Results 151 to 160 of about 34,918 (236)

Discovery of 5‑Azaindole Inhibitors of O‑GlcNAcase for the Treatment of Alzheimer's Disease and Related Tauopathies. [PDF]

ACS Med Chem Lett
Bouton J, Bretteville A, Tresadern G, Shaffer P, Austin N, Buijnsters P, Cedervall EP, Darville N, Fonteyn I, Leenaerts J, Lamenca CM, Mertens L, Peeters D, Velter AI, Roosbroeck YV, Ebneth A, Bartolomé JM, Trabanco AA, Oehlrich D.   +18 more
europepmc   +1 more source

Comprehensive Review on the Toxicity of Five Main AQ Constituents from Rhubarb: Mechanisms, Challenges and Future Perspectives. [PDF]

Drug Des Devel Ther
Yu L, Jiang Y, Li P, Wang J, Tang P, Zhao Y.   +5 more
europepmc   +1 more source

Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids. [PDF]

Proc Natl Acad Sci U S A
Tripathy SK, Mahapatra A, Saharan O, Chatterjee H, Sengupta N, Kamat S, Nair S, Mallik R.   +7 more
europepmc   +1 more source

Discovery of <i>N</i>-Acetyltransferase 8-Like (NAT8L) inhibitors based on a <i>N</i>-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold. [PDF]

ACS Med Chem Lett
Nayeen MJ, Thomas AG, Kundu B, Carlyle E, Hin N, Hin P, Pal A, Paule J, Rais R, Slusher BS, Tsukamoto T.   +10 more
europepmc   +1 more source

Early ADME and Preliminary Toxicity Studies of I-152, an <i>N</i>-Acetyl-l-Cysteine/<i>S</i>-Acetylcysteamine Conjugate. [PDF]

Chem Res Toxicol
Bartoccini F, Valeri A, Gregori M, Masini S, Bruschi M, Goracci L, Fraternale A, Piersanti G.   +7 more
europepmc   +1 more source

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively. [PDF]

Pharmaceuticals (Basel)
Grangeon A, Arwood ML, Thacker D, Gaudette F, Turgeon J, Michaud V.   +5 more
europepmc   +1 more source

Development of highly potent EP2 antagonists as novel anti-inflammatory neuroprotectants. [PDF]

Bioorg Med Chem
Jiang C, Cho EB, Jin Z, Bahraminejad S, Ma D, Yu Y, Liu J, Jiang J.   +7 more
europepmc   +1 more source

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent. [PDF]

Front Pharmacol
Wang R, Jin Y, Zou B, Ding L.
europepmc   +1 more source

Metabolism of the Isoflavone Derivative Structural Isomers ACF-02 and ACF-03 in Human Liver Microsomes. [PDF]

Pharmaceutics
Liang Z, Kim EH, Kim GY, Choi JH, Seo HJ, Liu KH, Cho M.   +6 more
europepmc   +1 more source

The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB-85387 Is Associated With Weight Loss in Mice With Obesity. [PDF]

Obes Sci Pract
Corbalan JJ, Jagadeesan P, Huang CY, Beasley JR, Nickels JT.   +4 more
europepmc   +1 more source