Results 61 to 70 of about 63,716 (263)

Correction of endothelial dysfunction and impaired microcirculation in patients with critical ischemia of the lower extremities and a high risk of development of reperfusion-reoxygenation complications

Mìžnarodnij Endokrinologìčnij Žurnal, 2019
Background. Epidemiological studies show that critical ischemia of the lower extremities occurs in 500–1,000 patients per million population per year. About 10,000 reconstructive operations are performed annually in Ukraine for occlusive arterial lesions
O.B. Kolotylo
doaj   +1 more source

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

Advanced Science, EarlyView.
A timeline of the research history of 3D biomimetic scaffold materials and platforms. With advances in biomimetic materials and 3D scaffold technologies, their functional scope has expanded from mimicking basic physical and biochemical properties to increasingly replicating complex pathophysiological processes.
Haitao Zhao, Yuechen Han, Jie Li, Peng Luo, Lin Qi, Zhiwei Xia, Xiaosong Li, Quan Cheng, Chenshen Huang, Wantao Wu, Hao Zhang   +10 more
wiley   +1 more source

Modeling smooth muscle cell–endothelial cell crosstalk in abdominal aortic aneurysms using 3D microvessels on-chip

Vascular Biology
Abdominal aortic aneurysms (AAAs) are pathological dilations of the abdominal aorta. To date, surgical intervention has been the only option for managing large AAAs, with no pharmacological therapies to prevent growth of small aneurysms.
Philipp C Hauger, Karlijn B Rombouts, Marc Vila Cuenca, Albert van Wijk, Max C Overboom, Jan Willem Buikema, Kak Khee Yeung, Valeria V Orlova, Peter L Hordijk   +8 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Longitudinal Awake Mouse Brain Imaging Using Functional Ultrasound and Functional Ultrasound Localization Microscopy

Advanced Science, EarlyView.
Awake longitudinal multimodal ultrasound imaging integrates functional ultrasound (fUS), ultrasound localization microscopy (ULM), and functional ULM (fULM) to characterize cerebrovascular function, microvascular architecture, and flow dynamics within the same animals over time.
Zhe Huang, Yike Wang, Matthew R. Lowerison, Yue Xu, Murong Yi, Bing‐Ze Lin, YiRang Shin, Nathiya Vaithiyalingam Chandra Sekaran, Daniel A. Llano, Pengfei Song   +9 more
wiley   +1 more source

Lipoprotein (a) in the Development and Progression of Diabetic Retinopathy: A Systematic Review and Meta-Analysis

Medicina
Background and Objectives: Diabetic retinopathy (DR) is a significant complication of Diabetes Mellitus. Several studies have indicated Lipoprotein (a) [Lp(a)] plays a role in atherosclerotic alterations.
Stamatios Lampsas, Vaia Lambadiari, Chrysa Agapitou, Aikaterini Lampsa, Evangelos Oikonomou, Gerasimos Siasos, Irini Chatziralli   +6 more
doaj   +1 more source

Euglycemic Hyperinsulinemia Lowers Blood Pressure and Impedes Microvascular Perfusion More Effectively in Persons with Cardio-Metabolic Disease

Endocrines
In healthy humans, insulin at physiological concentrations exerts acute vasodilatory actions on both resistance and terminal arterioles, leading, respectively, to increased total blood flow and the microvascular network volume being perfused. The process
Zhenqi Liu, Linda A. Jahn, Eugene J. Barrett   +2 more
doaj   +1 more source

Alkylating Agent–Induced FANCL Impairment Damages Pulmonary Arterial, Venous, and Microvascular Endothelial Cells and Predisposes to PAH/PVOD

Advanced Science, EarlyView.
This study establishes a novel cisplatin‐induced rat model of PAH/PVOD and identifies a conserved mechanistic axis—FANCL impairment, DNA damage accumulation, and endothelial dysfunction—triggered by cisplatin or mitomycin C across pulmonary arteries, veins, and microvessels.
Shiyun Liu, Yufei Sun, Xinlei Wu, Haixia Chen, Shaocong Mo, Zichong Li, Yiwei Gong, Xiaoqian Shan, Yuanqi Li, Yaru Guan, Junqi Zhu, Han Yan, Min Du, Feng Wei, Peixin Ou, Ziyi Wang, Chenting Zhang, Lei Xu, Wenju Lu, Jian Wang, Kai Yang   +20 more
wiley   +1 more source

Ovariectomy Induces Selective Alterations in Dura Mater Blood and Lymphatic Microvascular Network Architecture in Mice

Cells
Ovarian hormones are essential regulators of vascular homeostasis, yet their deficiency’s effects on the meningeal microvasculature remain incompletely understood. We used high-resolution imaging to assess the cranial dura mater (CDM) blood and lymphatic
Olga V. Glinskii, Imad Eddine Toubal, Leike Xie, Sunilima Sinha, Kannappan Palaniappan, Vladislav V. Glinsky   +5 more
doaj   +1 more source

Stem Cell Repair of the Microvascular Damage in Stroke

Cells, 2020
Stroke is a life-threatening disease that leads to mortality, with survivors subjected to long-term disability. Microvascular damage is implicated as a key pathological feature, as well as a therapeutic target for stroke.
Madeline Saft, Bella Gonzales-Portillo, You Jeong Park, Blaise Cozene, Nadia Sadanandan, Justin Cho, Svitlana Garbuzova-Davis, Cesar V. Borlongan   +7 more
doaj   +1 more source