Results 161 to 170 of about 28,121 (229)

Development of highly potent EP2 antagonists as novel anti-inflammatory neuroprotectants. [PDF]

Bioorg Med Chem
Jiang C, Cho EB, Jin Z, Bahraminejad S, Ma D, Yu Y, Liu J, Jiang J.   +7 more
europepmc   +1 more source

Metabolism of the Isoflavone Derivative Structural Isomers ACF-02 and ACF-03 in Human Liver Microsomes. [PDF]

Pharmaceutics
Liang Z, Kim EH, Kim GY, Choi JH, Seo HJ, Liu KH, Cho M.   +6 more
europepmc   +1 more source

Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs. [PDF]

Drug Metab Dispos
Shimizu M, Nii A, Uno Y, Yamazaki H.
europepmc   +1 more source

The Human Monoacylglycerol Acyltransferase 2 Inhibitor VB-85387 Is Associated With Weight Loss in Mice With Obesity. [PDF]

Obes Sci Pract
Corbalan JJ, Jagadeesan P, Huang CY, Beasley JR, Nickels JT.   +4 more
europepmc   +1 more source

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats. [PDF]

Drug Des Devel Ther
Xie C, Guan T, Huang J, Chen J, Li Y, Zheng P.   +5 more
europepmc   +1 more source

UGT2B15 Acts as a Critical Detoxification Barrier Against Chemi-Cal-Induced Hepatotoxicity and Carcinogenesis via the Androgen Receptor Axis. [PDF]

Cells
Zhao Y, Wang Y, Li Y, Liu S, Jia Z, Wang Y, Zhang R, Liu Z, Lu L.   +8 more
europepmc   +1 more source

Characterization of trazodone metabolic pathways and species-specific profiles. [PDF]

Front Pharmacol
Petrucci V, Dragone P, Laurenti MC, Oggianu L, Zabela V, Cattaneo A.   +5 more
europepmc   +1 more source

Comments to the Article Wu Y, Völler S, Goulooze SC, et al. A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. J Clin Pharmacol. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303. [PDF]

J Clin Pharmacol
Pasanen M, Juvonen RO.
europepmc   +1 more source

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics. [PDF]

ACS Pharmacol Transl Sci
Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T, Faibille AB, Bourn LA, Ramdhan PA, Ricchezza J, Jordan S, Panasis D, Nguyen N, Kasarla N, Wang B, Garcia SS, Saez J, Paule J, Lee CB, Rais R, Slusher BS, Sibley DR, Li C, Keck TM, Boateng CA.   +24 more
europepmc   +1 more source