Results 131 to 140 of about 2,738,308 (324)

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

open access: yesPhytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko   +3 more
wiley   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

open access: yesPhytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit   +5 more
wiley   +1 more source

Scheme for metabolites of 1a observed with human liver microsomes.

open access: yes, 2018
Scheme for metabolites of 1a observed with human liver microsomes.
Alfin D. N. Vaz (172262)   +8 more
core   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

open access: yesSmart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin   +10 more
wiley   +1 more source

H6PDH activity in rat liver, testis and liver parenchymal cell and Leydig cell microsomes.

open access: yes, 2015
Similar letters showed no significant differences between groups.H6PDH activity in rat liver, testis and liver parenchymal cell and Leydig cell microsomes.
Yuan-Yuan Hu (821108)   +10 more
core   +1 more source

Effect of Propylparaben on In Vitro Maturation of Porcine Oocytes and Embryo Development

open access: yesEnvironmental Toxicology, EarlyView.
ABSTRACT Parabens are synthetic chemicals that, due to their antibacterial and fungicidal effects, are widely used as preservatives in food, cosmetics, and personal care products, such as shampoos, hair conditioners, body creams, soaps, deodorants, makeup, wet wipes, lotions, female hygiene products, and vaginal lubricants. Several years ago, they were
Elivier Núñez‐Macías   +10 more
wiley   +1 more source

Gonadal Development–Related Genes and a Male‐Specific Genetic Marker Identified in the Endangered Sichuan Taimen (Hucho bleekeri)

open access: yesIntegrative Zoology, EarlyView.
Integrated transcriptomic and proteomic analyses were used to validate gonadal development–related genes and to identify a sex‐specific molecular marker in Hucho bleekeri. ABSTRACT Sex determination and differentiation represent fundamental topics in reproductive biology. Sichuan taimen (Hucho bleekeri), a first‐class national protected fish species in
Qinyao Wei   +5 more
wiley   +1 more source

A PRELIMINARY EUROPEAN LIVER AND INTESTINE TRANSPLANT ASSOCIATION -EUROPEAN LIVER TRANSPLANT REGISTRY STUDY ON INFORMED RECIPIENT CONSENT AND EXTENDED CRITERIA LIVER DONATION

open access: yes, 2013
The European Liver and Intestine Transplant Association (ELITA) and the European Liver Transplant Registry (ELTR) coordinated the distribution to European liver transplantation centers of an electronic questionnaire, developed by the first author ...
D. Giannarelli   +5 more
core   +1 more source

The Bidirectional Association Between MASLD and Male Hypogonadism: An Updated Meta‐Analysis

open access: yesAndrology, EarlyView.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) and male hypogonadism are increasingly prevalent, metabolically interrelated conditions. Testosterone (T) deficiency has been implicated in hepatic lipid dysregulation, insulin resistance, and visceral adiposity, whereas MASLD may impair the hypothalamic–pituitary ...
Giorgia Spaggiari   +9 more
wiley   +1 more source

Theophylline Metabolism by Human, Rabbit and Rat Liver Microsomes and by Purified Forms of Cytochrome P450

open access: yes, 1988
The capacity of human, rabbit and rat liver microsomes and purified isozymes of cytochrome P450 to metabolize theophylline has been assessed. In all three species the 8-hydroxylation of theophylline to 1,3-dimethyluric acid (1,3-DMU) was the major ...
J O Miners   +4 more
core   +1 more source

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