Results 151 to 160 of about 63,034 (211)

Physiologically-Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib. [PDF]

CPT Pharmacometrics Syst Pharmacol
Lewis GJ, Jewell RC, Krishnatry AS, Taskar KS.   +3 more
europepmc   +1 more source

The Absorption, Distribution, Excretion, and In Vitro Hepatic Microsomal Metabolism of the Novel CDK Compound XMD12 in Sprague-Dawley Rats. [PDF]

Pharmaceutics
Zheng XH, Chang YC, Li YH, He YX, Zhao PX, Wang FF, Xu JY, Tan YF.   +7 more
europepmc   +1 more source

Use of a cytochrome P450 humanised mouse model to refine schistosomiasis drug discovery

Davey SD, Forde-Thomas JE, Hulme BJ, Lees K, Costain AH, Evans M, Rinaldi G, Frame L, Stojanovski L, Simeons FRC, Tavendale A, Kenneth MacLeod A, Pichon R, Lee Y, Polak O, Chalmers IW, Dankwa B, Odhiambo BK, Guimaraes VH, Hegarty M, Swain MT, Aubrey W, Caldwell N, MacDonald AS, Gilbert IH, Baragaña B, Read KD, Hoffmann KF.   +27 more
europepmc   +1 more source

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Microsomal antigens in developing chick liver

Experimental Cell Research, 1965
Abstract Microsomes from embryonic and adult chick liver have been analyzed by homologous antisera. The deoxycholate-soluble fraction of embryonic microsomes contains a group of antigens typical to this fraction, but present only as a trace in the adult-homologous fraction.
V, MUTOLO, V, D AMELIO, E, PIAZZA
openaire   +2 more sources

Hydroperoxide peroxidase activity in liver microsomes

Life Sciences, 1974
Abstract The oxidation of either NADH or NADPH by cumene hydroperoxide in rat liver microsomes is described. The Km′ for the hydroperoxide varied with the pyridine nucleotide utilized (NADPH, Km′ = 0.91 mM; NADH, Km′ = 3.3 mM). Carbon monoxide did not inhibit the peroxidase activity although a variety of other agents which interact with cytochrome ...
W R, Bidlack, P, Hochstein
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A microsomal endoribonuclease from rat liver

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1980
An endoribonuclease has been purified about 320-fold from the microsomes of rat liver. The enzyme had an apparent molecular weight of 54 000-58 000 and produced oligonucleotides, each consisting of 3-7 nucleotides from poly(A) and poly(U). No mononucleotide was obtained by the enzymatic hydrolysis of poly(A) and poly(U) under standard coditions.
H, Kumagai, K, Igarashi, T, Takayama, K, Watanabe, K, Sugimoto, S, Hirose   +5 more
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Ethylene Formation in Rat Liver Microsomes

Science, 1966
Reduced triphosphopyridine nucleotide and pyrophosphate-dependent peroxidation of lipids in rat liver microsomes were coupled to the generation of ethylene in the presence of cuprous ions. This system suggests a model for the biogenesis of ethylene in cells.
M, Lieberman, P, Hochstein
openaire   +2 more sources

Chromate metabolism in liver microsomes

Biological Trace Element Research, 1979
The carcinogenicity and mutagenicity of various chromium compounds have been found to be markedly dependent on the oxidation state of the metal. The carcinogen chromate was reduced to chromium(III) by rat liver microsomes in vitro. Metabolism of chromate by microsomal enzymes occurred only in the presence of either NADPH or NADH as cofactor.
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Pigments of rat liver microsomes

Archives of Biochemistry and Biophysics, 1958
Abstract The total hemin content of washed rat liver microsomes is 2.15 times the cytochrome b5 content, only a small part being due to bound hemoglobin. The content of flavine is 4 5 that of cytochrome b5. The flavine probably does not contribute to the DPNH reduced difference spectrum.
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Kavalactone Metabolism in Rat Liver Microsomes

Phytotherapy Research, 2011
The specific CYP enzymes involved in kavalactone (KLT) metabolism and their kinetics have not been fully examined. This study used rat liver microsomes (RLM) to determine kavain (KA), methysticin (MTS) and desmethoxyyangonin (DMY) enzyme kinetic parameters, to elucidate the major CYP450 isoforms involved in KLT metabolism and to examine gender ...
Shuang, Fu, Anthony, Rowe, Iqbal, Ramzan
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