Results 251 to 260 of about 2,738,308 (324)

Metabolism of naphthalene by pigeon liver microsomes

Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 1979
Abstract 1. Microsomal mixed-function oxidase of the pigeon liver shows maximum activity and stability at 44°C and 6.8 pH. Naphthalene is metabolized to 1-naphthol and 1,2-diol and a number of minor metabolites. The MFO activity and P-450 contents of pigeon liver microsomes, under optimum conditions show about 1 3 to 1 4 activity of ...
J C, Grossman, M A, Khan
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Development of Liver Microsomal Oxidations in the Chick

Xenobiotica, 1976
1. Liver microsomal preparations from chick embryos (1 day before hatching) and from 1-7 day old chicks were assayed for oxidative drug-metabolizing activity with aminopyrine, aniline and naphthalene as substrates. 2. Activities for all three substrates were highest in preparations from 1 day-old chicks.
G, Powis, A H, Drummond, D E, Macintyre, W R, Jondorf   +3 more
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Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms.

Journal of Pharmacology and Experimental Therapeutics, 2001
Interindividual variability in acetaminophen (APAP) glucuronidation may contribute to differences in susceptibility to APAP intoxication in humans.
M. Court, Su X. Duan, L. V. von Moltke, D. Greenblatt, C. Patten, J. Miners, P. Mackenzie   +6 more
semanticscholar   +1 more source

Activation of slaframine by liver microsomes and flavins

Biochemical Pharmacology, 1971
Abstract Liver homogenates, in the presence of NADPH, are capable of activating slaframine to a form capable of stimulation in vitro of the guinea pig ileum. Activation activity has been located in the microsomal fraction and required NADPH; however, the reaction was not inhibited by carbon monoxide.
T E, Spike, S D, Aust
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Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

Drug Metabolism And Disposition, 1999
The purpose of this study was to compare the kinetics of intestinal and hepatic cytochrome P-450 3A (CYP3A) inhibition by using microsomal midazolam 1'-hydroxylation as a marker of enzyme activity.
M. Gibbs, K. Thummel, D. Shen, K. Kunze
semanticscholar   +1 more source

Microsomal Esterification of Retinol in Human Liver

Acta Medica Scandinavica, 1984
Abstract Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes.
M, Rasmussen, P, Helgerud, L B, Petersen, K R, Norum   +3 more
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A microsomal exoribonuclease from rat liver

Biochimica et Biophysica Acta (BBA) - Enzymology, 1979
A exoribonuclease has been purified from the microsomes of rat liver. The enzyme had an apparent molecular weight of 80 000-83 000 and produced, via a processive mechanism, 5'-AMP as the only product from poly(A). The degradation was found to proceed in the 3' to 5' direction.
H, Kumagai, K, Igarashi, K, Tanaka, H, Nakao, S, Hirose   +4 more
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The interaction of cimetidine with rat liver microsomes

Biochemical Pharmacology, 1983
The binding of cimetidine to rat liver microsomes in M/15 phosphate buffer, pH 7.9, has been investigated by difference spectroscopy and also by equilibrium partition studies, the latter method providing the more definitive characterization of the interaction in the pharmacologically relevant, low micromolar range of drug concn. In addition, the effect
Reilly P.E.B., Carrington L.E., Winzor D.J.   +2 more
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Esterification of cholesterol in rat liver microsomes

Archives of Biochemistry and Biophysics, 1964
Washed rat liver microsomes esterify cholesterol in the presence of added ATP and CoA; net synthesis of cholesterol esters was demonstrated. The optimum pH of the reaction was between 6.8 and 7.2; the effects of time and concentration of substrate were investigated.
L, SWELL, M D, LAW, C R, TREADWELL
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Metabolism of doxophylline by rat liver microsomes.

Drug Metabolism and Disposition, 1986
The metabolic transformation of the bronchospasmolytic agent doxophylline (2-(7'-theophyllinemethyl)-1,3-dioxolane) was studied in vitro with phenobarbital-induced rat liver microsomal fraction containing the NADPH-generating system. Doxophylline was poorly metabolized as 95% of the recovered material was parent compound. The major metabolite resulted:
GROSA, Giorgio, J. S. FRANZONE, G. BIGLINO   +2 more
openaire   +3 more sources