Results 151 to 160 of about 28,121 (229)

Physicochemical Characterization and Metabolites Identification of the Synthetic Cannabinoid MDMB-5'Br-PINACA Using <i>In Silico</i> and <i>In Vitro</i> Approaches. [PDF]

Chem Res Toxicol
Godoi AB, Antunes NJ, da Silva JCC, Cordeiro G, Castro TFD, Costa JL.   +5 more
europepmc   +1 more source

Structure-Based Drug Discovery of Non-SAM-Mimetic Bisubstrate Inhibitors against Nicotinamide <i>N</i>‑Methyltransferase. [PDF]

ACS Med Chem Lett
Yoshida S, Kondo N, Uehara S, Yoshimura N, Sako Y, Yamamoto S, Kitade M, Tachibana Y.   +7 more
europepmc   +1 more source

Discovery of <i>N</i>-Acetyltransferase 8-Like (NAT8L) inhibitors based on a <i>N</i>-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold. [PDF]

ACS Med Chem Lett
Nayeen MJ, Thomas AG, Kundu B, Carlyle E, Hin N, Hin P, Pal A, Paule J, Rais R, Slusher BS, Tsukamoto T.   +10 more
europepmc   +1 more source

Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies. [PDF]

ACS Med Chem Lett
Bouton J, Bretteville A, Tresadern G, Shaffer P, Austin N, Buijnsters P, Cedervall EP, Darville N, Fonteyn I, Leenaerts J, Lamenca CM, Mertens L, Peeters D, Velter AI, Roosbroeck YV, Ebneth A, Bartolomé JM, Trabanco AA, Oehlrich D.   +18 more
europepmc   +1 more source

Comprehensive Review on the Toxicity of Five Main AQ Constituents from Rhubarb: Mechanisms, Challenges and Future Perspectives. [PDF]

Drug Des Devel Ther
Yu L, Jiang Y, Li P, Wang J, Tang P, Zhao Y.   +5 more
europepmc   +1 more source

Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids. [PDF]

Proc Natl Acad Sci U S A
Tripathy SK, Mahapatra A, Saharan O, Chatterjee H, Sengupta N, Kamat S, Nair S, Mallik R.   +7 more
europepmc   +1 more source

Early ADME and Preliminary Toxicity Studies of I-152, an <i>N</i>-Acetyl-l-Cysteine/<i>S</i>-Acetylcysteamine Conjugate. [PDF]

Chem Res Toxicol
Bartoccini F, Valeri A, Gregori M, Masini S, Bruschi M, Goracci L, Fraternale A, Piersanti G.   +7 more
europepmc   +1 more source

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively. [PDF]

Pharmaceuticals (Basel)
Grangeon A, Arwood ML, Thacker D, Gaudette F, Turgeon J, Michaud V.   +5 more
europepmc   +1 more source

First-in-Class Covalent Inhibitors of PFKFB3: Discovery and Characterization in PDAC Models. [PDF]

J Med Chem
Fiore A, Scarano A, Antonini G, Corfù AI, Sicuro L, Faggiano S, Celesia A, Tesoriero C, Pacchiana R, Vettori A, Arslanbaeva L, Minucci S, Pallavicini I, Mollica L, Tamborini L, Donadelli M, Conti P, Bruno S, Borsari C.   +18 more
europepmc   +1 more source

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent. [PDF]

Front Pharmacol
Wang R, Jin Y, Zou B, Ding L.
europepmc   +1 more source