Zimmerman MD, Dartois V, Hirsch AKH, Dick T, Richter A.   +13 more
europepmc   +1 more source

Investigations Into the Metabolism and Elimination of Tesofensine in Human Urine

Drug Testing and Analysis, Volume 18, Issue 9, Page 1163-1173, September 2026.
This study investigated tesofensine metabolism and urinary elimination after a single 483 μg intake via a dietary supplement. In six volunteers, urine was collected up to 659 h. LC‐HRMS/MS identified four tentative metabolites; maximum urinary concentrations reached 4 ng/mL within 4–48 h.
O. Krug, A. Thomas, M. Thevis
wiley   +1 more source

Age (juvenile to aged) and sex effects on in vitro CYP2A6 enzyme activity in African green monkeys using nicotine and coumarin. [PDF]

Drug Metab Dispos
Gu W, Tyndale RF.
europepmc   +1 more source

Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The in‐silico data showed that fisetin binds stably with the autophagy receptors and synaptic density regulators. Further, in‐vitro data confirmed the restoration of Aβ1‐42 disrupted autophagy by fisetin. Fisetin restored the oxidative stress and ion channels, along with a reduction of AChE activity.
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh   +2 more
wiley   +1 more source

Investigation of Thymoquinone as an Inhibitor of CYP2C8/EET Axis. [PDF]

Chembiochem
Dhiman S, Manhas D, Jamwal A, Singh A, Kumar V, Vij B, Ojha PK, Singh SK, Ahmed Z, Nandi U.   +9 more
europepmc   +1 more source

Suzetrigine Is Not Expected to Have Clinically Relevant DDIs with Apixaban and Rivaroxaban Based on PBPK Modeling

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Suzetrigine (VX‐548) is a first‐in‐class, oral, non‐opioid, FDA‐approved analgesic for the treatment of moderate to severe acute pain. Based on Phase 1 clinical drug–drug interaction (DDI) studies, suzetrigine is a weak‐to‐moderate cytochrome P450 3A (CYP3A) inducer and thus has the potential to decrease exposure and impact efficacy of CYP3A ...
Guanyu Wang, Elizabeth Lakota, Bo Feng, Licong Jiang, Guiqing Liang, Brian Hare   +5 more
wiley   +1 more source

Design of aptamer peptides for immunomodulation. [PDF]

J Enzyme Inhib Med Chem
Chowdhury A, Shrestha P, Subramanian V, Mayandi V, Mahajan M, Jois SD.   +5 more
europepmc   +1 more source

In Vitro Metabolism of Medroxyprogesterone Acetate with Human Liver Microsome and Comparison with Rat,Minipig Liver Microsmes and Recombinant Human CYP3A4

, 2006
Objective: To study the metabolism of medroxyprogesterone acetate (MPA) in human liver microsomes and compare the metabolim profile with rat, minipig liver mcirosomes and recombinant human CYP3A4.
张江伟, 李巍, 刘勇, 杨凌
core  

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) steatotic liver disease special interest group position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction‐associated steatotic liver disease

Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 3, Page 555-576, September 2026.
Abstract Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common reason for elevated liver enzymes in children in Europe, affecting more than 5% of all children. Since the last iteration of this position paper, there have been substantial advances in our understanding of the disease.
Jake P. Mann, Sander Lefere, Maarten Buytaert, Anna Alisi, Cigdem Arikan, Jernej Brecelj, Rachel M. Brown, Irene Degrassi, Giulia Fiore, Emer Fitzpatrick, Sven Francque, Christian A. Hudert, Wojciech Janczyk, Lauren Johansen, Bart G. Koot, Anastasia Konidari, Eberhard Lurz, Claudia Mandato, Maria Mercadal‐Hally, Hadar Moran‐Lev, Antonella Mosca, Giusy Ranucci, Maria Rogalidou, Penelope C. Rose, Piotr Socha, Pietro Vajro, Elvira Verduci, Anita C. E. Vreugdenhil, Natalia Zavhorodnia, Aglaia Zellos, Ruth De Bruyne   +30 more
wiley   +1 more source

Discovery of Novel Small-Molecule Toll-like Receptor 2 Agonists via a Scaffold Hopping Strategy. [PDF]

ACS Med Chem Lett
Zhu Y, Wang L, Chen Y, Wang Y, Chen Z, Li Y, Zhang W.   +6 more
europepmc   +1 more source