Results 111 to 120 of about 63,034 (211)

Discovery of <i>N</i>-Acetyltransferase 8-Like (NAT8L) inhibitors based on a <i>N</i>-Acylated (Piperidin-3-ylmethyl)-1,2,4-Oxadiazole Scaffold. [PDF]

ACS Med Chem Lett
Nayeen MJ, Thomas AG, Kundu B, Carlyle E, Hin N, Hin P, Pal A, Paule J, Rais R, Slusher BS, Tsukamoto T.   +10 more
europepmc   +1 more source

Protein Levels of 16 Cytochrome P450s and 2 Carboxyl Esterases Using Absolute Quantitative Proteomics: CYP2C9 and CYP3A4 Are the Most Abundant Isoforms in Human Liver and Intestine, Respectively. [PDF]

Pharmaceuticals (Basel)
Grangeon A, Arwood ML, Thacker D, Gaudette F, Turgeon J, Michaud V.   +5 more
europepmc   +1 more source

Preclinical pharmacokinetic characterization of (R)-ketamine injection, a novel antidepressant glutamatergic agent. [PDF]

Front Pharmacol
Wang R, Jin Y, Zou B, Ding L.
europepmc   +1 more source

Metabolism of the Isoflavone Derivative Structural Isomers ACF-02 and ACF-03 in Human Liver Microsomes. [PDF]

Pharmaceutics
Liang Z, Kim EH, Kim GY, Choi JH, Seo HJ, Liu KH, Cho M.   +6 more
europepmc   +1 more source

The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB-85387 Is Associated With Weight Loss in Mice With Obesity. [PDF]

Obes Sci Pract
Corbalan JJ, Jagadeesan P, Huang CY, Beasley JR, Nickels JT.   +4 more
europepmc   +1 more source

Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs. [PDF]

Drug Metab Dispos
Shimizu M, Nii A, Uno Y, Yamazaki H.
europepmc   +1 more source

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats. [PDF]

Drug Des Devel Ther
Xie C, Guan T, Huang J, Chen J, Li Y, Zheng P.   +5 more
europepmc   +1 more source

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics. [PDF]

ACS Pharmacol Transl Sci
Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T, Faibille AB, Bourn LA, Ramdhan PA, Ricchezza J, Jordan S, Panasis D, Nguyen N, Kasarla N, Wang B, Garcia SS, Saez J, Paule J, Lee CB, Rais R, Slusher BS, Sibley DR, Li C, Keck TM, Boateng CA.   +24 more
europepmc   +1 more source

Influence of the lysosomal elastase inhibitor eglin on development of interstitial lung edema in E. coli bacteremia in pigs [PDF]

, 1987
Jochum, Marianne, Redl, H., Schlag, G., Siebeck, Matthias, Thetter, O., Welter, H. F.   +5 more
core  

The Effect of <i>N</i>-Alkyl Azole Difluorination on Molecular Properties Relevant for Compound Optimization: A Comparative Study. [PDF]

ACS Med Chem Lett
Herrick RM, Green SA, Rich S, Grandner JM, Huard K, Altman RA.   +5 more
europepmc   +1 more source