Results 101 to 110 of about 34,918 (236)
ABSTRACT This case describes a child with T‐cell acute lymphoblastic leukemia (T‐ALL) presenting atypically with ascites and bilateral pedal edema, initially suggesting autoimmune hepatitis. The diagnosis was established only after flow cytometry of ascitic fluid.
Kainat Shaikh +5 more
wiley +1 more source
ABSTRACT Cholestasis beyond infancy is uncommon and presents a diagnostic challenge. We report an 11‐year‐old girl presenting with severe pruritus followed by jaundice and a cholestatic biochemical profile with normal gamma‐glutamyl transferase levels. Extensive evaluation excluded infectious, autoimmune, metabolic, and obstructive causes. Liver biopsy
Ahmad Hosiian +6 more
wiley +1 more source
Objective: To study the metabolism of medroxyprogesterone acetate (MPA) in human liver microsomes and compare the metabolim profile with rat, minipig liver mcirosomes and recombinant human CYP3A4.
张江伟, 李巍, 刘勇, 杨凌
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Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia
Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub +5 more
wiley +1 more source
Bioactive fatty acids from agro‐industrial byproducts are highlighted as a promising avenue for managing diabetes in this review, which aims to develop targeted interventions for optimal utilization and therapeutic benefits. ABSTRACT Diabetes mellitus (DM), influenced by multifaceted factors, creates a complex imbalance within the body. Nutrition plays
Youssef Elouafy +7 more
wiley +1 more source
Achillea millefolium Linn., commonly known as yarrow, is an extraordinary medicinal plant. A. millefolium has broad therapeutic potential due to its phytochemistry and essential oil composition. It possesses pharmacological properties, including antidiabetic, antioxidant, anti‐inflammatory, liver‐protective, antimicrobial, and gastroprotective effects,
Tooba Majeed +14 more
wiley +1 more source
Reproxalap ‐ A Novel Treatment Option for Allergic Conjunctivitis – A Comprehensive Narrative Review
ABSTRACT Background and Aims Allergic conjunctivitis is a prevalent, immune‐mediated hypersensitivity disorder of the ocular surface affecting 10%–20% of the global population. Current therapeutic options, while effective to some extent, are often limited by side effects and inconsistent efficacy.
Sanila Mughal +7 more
wiley +1 more source
Cross-species metabolic characterization of eutylone and mechanism-based inhibition of CYP2D6 and CYP2B6 with drug interaction implications. [PDF]
Lee MS +7 more
europepmc +1 more source
Epoxidation of aldrin by rainbow trout liver microsomes
Assay conditions and analytical methods established for the study of epoxidation of the insecticides aldrin and heptachlor, by rat liver microsomes have been employed to study the same reaction catalyzed by trout liver microsomes.
Chan, Timothy Ming-wai
core
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Morio Yamada +3 more
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