Results 131 to 140 of about 28,121 (229)

Interaction of Cytochrome P450 3A4 with Fatty Acid Binding Protein 1 and Relevance to Drug Metabolism. [PDF]

J Med Chem
McCarty KD, Proffett DLD, Guengerich FP.
europepmc   +1 more source

<i>In Vitro</i> Liver Models for Studying Pharmaceutical Metabolism in Fish - A Critical Analysis of Their Applications and Limitations. [PDF]

Environ Sci Technol
Matthee C, Pihlaja TLM, Järvinen P, Brown AR, Lange A, Sikanen TM, Tyler CR.   +6 more
europepmc   +1 more source

Effects of Newer Veterinary Macrolide Antimicrobials on the CYP3A-Dependent Metabolism in Cattle Liver Microsomes: Potential Metabolic Drug-Drug Interaction with Monensin. [PDF]

Animals (Basel)
Ichinose P, Munafó JP, Miró MV, Valente M, Moreno-Torrejón L, Larsen K, Lanusse C, Lifschitz A, Virkel G.   +8 more
europepmc   +1 more source

Comprehensive Pharmacokinetics of the Marine-Derived PDE4 Inhibitor LY104 and Its Major Metabolite M1 in Rats: A Validated LC-MS/MS Method with Sex Comparison, Multiple-Dose, Protein Binding, Metabolic Stability, and Excretion Studies. [PDF]

Mar Drugs
Niu X, Zhao J, Ding D, He W, Du G, Hao J, Zhao J.   +6 more
europepmc   +1 more source

Reductive dominance and limited cytochrome P450 activity in neonicotinoid metabolism by elephant liver microsomes. [PDF]

J Vet Med Sci
Watanabe K, Khidkhan K, Saengtienchai A, Somgrid C, Towiboon P, Angkawanish T, Langkaphin W, Namwongprom K, Kittisirik N, Yohannes YB, Ikenaka Y, Nakayama SM, Ishizuka M.   +12 more
europepmc   +1 more source

Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism. [PDF]

Sci Rep
Kinatukara N, Xu X, Shah P.
europepmc   +1 more source

The novel third-generation antipsychotic drug brexpiprazole affects hepatic transcription factors, serum hormone levels, and cytochrome P450 enzymes after prolonged treatment: pharmacological significance. [PDF]

Pharmacol Rep
Danek PJ, Pukło R, Daniel WA.
europepmc   +1 more source

Pharmacokinetics, distribution, metabolism, excretion and safety characterization of ZJCK-6-72: novel DYRK1A inhibitor with optimized brain exposure for Alzheimer's disease therapy. [PDF]

Front Pharmacol
Li Z, Chen H, Li X, Yang A, Wang X, Liu S, Ning X, Zhou L, Zheng F, Xun F, Hu B, Cui Y, Yao D, Gao X, Xu Z, Zhao Q.   +15 more
europepmc   +1 more source

Unraveling Cannabidiol's Bidirectional Regulation of Melatonin Pharmacokinetics via PEPT1/CYP1A2: Mechanistic Insights and Quantitative Projections. [PDF]

Pharmaceuticals (Basel)
Zheng B, Wang M, Zhang Q, Li C, Wang L, Zhang W, Liu C, Zhuang X.   +7 more
europepmc   +1 more source

The effect of salidroside, an active component of Rhodiola rosea, on the metabolic activity of rat and human cytochromes P450 in preclinical studies. [PDF]

Pharmacol Rep
Klaskova E, Jurica J, Danek PJ, Mlcuchova N, Eyrilmez SM, Borilova Linhartova P, Bednar D, Kamaraj R, Daniel WA, Zendulka O.   +9 more
europepmc   +1 more source