Results 121 to 130 of about 28,121 (229)

Metal–Drug Complexes as Long‐Release Application for Antimalarial PfFNT‐Inhibitors

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
P. falciparum formate‐nitrite transporter (PfFNT) inhibitors have emerged as a novel antimalarial class with potent in vivo and liver‐stage activity. Low‐solubility metal–inhibitor complexes were prepared as potential long‐acting injectables.
Finn Tiedjens, Björn Henke, Ulrich Girreser, Regina Scherließ, Eric Beitz   +4 more
wiley   +1 more source

Characterization of Atrasentan Metabolic Pathway in Human Liver Microsomes Using Feature-Based Molecular Networking. [PDF]

Pharmaceutics
Seo HJ, Liang Z, Kim EH, Liu KH.
europepmc   +1 more source

Hit‐To‐Lead Optimization of a Pyridylpiperazine Class Against Malaria: Pharmacokinetic Profile and In Vivo Efficacy of Optimized Compounds

ChemMedChem, Volume 21, Issue 13, 14 July 2026.
Chemical optimization of a novel pyridylpiperazine class yields two promising antimalarial candidates with an exceptional balance of metabolic stability and solubility. These optimized leads significantly protect mice from cerebral malaria, reducing parasitic load by up to 91.7%.
Douglas Davison da Silva Oliveira, Duarte Eduardo Pereira, Rafael Consolin Chelucci, Simone Michelan, Júlia Maria Fernandes Pituba, Adriano D. Andricopulo, Leonardo L. G. Ferreira, Neide Maria Silva, Celso de Oliveira Rezende Júnior   +8 more
wiley   +1 more source

Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications. [PDF]

Sci Rep
Lee MS, Song IS, Jang Y, Cho YY, Lee JY, Kang HC, Kim JH, Lee HS.   +7 more
europepmc   +1 more source

<i>In Vitro</i> characterization of narciclasine: solubility, metabolic stability, and P-glycoprotein substrate status. [PDF]

Front Pharmacol
Akkireddy R, Yang IH, Lenkalapelly S, Kshirsagar GJ, May HA, Kang MH.   +5 more
europepmc   +1 more source

Toxicokinetic-Oriented Assessment of Nepetalactone Using In Silico ADMET Modeling, In Vitro Rat and Human Liver Microsomes, and UHPLC-MS/MS Metabolite Characterization. [PDF]

Toxics
Stoica NB, Cascajosa-Lira A, Morea A, Catunescu GM, Hornedo-Ortega R, Guzmán-Guillén R.   +5 more
europepmc   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Overlooked aspects of scaling enzyme activity through abundance across tissues and individuals: Insights from k_cat measurements in matched liver and intestinal samples. [PDF]

Drug Metab Dispos
Al-Majdoub ZM, Barber J, Rostami-Hodjegan A, Galetin A, Scotcher D.   +4 more
europepmc   +1 more source

Berberine and Metabolic Dysfunction‐Associated Steatotic Liver Disease: Hope or Hype?

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
Ruth Nona, Eric Kalo
wiley   +1 more source

Dietary allicin supplementation inhibits hepatic CYP3A37 in chickens: Evidence from in vitro and in vivo models. [PDF]

Poult Sci
Li Y, Yuan H, Wang J, Yin S, Qiu X, Yang H.   +5 more
europepmc   +1 more source