Results 111 to 120 of about 2,738,308 (324)
Characterization of in vitro bioactivation of rutaecarpine in human liver microsomes (HLMs)
, 2010 Reactive drug metabolites have been always considered mediators of drug-induced toxicities and risk would increase with the increasing reactive metabolites.
房中则, Ling Yang, 杨凌
core
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine ChanSu with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core
Journal of Applied Toxicology, EarlyView.ABSTRACT The extensive use of pesticides in modern agriculture has raised increasing concerns regarding the potential biological effects of repeated exposure to pesticide residues and commercial formulations. Mancozeb is a widely used ethylene‐bis‐dithiocarbamate fungicide; however, information on its hematological and genotoxic effects following ...
Matheus Henrique Barcelos Figueiredo +10 more
wiley +1 more source
Inhibition of rat microsomal lipid peroxidation by the oral administration of D002
Brazilian Journal of Medical and Biological Research, 2000 The effect of D002, a defined mixture of higher primary alcohols purified from bee wax, on in vivo and in vitro lipid peroxidation was studied. The extent of lipid peroxidation was measured on the basis of the levels of thiobarbituric acid reactive ...
Menéndez R. +4 more
doaj
Journal of Lipid Research, 1986 The stereospecificity of monoacylglycerol acyltransferase from rat intestinal mucosa and suckling rat liver microsomes was examined using sn-1,2-diacylglycerol kinase from Escherichia coli.
R A Coleman +3 more
doaj +1 more source
Comparative Metabolism of Cinobuafgin in Liver Microsomes from Mouse,Rat,Dog,Pig,Monkey and Human
, 2010 Cinobufagin (CBG), a major bioactive component of Traditional Chinese Medicine Chan-Su with digoxin-like structure, has been reported with Na+-K+-ATPase inhibitory effects and outstanding antitumor activities.
梁思成 +4 more
core
Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes
, 1987 1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. Covalent binding of [14C] 1,1-DCE to isolated lung and liver microsomes from CD-1 mice required NADPH and was strongly inhibited by carbon monoxide.
P. G. Forkert, W. J. Racz, M. Hofley
core +1 more source
A hepatic enigma: Pediatric presentation of primary biliary cholangitis
JPGN Reports, EarlyView.Abstract Primary biliary cholangitis (PBC) is a chronic autoimmune condition characterized by destruction of intrahepatic bile ducts, leading to fibrosis and cirrhosis of the liver. It is an extremely rare pediatric disease with very few pediatric cases reported to date. Here, we report the case of a 14‐year‐old female who presented with elevated liver
Sindhura Kasturi +3 more
wiley +1 more source
Characterization Of In Vitro Metabolism of Brucine Using Human Liver Microsomes
, 2010 Background. Brucine, one of the bitter alkaloids isolated from Chinese folk medicine Strychnos nux-vomica L. (Loganiaceae), is known as an effective analgesic and anti- inflammatory agent for relieving arthritic and traumatic pain.
房中则 +4 more
core
Anticancer potential of berberine: Molecular pathways and current clinical trial perspectives
JSFA reports, EarlyView.Abstract Cancer is constantly rising mortality rates due to its late prognosis, poor management, and expensive treatment. Multi‐sectoral approaches for cancer management include hygienic practices, synthetic drug exploitation, radiation therapy, and diet modifications.
Muhammad Maaz +10 more
wiley +1 more source