Results 221 to 230 of about 70,906 (304)

High‐elevation adaptation and gestational hypoxia jointly shape vascular development in a rodent placenta

The Journal of Physiology, EarlyView.
Abstract figure legend We investigated how environmental hypoxia and genetic adaptation to high altitudes jointly impact the development of the placental exchange surface in ways that might protect fetal growth potential. We used wild‐derived, lab‐born North American deer mice (Peromyscus maniculatus) from low‐elevation and high‐elevation environments (
Kathryn Wilsterman, Zachary A. Cheviron, Jeffrey M. Good, Kai Gurnoe‐Brantley, Kylie E. Jewett, Katherine Kiel, Ashley M. Larson   +6 more
wiley   +1 more source

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

Dermal Microvascular Responses of Human Induced Pluripotent Stem Cell-Derived Skin Organoids to Inflammation and Injury. [PDF]

Am J Pathol
Sheets AR, McNamee SM, Lian CG, Murphy GF.   +3 more
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Prevalence and incidence of balance disorders in community-dwelling older adults: Protocol for the EPIBAS epidemiological balance study. [PDF]

PLoS One
Montero-Alía P, Fornes-Reynes A, Rodríguez-Pérez MC, Dacosta-Aguayo R, Miralles-Basseda R, Jiménez-Pascua T, Pascual-Bielsa J, Durá Mata MJ, Molleda-Marzo MM, Ramos-García L, López-Linfante VM, Doladé-Botías M, Álvarez-Álvarez M, Jiménez-González M, Montero-Alía JJ, Suárez-Hervella Á, Diez-Fadrique G, Moix-Juan Torres M, De Gea-Espinosa L, Lamonja-Vicente N, Mas-Pons L, León-Prieto C, Calderón-Larrañaga A, Manresa-Domínguez JM, Torán-Monserrat P.   +24 more
europepmc   +1 more source

A constitutive modelling framework for applications to in vivo longitudinal data: Evaluation in a 60‐day head‐down bed rest study on arterial function

The Journal of Physiology, EarlyView.
Abstract figure legend We proposed a computational constitutive modelling framework that leverages longitudinal acquisitions of haemodynamic waveforms at multiple arterial locations to achieve a biomechanical characterisation of their (micro)structural remodelling processes.
Alessandro Giudici, Karen Barchetti, Umit Gencer, Hakim Khettab, Elie Mousseaux, Carole Leguy, Tammo Delhaas, Rosa Maria Bruno, Bart Spronck, Pierre Boutouyrie   +9 more
wiley   +1 more source

Super-resolution functional photoacoustic microscopy via label-free cell tracking. [PDF]

Light Sci Appl
Zhong F, Wang Z, Lee Y, Han J, Sun N, Yang S, Ji S, Zhang HF, Sun C, Hu S.   +9 more
europepmc   +1 more source

Skeletal muscle adaptation to muscle activity and hypoxia: Differential structural and metabolic remodelling

The Journal of Physiology, EarlyView.
Abstract figure legend There has been controversy about the structural (capillary) response of skeletal muscle to altered O2 status, involving decreased supply (hypoxia) or increased demand (activity). Here we demonstrate that seven days of activation of skeletal muscle by indirect electrical stimulation led to significant expansion of the capillary ...
David Hauton, Roger W.P. Kissane, James McCullagh, Stuart Egginton   +3 more
wiley   +1 more source

Retinal Microvascular Features Assessed by Optical Coherence Tomography Angiography in Attention Deficit Hyperactivity Disorder. [PDF]

J Clin Med
Miquel-Lopez C, Garcia-Medina JJ, Lopez-Hernandez AE, Garcia-Ayuso D, Martinez-Soria J, Yane-Gauffin C, Retamero-Sanchez MLR, Hernandez-Olivares J, Del-Rio-Vellosillo M.   +8 more
europepmc   +1 more source

Experimental models of cerebral small vessel disease: Physiological constraints, translational challenges and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of cerebral small vessel disease (cSVD) pathophysiology and current modelling challenges. Left: clinical burden and key unresolved research questions. Right: neurovascular unit (NVU) architecture highlighting sites of cSVD pathology across arterioles, capillaries and venules, including interactions between endothelial ...
Sophie Beaumont, Tanya Singh, Luana Campos Soares, Mootaz M. Salman   +3 more
wiley   +1 more source