Results 161 to 170 of about 34,918 (236)

UGT2B15 Acts as a Critical Detoxification Barrier Against Chemi-Cal-Induced Hepatotoxicity and Carcinogenesis via the Androgen Receptor Axis. [PDF]

Cells
Zhao Y, Wang Y, Li Y, Liu S, Jia Z, Wang Y, Zhang R, Liu Z, Lu L.   +8 more
europepmc   +1 more source

Triethylamine N-oxygenation mediated by liver and kidney microsomes and recombinant flavin-containing monooxygenase 3 (FMO3) and FMO1 proteins from humans, monkeys, pigs, and dogs. [PDF]

Drug Metab Dispos
Shimizu M, Nii A, Uno Y, Yamazaki H.
europepmc   +1 more source

Comments to the Article Wu Y, Völler S, Goulooze SC, et al. A Novel Maturation Equation for Hepatic Clearance Across Preterm, Term Neonates, Children, and Adults: Application to Paracetamol and Its Metabolite. J Clin Pharmacol. 2025;65(12):1829-1843. doi: 10.1002/jcph.70080. PMID: 40910464; PMCID: PMC12649303. [PDF]

J Clin Pharmacol
Pasanen M, Juvonen RO.
europepmc   +1 more source

Cyp3a4-Mediated in vitro Metabolism and in vivo Disposition of Lorlatinib in Rats. [PDF]

Drug Des Devel Ther
Xie C, Guan T, Huang J, Chen J, Li Y, Zheng P.   +5 more
europepmc   +1 more source

N- and O‑Prenylated Quinolones: Syntheses and <i>In Vitro</i> and <i>In Vivo</i> Antischistosomal Evaluation. [PDF]

ACS Med Chem Lett
Khethang K, Häberli C, Dube PS, Legoabe LJ, Keiser J, Beteck RM.   +5 more
europepmc   +1 more source

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics. [PDF]

ACS Pharmacol Transl Sci
Alkhatib M, Jakobs FM, Hanson JN, Nilson AN, Moritz AE, Li T, Faibille AB, Bourn LA, Ramdhan PA, Ricchezza J, Jordan S, Panasis D, Nguyen N, Kasarla N, Wang B, Garcia SS, Saez J, Paule J, Lee CB, Rais R, Slusher BS, Sibley DR, Li C, Keck TM, Boateng CA.   +24 more
europepmc   +1 more source

Characterization of trazodone metabolic pathways and species-specific profiles. [PDF]

Front Pharmacol
Petrucci V, Dragone P, Laurenti MC, Oggianu L, Zabela V, Cattaneo A.   +5 more
europepmc   +1 more source

The Effect of <i>N</i>-Alkyl Azole Difluorination on Molecular Properties Relevant for Compound Optimization: A Comparative Study. [PDF]

ACS Med Chem Lett
Herrick RM, Green SA, Rich S, Grandner JM, Huard K, Altman RA.   +5 more
europepmc   +1 more source

In Vitro and Clinical Evaluation of Potential Interactions of Bemnifosbuvir with Drug-Metabolizing Enzymes. [PDF]

J Clin Pharmacol
Zhou XJ, Vo A, Morelli G, Montrond M, Lynch S, Pietropaolo K, Belanger B, Good S, Horga A, Agrawal N, Hammond J.   +10 more
europepmc   +1 more source