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Phosphorylation of Microtubule‐Associated Proteins [PDF]

European Journal of Biochemistry, 1976
1. Tubulin is not an adenosine-3':5'-monophosphate-dependent (cyclic-AMP-dependent) protein kinase. Both entities have been clearly separated by sucrose gradient ultracentrifugation. With a tubulin preparation obtained by the polymerization-depolymerization technique protein kinase had a sedimentation coefficient of 8.7 S whereas tubulin sedimented ...
L. Rappaport, Jean François LETERRIER, Alain Virion, Jacques Nunez   +3 more
openalex   +4 more sources

Construction and validation of co-expression vector for rice alpha tubulin and microtubule associated protein respectively fused with fluorescent proteins [PDF]

PeerJ
Microtubule (MT) consists of α-tubulin and β-tubulin. The dynamic instability regulated by various microtubule associated proteins (MAPs) is essential for MT functions.
Chenshan Xu, Xiaoli Zhu, Aihong Xu, Jian Song, Shuxia Liang   +4 more
doaj   +3 more sources

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse [PDF]

eLife
From a cohort of 167 infertile patients suffering from multiple morphological abnormalities of the flagellum (MMAF), pathogenic bi-allelic mutations were identified in the CCDC146 gene.
Jana Muroňová, Zine Eddine Kherraf, Elsa Giordani, Emeline Lambert, Simon Eckert, Caroline Cazin, Amir Amiri-Yekta, Magali Court, Geneviève Chevalier, Guillaume Martinez, Yasmine Neirijnck, Francoise Kühne, Lydia Wehrli, Nikolai Klena, Virginie Hamel, Lisa De Macedo, Jessica Escoffier, Paul Guichard, Charles Coutton, Selima Fourati Ben Mustapha, Mahmoud Kharouf, Anne-Pacale Bouin, Raoudha Zouari, Nicolas Thierry-Mieg, Serge Nef, Stefan Geimer, Corinne Loeuillet, Pierre F Ray, Christophe Arnoult   +28 more
doaj   +2 more sources

Manipulation of Host Microtubule Networks by Viral Microtubule-Associated Proteins

Viruses, 2022
Diverse DNA and RNA viruses utilize cytoskeletal networks to efficiently enter, replicate, and exit the host cell, while evading host immune responses. It is well established that the microtubule (MT) network is commonly hijacked by viruses to traffic to
Dahee Seo, Don B. Gammon
doaj   +1 more source

The Roles of Microtubule-Associated Protein 4 in Wound Healing and Human Diseases

Frontiers in Bioscience-Landmark, 2023
Microtubules (MTs) are essential structural elements of cells. MT stability and dynamics play key roles in integrity of cell morphology and various cellular activities.
Qiquan Chen, Junhui Zhang, Zhiqiang Song, Yuesheng Huang   +3 more
doaj   +1 more source

Dystrophin is a microtubule-associated protein [PDF]

Journal of Cell Biology, 2009
Cytolinkers are giant proteins that can stabilize cells by linking actin filaments, intermediate filaments, and microtubules (MTs) to transmembrane complexes. Dystrophin is functionally similar to cytolinkers, as it links the multiple components of the cellular cytoskeleton to the transmembrane dystroglycan complex.
Amisha Mehta, Victoria Tate, James M. Ervasti, James M. Ervasti, Evelyn Ralston, Jill L. Humston, Kurt W. Prins   +6 more
openaire   +3 more sources

MAP4 as a New Candidate in Cardiovascular Disease

Frontiers in Physiology, 2020
Microtubule and mitochondrial dysfunction have been implicated in the pathogenesis of cardiovascular diseases (CVDs), including cardiac hypertrophy, fibrosis, heart failure, and hypoxic/ischemic related heart dysfunction. Microtubule dynamics instability
Lingfei Li, Qiong Zhang, Qiong Zhang, Xia Lei, Yuesheng Huang, Yuesheng Huang, Jiongyu Hu, Jiongyu Hu   +7 more
doaj   +1 more source

Microtubules and Microtubule-Associated Proteins [PDF]

Cold Spring Harbor Perspectives in Biology, 2018
Microtubules act as "railways" for motor-driven intracellular transport, interact with accessory proteins to assemble into larger structures such as the mitotic spindle, and provide an organizational framework to the rest of the cell. Key to these functions is the fact that microtubules are "dynamic." As with actin, the polymer dynamics are driven by ...
Holly V. Goodson, Erin M. Jonasson
openaire   +2 more sources

RGS14 is a Microtubule-Associated Protein [PDF]

Cell Cycle, 2005
Heterotrimeric G-proteins and their regulators are emerging as important players in modulating microtubule polymerization dynamics and in spindle force generation during cell division in C. elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it ...
Sudhir J.A. D'Souza, David P. Siderovski, Francis S. Willard, Lina Dagnino, Agnieszka Pajak, Luke Martin-McCaffrey   +5 more
openaire   +3 more sources

The Reduced Longitudinal Growth Induced by Overexpression of pPLAIIIγ Is Regulated by Genes Encoding Microtubule-Associated Proteins

Plants, 2021
There are three subfamilies of patatin-related phospholipase A (pPLA) group of genes: pPLAI, pPLAII, and pPLAIII. Among the four members of pPLAIIIs (α, β, γ, δ), the overexpression of three isoforms (α, β, and δ) displayed distinct morphological growth ...
Jin Hoon Jang, Hae Seong Seo, Ok Ran Lee
doaj   +1 more source