Results 171 to 180 of about 34,918 (236)

Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach. [PDF]

J Med Chem
Valderrama K, Horlacher O, Publicola G, Eisenring P, Kienle M, Boarbi S, Kiass M, Korduláková J, Chatagnon J, Piveteau C, Leroux F, Savková K, Záhorszká M, Cantrelle FX, Lherbet C, Mourey L, Mikušová K, Mathys V, Aichholz R, Maveyraud L, Altmann KH, Hartkoorn RC.   +21 more
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Study on Phase I Metabolic Processes and Metabolite Biomarker Identification of Synthetic Cannabinoids 5F-ADB-PINACA and 5F-ADBICA in Human Liver Microsomes and Zebrafish Model. [PDF]

Molecules
Li H, Zheng H, Zhong S, Zhao Y, Lin J, Su H, Qian Z, Wang Y.   +7 more
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Investigation of the Relevance of CYP3A4 Inhibition on the Pharmacokinetics of the Novel P2X3 Antagonist Filapixant: Results of In Vitro Explorations and a Fixed-Sequence Clinical Trial with Itraconazole in Healthy Volunteers. [PDF]

Int J Mol Sci
Francke K, Rottmann A, Klein S, Höchel J, Friedrich C.   +4 more
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The Effects of Drugs on CYP3A Enzyme Activity and Protein Expression Through Ubiquitination Modification Regulation. [PDF]

Basic Clin Pharmacol Toxicol
Wang F, Gu X, Hong H, Xia Q, Zhang Y, Song Y, Li B, Fan P.   +7 more
europepmc   +1 more source

Drug-Metabolizing Enzymes in Human Keratinocytes and In Vitro Detection of Cytochrome P450-Mediated Phenolic Lamotrigine Metabolite. [PDF]

Chem Res Toxicol
Deck PN, Müller M, Glässner A, Vogel M, Steffens M, Heubach C, Fechner G, Becker K, Weindl G, Sachs B.   +9 more
europepmc   +1 more source

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Interaction of ranitidine with liver microsomes

Xenobiotica, 1982
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, T, Alebić-Kolbah, F, Kajfez, H H, Ruf   +3 more
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Metabolism of nitrosoacetoxymethylmethylamine in liver microsomes

Biochemical Pharmacology, 1981
Abstract The carcinogen nitrosoacetoxymethylmethylamine (NAMM)‡ was incubated with mouse liver microsomes. The decomposition rate of NAMM and the formation of methanol were determined. After addition of an NADPH-regenerating system, formaldehyde formation resulting from metabolic degradation of the methyl group of NAMM was measured.
K E, Appel, N, Frank, M, Wiessler
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Interaction of Cimetidine with Liver Microsomes

Xenobiotica, 1979
1. Ranitidine interacts with liver microsomes from rats pretreated with different inducers of cytochrome P-450 to produce substrate difference optical spectra with a peak at 426-429 nm and a trough at 390-400 nm. 2. Cytochrome P-450 reduced with dithionite in the presence of ranitidine produced substrate difference spectra with a peak at 447 nm. 3.
S, Rendić, V, Sunjić, R, Toso, F, Kajfez, H H, Ruf   +4 more
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Permeability of Liver Microsomal Membranes to Glucose

Biochemical and Biophysical Research Communications, 1996
The permeability of rat liver microsomes to glucose has been studied by using (14)C-labelled D-glucose and a light-scattering technique. 1) The microsomal intravesicular apparent isotope space for D-glucose (1mM; after 5 min incubation at 22 degrees C) was 2.34 microl/mg protein, i.e., approximately 72% of the apparent water space.
MARCOLONGO, P., FULCERI, R., GIUNTI, R., BURCHELL, A., BENEDETTI, A.   +4 more
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