Results 231 to 240 of about 70,906 (304)
Inflammation induced by snake venoms optimizes envenomation
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustrating mechanisms underlying direct vascular absorption and subsequent movement of venom toxins into the tissues consequent to snakebite. A, snakebite into prey deposits venom toxins into the tissue interstitium, with the venom then causing acute inflammation primarily in venules.
Dirk F. van Helden +9 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic illustration of microneurography recordings used to examine the effects of local skin heating on cutaneous mechanoreceptor responses in the human foot (left panel). A microelectrode inserted into a peripheral nerve records single‐unit activity from tactile afferent fibres while controlled mechanical stimuli are applied ...
Erika E. Howe +4 more
wiley +1 more source
A microstructurally motivated framework to study autoregulation in the coronary circulation
The Journal of Physiology, EarlyView.Abstract figure legend A microstructurally motivated framework was constructed to simulate coronary autoregulation in symmetrically bifurcating trees at three myocardial depths: subepicardial (subepi), midwall and subendocardial (subendo). Wall mechanics of individual vessels are governed by a constrained‐mixture model, incorporating elastin, collagen ...
Matthew J. Eden +8 more
wiley +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
MedComm, Volume 7, Issue 7, July 2026.Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 387-402, July 2026.ABSTRACT Purpose We aim to inform the design of new diffusion MRI (dMRI) approaches for microvasculature quantification that enhance the biological specificity of imaging towards cancer. Methods We adopted simulation‐informed modelling of the vascular dMRI signal. We synthesised signals from 1500 synthetic vascular networks, for a variety of protocols (
Anna Kira Voronova +11 more
wiley +1 more source
Magnetic Resonance in Medicine, Volume 96, Issue 1, Page 238-246, July 2026.ABSTRACT Purpose To develop and evaluate a motion‐compensated diffusion imaging with phase‐contrast (MC‐DIP) technique for mitigating errors in regional cerebral blood flow (rCBF) quantification caused by physiological brain motion. Methods Diffusion‐weighted images were acquired in 11 healthy volunteers on a 3.0 T MRI system using three gradient ...
Naoki Ohno +6 more
wiley +1 more source
Amyloid‐β aggregates induce vasculopathy via ferroptosis in brain endothelial cells
Brain Pathology, Volume 36, Issue 4, July 2026.Blood–brain barrier (BBB) disruption is evident in brains with amyloidopathy. In this study, we demonstrate that amyloid β (Aβ) drives abnormal lipid metabolism and lipid droplet formation in brain endothelial cells, leading to lipid peroxidation and ferroptosis.
Suhyeon Son +7 more
wiley +1 more source
Microcirculation, Volume 33, Issue 5, July 2026.ABSTRACT Objective This study investigated the relationship between sublingual microcirculatory tortuosity, frailty index scores, and endothelial glycocalyx blood biomarkers in individuals with chronic kidney disease (CKD). Methods Sublingual microcirculatory videos were analyzed using a 0–4 tortuosity scoring scale. Plasma concentrations of syndecan‐1
Ryan A. P. Homes +6 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 12, 30 June 2026.Primary human dermal microvascular endothelial cells (HDMVECs) isolated from individuals with type 2 diabetes (T2D) exhibit dysregulated intrinsic properties, including altered morphology, reduced nitric oxide (NO) availability, and loss of endothelial identity.
James Shadiow +14 more
wiley +1 more source