Results 111 to 120 of about 331,243 (309)

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

A simple automated method for continuous fieldwise measurement of microvascular hemodynamics

, 2018
Microvascular perfusion dynamics are vital to physiological function and are frequently dysregulated in injury and disease. Typically studies measure microvascular flow in a few selected vascular segments over limited time, failing to capture spatial and
Klaunig, James E., Dunn, Kenneth W., Clendenon, Sherry G, Glazier, James Alexander, Hoene, R A Von, Mang, H, Fu, X, Martinez, Mesha, Sluka, James Patrick, Clendenon, J L, Filson, A J, Winfree, S   +11 more
core   +1 more source

A U‐shaped Microfluidic Platform for Culturing Vascularized Colorectal Cancer Spheroids Reveals Tumor–Endothelial Crosstalk and Invasion‐Associated Remodeling

Advanced Materials Technologies, EarlyView.
A closed U‐shaped microfluidic platform symmetrically embeds a single, size‐controlled HT29 colorectal cancer spheroid within a GFP‐HUVEC‐laden fibrin matrix. HT29 spheroids are associated with hyper‐branched endothelial network remodeling, while vascularized co‐culture is accompanied by anisotropic protrusive growth and EMT‐like marker changes in the ...
G. Cretti, M. Ballerini, A. Mantegazza, P. Occhetta, M. Rasponi   +4 more
wiley   +1 more source

SMAD3 rs17228212 Polymorphism Is Associated with Advanced Carotid Atherosclerosis in a Slovenian Population

Biomedicines
Smad proteins influence the TGFβ signaling pathway, which plays an important role in the progression of atherosclerosis. The aim of our study was to investigate the association between the rs17228212 polymorphism of the SMAD3 gene and advanced carotid ...
David Petrovič, Jernej Letonja, Danijel Petrovič   +2 more
doaj   +1 more source

Effects of hemodialysis on blood volume, macro- and microvascular function

, 2020
BACKGROUND Vascular dysfunction is considered to spur the progression of cardiovascular disease in hemodialysis (HD) patients. Whether the HD procedure itself contributes to vascular dysfunction remains incompletely investigated.
Haider, Thomas, Nägele, Matthias P, Ruschitzka, Frank, Barthelmes, Jens, Nägele, Matthias P., Flammer, Andreas J, Sudano, Isabella, Bonani, Marco, Flammer, Andreas J., Cantatore, Silviya, Montero, David   +10 more
core   +1 more source

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Strategic Design of Soft Actuators in Translational Medical Robotics for Human‐Centered Healthcare

Advanced Robotics Research, EarlyView.
Soft robotics enables biocompatible, compliant medical devices, but clinical translation requires design‐driven engineering beyond materials. This perspective reviews implantable, surgical, and wearable systems by actuation mechanism, highlighting how optimized architectures and integration improve mechanical interfacing, adaptability, and durability ...
Ho Jun Jin, Jimin Kim, Inho Kim, Bong Hoon Kim   +3 more
wiley   +1 more source

Autonomous Navigation of Pollen‐Inspired Magnetic Microrobots for Biomedical Applications

Advanced Robotics Research, EarlyView.
A sunflower pollen‐inspired magnetic microrobot enables controlled rolling navigation in vessel‐like environments. Its open geometry reduces hydrodynamic drag, while vision‐based closed‐loop control, shortest‐path planning, and reinforcement learning support target‐reaching and maze navigation with microrobot‐scale accuracy, highlighting a route toward
Ali Anil Demircali, Abdurrahim Yilmaz, Meysam Keshavarz, Jinshi Zhao, Ara Darzi, Eric Yeatman, Burak Temelkuran   +6 more
wiley   +1 more source

Tracheal Replacement: A Scoping Review

The Surgery Journal
Objective To summarize patient characteristics and outcomes for the historical and current methods of long-segment tracheal replacement in humans.
Darin T. Johnston, David B. Powers, Matthew G. Hartwig, Russel R. Kahmke, Linda C. Cendales   +4 more
doaj   +1 more source