Results 31 to 40 of about 257,791 (336)

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source

Expression and Clinical Significance of Cytoskeleton microtubule-associated - Tau in gastric carcinoma

Journal of College of Medical Sciences-Nepal, 2015
Background and Objectives: Microtubules, the main components of spindles in the mitotic phase, can provide the suitable conditions for unlimited proliferation of tumor cells.
Chun-Hui Li, Meiling Hao, Rajina Sahi
doaj   +1 more source

Solitonic Effects of the Local Electromagnetic Field on Neuronal Microtubules [PDF]

, 2007
Current wisdom in classical neuroscience suggests that the only direct action of the electric field in neurons is upon voltage-gated ion channels which open and close their gates during the passage of ions.
Georgiev, Danko, Glazebrook, James, Papaioanou, Stelios   +2 more
core   +1 more source

Role of non-motile microtubule-associated proteins in virus trafficking

Biomolecular Concepts, 2016
Viruses are entirely dependent on their ability to infect a host cell in order to replicate. To reach their site of replication as rapidly and efficiently as possible following cell entry, many have evolved elaborate mechanisms to hijack the cellular ...
Portilho Débora M., Persson Roger, Arhel Nathalie   +2 more
doaj   +1 more source

Neuronal and Glial Distribution of Tau Protein in the Adult Rat and Monkey

Frontiers in Molecular Neuroscience, 2021
Tau is a microtubule-associated protein for which the physiological functions remain a topic of vigorous investigation. Additionally, tau is a central player in the pathogenesis of several diseases such as Alzheimer’s disease and several frontotemporal ...
Nicholas M. Kanaan, Nicholas M. Kanaan, Nicholas M. Kanaan, Tessa Grabinski   +3 more
doaj   +1 more source

Distinct Lysosomal Network Protein Profiles in Parkinsonian Syndrome Cerebrospinal Fluid. [PDF]

, 2016
BackgroundClinical diagnosis of parkinsonian syndromes like Parkinson's disease (PD), corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) is hampered by overlapping symptomatology and lack of diagnostic biomarkers, and definitive ...
Boman, Andrea, Boxer, Adam, Karydas, Anna, Kågedal, Katarina, Miller, Bruce, Rojas, Julio C, Seeley, William W, Svenningsson, Per, Svensson, Samuel   +8 more
core   +1 more source

Basal body stability and ciliogenesis requires the conserved component Poc1 [PDF]

, 2009
Centrioles are the foundation for centrosome and cilia formation. The biogenesis of centrioles is initiated by an assembly mechanism that first synthesizes the ninefold symmetrical cartwheel and subsequently leads to a stable cylindrical microtubule ...
Abal, Andersen, Avidor-Reiss, Azimzadeh, Badano, Bakowska, Balczon, Baron, Basmussen, Basto, Beisson, Berbari, Blachon, Bobinnec, Bobinnec, Broadhead, Brown, Bruns, Chad G. Pearson, Cheeseman, Culver, Dammermann, Dammermann, Daniel P.S. Osborn, Dupuis-Williams, Dutcher, Dutcher, Dutcher, Eddé, Eggenschwiler, Essner, Fry, Gaertig, Garreau de Loubresse, Gerdes, Graser, Gundersen, Hai, Hames, Hentschel, Hildebrandt, Hiraki, Jerka-Dziadosz, Kaczanowski, Keller, Keller, Kilburn, Kirkham, Kochanski, Le Clech, Leidel, Leidel, Leidel, Li, Liu, Mark Winey, Marshall, Marshall, Martinez-Campos, Matsuura, Million, Mottier-Pavie, Nakazawa, Nanney, Neuhauss, Orias, Paoletti, Pearson, Pearson, Pelletier, Peterkin, Philip L. Beales, Piperno, Rodrigues-Martins, Salisbury, Shang, Shang, Stemm-Wolf, Strnad, Thomas H. Giddings, Tobin, Tobin, Vladar, Westerfield, Wilkinson, Williams, Wloga, Woodland   +87 more
core   +2 more sources

Tau protein plays a role in the mechanism of cognitive disorders induced by anesthetic drugs

Frontiers in Neuroscience, 2023
Cognitive disorders are mental health disorders that can affect cognitive ability. Surgery and anesthesia have been proposed to increase the incidence of cognitive dysfunction, including declines in memory, learning, attention and executive function. Tau
Zheping Chen, Shenghan Wang, Zhaoqian Meng, Yuyang Ye, Guoliang Shan, Xinyue Wang, Xin Zhao, Yanwu Jin   +7 more
doaj   +1 more source

Examination of actin and microtubule dependent APC localisations in living mammalian cells [PDF]

, 2006
(provisional) Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular
Adams, A., Askham, J.M., Langford, K.J., Lee, T., Morrison, E.E.   +4 more
core   +3 more sources

The Evolution of Tau Phosphorylation and Interactions

Frontiers in Aging Neuroscience, 2019
Tau is a neuronal microtubule-associated protein (MAP) that is involved in the regulation of axonal microtubule assembly. However, as a protein with intrinsically disordered regions (IDRs), tau also interacts with many other partners in addition to ...
Nataliya I. Trushina, Lidia Bakota, Armen Y. Mulkidjanian, Armen Y. Mulkidjanian, Armen Y. Mulkidjanian, Roland Brandt, Roland Brandt, Roland Brandt   +7 more
doaj   +1 more source