Results 261 to 270 of about 199,967 (323)

SEC‐SAXS/MC Ensemble Structural Studies of the Microtubule Binding Protein Cdt1 Show Monomeric, Folded‐Over Conformations

open access: yesCytoskeleton, EarlyView.
ABSTRACT Cdt1 is a mixed folded protein critical for DNA replication licensing and it also has a “moonlighting” role at the kinetochore via direct binding to microtubules and the Ndc80 complex. However, it is unknown how the structure and conformations of Cdt1 could allow it to participate in these multiple, unique sets of protein complexes.
Kyle P. Smith   +9 more
wiley   +1 more source

CITK modulates BRCA1 recruitment at DNA double strand breaks sites through HDAC6. [PDF]

open access: yesCell Death Dis
Iegiani G   +9 more
europepmc   +1 more source

TRiC Is a Structural Component of Mammalian Sperm Axonemes

open access: yesCytoskeleton, EarlyView.
ABSTRACT The TRiC chaperonin is responsible for folding ~5%–10% of the proteome in eukaryotic cells. Our recent cryo‐electron microscopy studies of axonemes from diverse mammalian cell types led to the surprising discovery that a fully assembled TRiC chaperonin is a structural component of mammalian sperm flagella, where it is tethered to the radial ...
Alan Brown   +3 more
wiley   +1 more source

Phosphorylation at the Helm: Kinase‐Mediated Regulation of Primary Cilia Assembly and Disassembly

open access: yesCytoskeleton, EarlyView.
ABSTRACT The primary cilium serves as an antenna of most vertebrate cells and is important for conveying cues from several signaling pathways into appropriate cellular responses during development and homeostasis. Cilia assembly and disassembly processes are thought to be strictly controlled; however, the precise nature of molecular events underlying ...
Andrea Lacigová, Lukáš Čajánek
wiley   +1 more source

Microtubule-modulating drugs alter sensitivity to isoflurane in mice. [PDF]

open access: yesBMC Anesthesiol
Li N   +17 more
europepmc   +1 more source

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