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Horizontal Transmission of the Symbiont Microsporidia MB in Anopheles arabiensis [PDF]

Frontiers in Microbiology, 2021
The recently discovered Anopheles symbiont, Microsporidia MB, has a strong malaria transmission-blocking phenotype in Anopheles arabiensis, the predominant Anopheles gambiae species complex member in many active transmission areas in eastern Africa.
Godfrey Nattoh, Godfrey Nattoh, Tracy Maina, Edward E. Makhulu, Lilian Mbaisi, Enock Mararo, Fidel G. Otieno, Tullu Bukhari, Thomas O. Onchuru, Thomas O. Onchuru, Evan Teal, Juan Paredes, Joel L. Bargul, Joel L. Bargul, David M. Mburu, Everline A. Onyango, Gabriel Magoma, Gabriel Magoma, Steven P. Sinkins, Jeremy K. Herren   +19 more
doaj   +13 more sources

Investigation of prevalence and phylogenetic classification of Microsporidia MB and insecticide target site insensitivity resistance mutations in Anopheles gambiae s.l. and Anopheles funestus mosquitoes from Busia, Kenya [PDF]

BMC Microbiology
Background Microsporidia MB, a Plasmodium-transmission-impairing symbiont in Anopheles arabiensis, has malaria control potential. This study assessed its prevalence and phylogeny in An. gambiae s.l. and An.
Herzel Tiffany Wandera, Godfrey Nattoh, Daniel Kiboi, Manase Onyango Aloo, Stanley Kitur, Sharon Nyagaka, Malvin Atieno Otieno, Eric Ochomo, Damaris Matoke-Muhia, Jeremy Keith Herren, Luna Kamau   +10 more
doaj   +7 more sources

Microsporidia MB is found predominantly associated with Anopheles gambiae s.s and Anopheles coluzzii in Ghana [PDF]

Scientific Reports, 2021
A vertically transmitted microsporidian, Microsporidia MB, with the ability to disrupt Plasmodium development was reported in Anopheles arabiensis from Kenya, East Africa.
Jewelna Akorli, Esinam Abla Akorli, Seraphim Naa Afoley Tetteh, Godwin Kwame Amlalo, Millicent Opoku, Rebecca Pwalia, Michelle Adimazoya, Dorcas Atibilla, Sellase Pi-Bansa, Joseph Chabi, Samuel Kweku Dadzie   +10 more
doaj   +8 more sources

Microsporidia MB in the primary malaria vector Anopheles gambiae sensu stricto is avirulent and undergoes maternal and horizontal transmission [PDF]

Parasites & Vectors, 2023
Background The demonstration that the recently discovered Anopheles symbiont Microsporidia MB blocks malaria transmission in Anopheles arabiensis and undergoes vertical and horizontal transmission suggests that it is a promising candidate for the ...
Godfrey Nattoh, Brenda Onyango, Edward Edmond Makhulu, Diana Omoke, Lilian Mbaisi Ang’ang’o, Luna Kamau, Maxwell Machani Gesuge, Eric Ochomo, Jeremy Keith Herren   +8 more
doaj   +5 more sources

Monitoring the Capacity of Microsporidia MB Transgenerational Spread in Anopheles arabiensis Populations [PDF]

Insects
Microsporidia MB is a natural symbiont of Anopheles arabiensis Patton, 1905 that blocks Plasmodium transmission without compromising mosquito fitness.
Godfred Yaw Boanyah, Lizette L. Koekemoer, Jeremy K. Herren, Tullu Bukhari   +3 more
doaj   +4 more sources

The dissemination potential of Microsporidia MB in Anopheles arabiensis mosquitoes is modulated by temperature [PDF]

Scientific Reports
Microsporidia MB, a vertically transmitted endosymbiont of Anopheles mosquitoes, shows strong potential as a malaria control agent due to its ability to inhibit Plasmodium development within the mosquito host.
Fidel Gabriel Otieno, Priscille Barreaux, Affognon Steeven Belvinos, Edward Edmond Makhulu, Thomas Ogao Onchuru, Anne Wambui Wairimu, Stancy Mandere Omboye, Cynthia Nyambura King’ori, Bonoukpoè Mawuko Sokame, Anthony Kebira Nyamache, Jeremy Keith Herren   +10 more
doaj   +5 more sources

First identification of Microsporidia MB in Anopheles coluzzii from Zinder City, Niger [PDF]

Parasites & Vectors
Background Malaria, a disease transmitted by Anopheles mosquitoes, is a major public health problem causing millions of deaths worldwide, mostly among children under the age of 5 years.
Lamine Mahaman Moustapha, Illiassou Mamane Sadou, Ibrahima Issa Arzika, Laminou Ibrahim Maman, Michel K. Gomgnimbou, Maurice Konkobo, Abdoulaye Diabate, Etienne Bilgo   +7 more
doaj   +5 more sources

The Plasmodium transmission-blocking symbiont, Microsporidia MB, is vertically transmitted through Anopheles arabiensis germline stem cells. [PDF]

PLoS Pathogens
Microsporidia MB is a promising candidate for developing a symbiont-based strategy for malaria control because it disrupts the capacity of An. arabiensis to transmit the Plasmodium parasite.
Thomas Ogao Onchuru, Edward Edmond Makhulu, Purity Cassandra Ronnie, Stancy Mandere, Fidel Gabriel Otieno, Joseph Gichuhi, Jeremy Keith Herren   +6 more
doaj   +5 more sources

Maximizing horizontal transmission through mating: increased mating frequency and mating competitiveness associated with Microsporidia MB-infected Anopheles arabiensis males [PDF]

Malaria Journal
Background Microsporidia MB is a naturally occurring symbiont in Anopheles arabiensis mosquitoes that inhibits the development of Plasmodium. It is transmitted both vertically and horizontally, enabling its spread within mosquito populations.
Tracy Maina, Aclaine Shisia, Joseph Gichuhi, Joel L. Bargul, Jeremy K. Herren, Tullu Bukhari   +5 more
doaj   +5 more sources

Seasonal variation of Microsporidia MB infection in Anopheles gambiae and Anopheles coluzzii in two different geographical localities in Benin [PDF]

Malaria Journal
Background Microsporidia MB, a naturally occurring Anopheles symbiont was shown to strongly impair Plasmodium transmission without imposing deleterious fitness effects on larval development, fecundity, adult survival, and adult sex ratio, and for these ...
Genevieve Tchigossou, Michel Lontsi-Demano, Eric Tossou, Pierre-Marie Sovegnon, Romaric Akoton, Danahe Adanzounon, Camille Dossou, Massioudou Koto, Azarath Ogbon, Marie Gouété, Godfrey Nattoh, Rousseau Djouaka   +11 more
doaj   +5 more sources