Results 101 to 110 of about 70,906 (304)

Ovariectomy Induces Selective Alterations in Dura Mater Blood and Lymphatic Microvascular Network Architecture in Mice

Cells
Ovarian hormones are essential regulators of vascular homeostasis, yet their deficiency’s effects on the meningeal microvasculature remain incompletely understood. We used high-resolution imaging to assess the cranial dura mater (CDM) blood and lymphatic
Olga V. Glinskii, Imad Eddine Toubal, Leike Xie, Sunilima Sinha, Kannappan Palaniappan, Vladislav V. Glinsky   +5 more
doaj   +1 more source

Stem Cell Repair of the Microvascular Damage in Stroke

Cells, 2020
Stroke is a life-threatening disease that leads to mortality, with survivors subjected to long-term disability. Microvascular damage is implicated as a key pathological feature, as well as a therapeutic target for stroke.
Madeline Saft, Bella Gonzales-Portillo, You Jeong Park, Blaise Cozene, Nadia Sadanandan, Justin Cho, Svitlana Garbuzova-Davis, Cesar V. Borlongan   +7 more
doaj   +1 more source

Morphologic and morphometric study on microvasculature of developing mouse kidneys

, 2018
A proper morphogenesis of the renal microvasculature is crucial not only for fulfilling the renal function but also to slow down the progression of chronic kidney disease in adulthood.
Jie Yang, Jesper Skovhus Thomsen, Arne Andreasen, Shi-Jie Chang, Kai-Yue Wang, Jie Zhang, Jing Cong, Ling Gu, Xiao-Yue Zhai   +8 more
core   +1 more source

Myocardial infarction coincides with increased NOX2 and Nε-(carboxymethyl) lysine expression in the cerebral microvasculature

, 2021
Background Myocardial infarction (MI) is associated with mental health disorders, in which neuroinflammation and cerebral microvascular dysfunction may play a role. Previously, we have shown that the proinflammatory factors N ε-(carboxymethyl)lysine (CML)
Schalkwijk, C.G.; id_orcid, Korn, Amber, Niessen, Hans W. M., Simsek, S., Krijnen, P.A.J., Schalkwijk, C.G., Simsek, Suat, Niessen, H.W.M., Krijnen, Paul A. J., Korn, A., Baylan, U., Schalkwijk, Casper G., Baylan, Umit   +12 more
core   +1 more source

Animal models of chronic thromboembolic pulmonary hypertension

Animal Models and Experimental Medicine, EarlyView.
Current animal models of CTEPH. Created using BioRender.com. Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare, yet life‐threatening disorder characterized by persistent pulmonary vascular obstruction and elevated pulmonary artery pressure, with progressive remodeling and subsequent right heart failure.
Yong‐Jian Zhu, Lin‐Chao Zhou, Xiao‐Xue Zhang, Xiao‐Yang Ren, Yi Yan, Shao‐Fei Liu   +5 more
wiley   +1 more source

VASCULAR BED PECULIAR PROPERTIES IN PATIENTS WITH ISCHEMIC HEART DISEASE AND ARTERIAL HYPERTENSION. ROLE OF ANTIPLATELET THERAPY

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study state of vascular wall within different levels of vascular bed in patients with arterial hypertension (HT) and ischemic heart disease (IHD), and the possibility of the correction of revealed disorders with antiplatelet agent — clopidogrel ...
L. A. Haisheva, S. V. Shlyk
doaj   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Lipocalin 2 deficiency impacts angiogenesis after ischemia in vivo and in vitro

Vascular Biology
Therapeutic neovascularization is a promising therapy option for patients with peripheral arterial disease. We followed in time the gene expression after induction of hind limb ischemia in mice with different patterns of blood flow restoration and ...
L Zhang, Z Aref, H A B Peters, M R de Vries, A Y Nossent, P H A Quax   +5 more
doaj   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Endothelial Cell Mechano-Metabolomic Coupling to Disease States in the Lung Microvasculature

Frontiers in Bioengineering and Biotechnology, 2019
Lungs are the most vascular part of humans, accepting the totality of cardiac output in a volume much smaller than the body itself. Due to this cardiac output, the lung microvasculature is subject to mechanical forces including shear stress and cyclic ...
David Wu, Konstantin Birukov
doaj   +1 more source