Results 151 to 160 of about 2,738,308 (324)

Living donor liver transplantation for acute liver failure in pediatric patients caused by the ingestion of fireworks containing yellow phosphorus

, 2011
Yellow phosphorus is a protoplasmic toxicant that targets the liver. The ingestion of fireworks containing yellow phosphorus, either by children who accidentally consume them or by adults who are attempting suicide, often results in death due to acute ...
Işık, Burak, Selimoğlu, Mukadder Ayşe, Kayaalp, Cüneyt, Yılmaz, Sezai, Aydın, Cemalettin, Ara, Cengiz, Ateş, Mustafa, Yılmaz, Mehmet, Özgör, Dinçer, Dirican, Abuzer   +9 more
core   +1 more source

The spatial arrangement of esterases in the microsomal membrane [PDF]

, 1975
Gratzl, Manfred, Nastainczyk, W., Schwab, D.   +2 more
core   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Investigation Into the Metabolism and Elimination Behavior of RU 58841, and Its Influence on the Steroid Profile in Humans

Biomedical Chromatography, Volume 40, Issue 10, October 2026.
ABSTRACT RU 58841 is a nonsteroidal antiandrogen, developed for the treatment of androgen‐dependent conditions. This study aimed to characterize the human metabolism of RU 58841 for the first time and to assess its systemic exposure following topical administration.
Aylin Okutan, Oliver Krug, Gregor Fußhöller, Thomas Piper, Mario Thevis   +4 more
wiley   +1 more source

Drug‐Induced Liver Injury During Treatment With Tocilizumab: A Case Report of an Atypical Pattern Lesion

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Tocilizumab is an interleukin‐6 (IL‐6) receptor antagonist indicated for various rheumatologic conditions. While hepatotoxicity is a recognized adverse effect, it predominantly manifests as hepatocellular injury. We report a rare case of drug‐induced liver injury (DILI) presenting with a cholestatic pattern and cholangitis features in a 75 ...
Louis‐Edmond Barbaro, Nouha Ben Othman, Delphine Viard, Fanny Rocher, Elliot Ewig, Raja Mroue, Claire Amigues, Alexandre O. Gérard   +7 more
wiley   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, Volume 13, Issue 50, 7 September 2026.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Mechanistic Understanding of Protein–MOF Integration Through Surfactant‐Driven Interfacial Design

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals how surfactant‐driven interfacial design governs the assembly and stability of protein@MOF composites. Using lipid‐based nonionic surfactants, we modulate protein–MOF interactions to improve encapsulation efficiency, MOF crystallization, and catalytic performance.
Ehsan Rashidniyaghi, Mohammad Khavani, Carlie Coerver, Ruibin Liang, Raheleh Ravanfar   +4 more
wiley   +1 more source

Metabolism of 2-oxo-clopidogrel to the clopidogrel active H4 metabolite using human liver microsomes and its inhibitory effect on ADP-induced human platelet aggregation <i>ex vivo</i>: a confirmatory, placebo-controlled, parallel-group study. [PDF]

Front Cardiovasc Med
Schulz C, Braune S, Mrowietz C, Küpper JH, Jung F.   +4 more
europepmc   +1 more source

Synthesis and Hepatotoxicity Evaluation of Paeonol Clofibrate

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
CF‐Paeonol, a molecular hybrid of clofibric acid and paeonol, retains lipid‐lowering activity while producing markedly less hepatic injury than clofibrate (CF) in mice. Its benefits are accompanied by improved bile acid homeostasis, reduced oxidative stress and inflammation, decreased YY1 expression, and increased FXR expression, supporting molecular ...
Haoyu Tu, Ling Ding, Jing Zheng, Yichen Yang, Xin Chen, Yumiao Song, Xinyi Shi, Chuwen Wang, Xinya Xu, Jiping Liu, Yundong Xie   +10 more
wiley   +1 more source

Cross-Species Multitask Learning with Molecular and ADME Descriptors for Liver Microsomal Metabolic Stability. [PDF]

Comput Struct Biotechnol J
Seomun S, Yoo S.
europepmc   +1 more source