Results 31 to 40 of about 189,832 (159)

Atypical, non-standard functions of the microtubule associated Tau protein

Acta Neuropathologica Communications, 2017
Since the discovery of the microtubule-associated protein Tau (MAPT) over 40 years ago, most studies have focused on Tau’s role in microtubule stability and regulation, as well as on the neuropathological consequences of Tau hyperphosphorylation and ...
Ioannis Sotiropoulos, Marie-Christine Galas, Joana M. Silva, Efthimios Skoulakis, Susanne Wegmann, Mahmoud Bukar Maina, David Blum, Carmen Laura Sayas, Eva-Maria Mandelkow, Eckhard Mandelkow, Maria Grazia Spillantini, Nuno Sousa, Jesus Avila, Miguel Medina, Amrit Mudher, Luc Buee   +15 more
doaj   +1 more source

MAP2 phosphorylation: mechanisms, functional consequences, and emerging insights

Frontiers in Cellular Neuroscience
Microtubule-associated protein 2 (MAP2) is a key regulator of cytoskeletal dynamics and neuronal function. It stabilizes microtubules, shapes dendrites, influences synaptic plasticity, and regulates transportation and protein synthesis through its ...
Jiali Lyu, Jiali Lyu, Andrew G. DeMarco, Robert A. Sweet, Robert A. Sweet, Robert A. Sweet, Melanie J. Grubisha, Melanie J. Grubisha   +7 more
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An in vitro Microscopy-based Assay for Microtubule-binding and Microtubule-crosslinking by Budding Yeast Microtubule-associated Protein

Bio-Protocol, 2018
In this protocol, we describe a simple microscopy-based method to assess the interaction of a microtubule-associated protein (MAP) with microtubules. The interaction between MAP and microtubules is typically assessed by a co-sedimentation assay, which ...
Yili Zhu, Weimin Tan, Wei-Lih Lee
doaj   +1 more source

Enhanced expression of microtubule-associated protein 7 functioned as a contributor to cervical cancer cell migration and is predictive of adverse prognosis

Cancer Cell International, 2020
Background Cervical cancer (CC) is one of the most common female malignancies over the world. Microtubule-associated protein 7 (MAP7) belongs to the family of microtubule-associated proteins (MAPs) which involve in microtubule dynamics and are critical ...
Ning Tang, Dan Lyu, Jian-Fang Chang, Zhi-Tao Liu, Yan Zhang, Hai-Ping Liu   +5 more
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Investigations of Microtubule-associated Protein 2 Gene Expression in Spinal Muscular Atrophy

Journal of Pediatric Research, 2019
Aim:Spinal muscular atrophy (SMA) is a devastating genetic disease in childhood andff is caused by the absence of functional survival motor neuron (SMN) protein, which leads to impairments of the cytoskeleton, especially in neurons.
Gamze Bora, Ceren Sucularlı, Niko Hensel, Peter Claus, Hayat Erdem Yurter   +4 more
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The Salix SmSPR1 Involved in Light-Regulated Cell Expansion by Modulating Microtubule Arrangement

Frontiers in Cell and Developmental Biology, 2019
Light signaling and cortical microtubule (MT) arrays are essential to the anisotropic growth of plant cells. Microtubule-associated proteins (MAPs) function as regulators that mediate plant cell expansion or elongation by altering the arrangements of the
Liu Xiaoxia, Jianguo Zhang, Jianguo Zhang, Jianguo Zhang, Sui Jinkai, Luo Ying, Rao Guodong   +6 more
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Barley ROP-Interactive Partner-a organizes into RAC1- and MICROTUBULE-ASSOCIATED ROP-GTPASE ACTIVATING PROTEIN 1-dependent membrane domains

BMC Plant Biology, 2020
Background Small ROP (also called RAC) GTPases are key factors in polar cell development and in interaction with the environment. ROP-Interactive Partner (RIP) proteins are predicted scaffold or ROP-effector proteins, which function downstream of ...
Caroline Hoefle, Christopher McCollum, Ralph Hückelhoven   +2 more
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Microtubule-associated type II protein kinase A is important for neurite elongation. [PDF]

PLoS ONE, 2013
Neuritogenesis is a process through which neurons generate their widespread axon and dendrites. The microtubule cytoskeleton plays crucial roles throughout neuritogenesis.
Yung-An Huang, Jun-Wei Kao, Dion Tzu-Huan Tseng, Wen-Shin Chen, Ming-Han Chiang, Eric Hwang   +5 more
doaj   +1 more source

RGS14 is a Microtubule-Associated Protein [PDF]

Cell Cycle, 2005
Heterotrimeric G-proteins and their regulators are emerging as important players in modulating microtubule polymerization dynamics and in spindle force generation during cell division in C. elegans, D. melanogaster and mammals. We recently demonstrated that RGS14 is required for completion of the first mitotic division of the mouse embryo, and that it ...
Luke, Martin-McCaffrey, Francis S, Willard, Agnieszka, Pajak, Lina, Dagnino, David P, Siderovski, Sudhir J A, D'Souza   +5 more
openaire   +2 more sources

Non-microtubular localizations of microtubule-associated protein 6 (MAP6).

PLoS ONE, 2014
MAP6 proteins (MAP6s), which include MAP6-N (also called Stable Tubule Only Polypeptide, or STOP) and MAP6d1 (MAP6 domain-containing protein 1, also called STOP-Like protein 21 kD, or SL21), bind to and stabilize microtubules.
Sylvie Gory-Fauré, Vanessa Windscheid, Jacques Brocard, Sylvie Montessuit, Ryouhei Tsutsumi, Eric Denarier, Yuko Fukata, Christophe Bosc, Julie Delaroche, Nora Collomb, Masaki Fukata, Jean-Claude Martinou, Karin Pernet-Gallay, Annie Andrieux   +13 more
doaj   +1 more source