Results 131 to 140 of about 70,906 (304)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Volumetric imaging of the tumor microvasculature reflects outcomes and genomic states of clear cell renal cell carcinoma

The Journal of Pathology: Clinical Research
Tumor structure is heterogeneous and complex, and it is difficult to obtain complete characteristics by two‐dimensional analysis. The aim of this study was to visualize and characterize volumetric vascular information of clear cell renal cell carcinoma ...
Yuta Kaneko, Tsukasa Masuda, Kimiharu Takamatsu, Shuji Mikami, Kohei Nakamura, Hiroshi Nishihara, Ryuichi Mizuno, Nobuyuki Tanaka, Mototsugu Oya   +8 more
doaj   +1 more source

Quantitative characterization of tumor microvasculature using dynamic contrast-enhanced MRI

, 2003
Dynamic contrast-enhanced MRI is a powerful tool for characterizing tumor microvasculature. It can play an important role in modifying the angiogenic process as a therapeutic strategy.
Jackson, A.
core   +1 more source

Robust increase in supply by vessel dilation in globally coupled microvasculature

, 2019
Neuronal activity induces changes in blood flow by locally dilating vessels in the brain microvasculature. How can the local dilation of a single vessel increase flow-based metabolite supply, given that flows are globally coupled within microvasculature?
Alim, K., Meigel, F., Cha, P., Brenner, M.   +3 more
core   +1 more source

Unsupervised phenotyping of the periodontal architecture through high‐dimensional clustering of electronic health records: A multicenter study

Journal of Periodontology, EarlyView.
Abstract Background To identify novel periodontal phenotypes using unsupervised machine learning on a large‐scale, multicenter cohort, specifically characterizing disease patterns based on the “periodontal architecture” of localized structural failures (tooth mobility and molar furcation defects) rather than global severity averages alone. Methods This
Georgios S. Chatzopoulos, Larry F. Wolff
wiley   +1 more source

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is a nearly lethal neoplasm. It is a remarkably stroma-rich, vascular-poor and hypo-perfused tumour, which prevents efficient drug delivery.
Ardito-Abraham, C. M., Wu, Y., Tuveson, D. A., Wei, Y., Zhou, P., Yi, Q., Han, X., Liu, J. O., Li, J., Maitra, A., Saiyin, H., Fang, Y., Lou, W., Yu, L.   +13 more
core   +1 more source

LncRNA NORAD Enhances Inflammatory Injury in Sepsis‐Associated Acute Lung Damage Through miR‐150‐5p/STAT1‐Dependent NF‐κB Activation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Acute lung injury (ALI) is a severe complication of sepsis, yet the role of lncRNA NORAD in its pathogenesis remains unclear. Using LPS‐stimulated BEAS‐2B and HBEC3‐KT cells as well as cecal ligation and puncture (CLP)‐induced ALI models in C57BL/6 mice, we found that NORAD expression was markedly upregulated and promoted cell injury ...
Han Liu, Xi‐Xi Chen, Gui‐Hua Wei, Feng Li, Hai‐Yan Zong   +4 more
wiley   +1 more source

Quantification of retinal microvasculature

, 2020
Optical coherence tomography angiography (OCTA) is a relatively novel three-dimensional imaging modality, that provides images of the blood perfusion in the retina.
Engberg, Astrid Margareta Elisabet
core  

Erythema Multiforme: Immune Complex Vasculitis of the Superficial Cutaneous Microvasculature

, 1978
The specificity and incidence of deposits of immunoglobulin and complement in the walls of vessels in the superficial cutaneous microvasculature were evaluated in a prospective study of consecutive skin biopsy specimens submitted for evaluation by direct
Kazmierowski, John A, John A Kazmierowski, Kirk D Wuepper, Wuepper, Kirk D   +3 more
core   +1 more source

The Association Between Stress‐Induced Hyperglycemia Ratio and Increased Urinary Albumin Excretion in Patients With Hypertension: A Population‐Based Study

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The stress hyperglycemia ratio (SHR), a novel marker reflecting relative hyperglycemia, has been increasingly recognized for its prognostic value in cardiovascular and metabolic diseases. However, its association with early renal damage in hypertensive patients remains underexplored.
Kai‐Jun Zhang, Yun Lan, Wen‐Feng Zeng, Rong‐Ting Zhang, Zhi‐Yi Ma, Xin Zou   +5 more
wiley   +1 more source