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Insights into the Origin of Metazoan Filopodia and Microvilli [PDF]
Molecular Biology and Evolution, 2013 Filopodia are fine actin-based cellular projections used for both environmental sensing and cell motility, and they are essential organelles for metazoan cells. In this study, we reconstruct the origin of metazoan filopodia and microvilli. We first report on the evolutionary assembly of the filopodial molecular toolkit and show that homologs of many ...
Pawel Burkhardt +9 more
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Role of Lipids in Morphogenesis of T-Cell Microvilli [PDF]
Frontiers in Immunology, 2021 T cells communicate with the environment via surface receptors. Cooperation of surface receptors regulates T-cell responses to diverse stimuli. Recently, finger-like membrane protrusions, microvilli, have been demonstrated to play a role in the organization of receptors and, hence, T-cell activation.
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T Cell Microvilli: Sensors or Senders? [PDF]
Frontiers in Immunology, 2019 Communication between cells is essential for multicellular life. During cognate immune interactions, T cells communicate with antigen-presenting cells (APC) via direct cell-cell contact or the release of molecules and vesicles containing T cell messages.
Hye-Ran Kim +3 more
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NHERF1 in Microvilli of Vomeronasal Sensory Neurons [PDF]
Chemical Senses, 2016 In most mammals, the vomeronasal system detects a variety of (semio)chemicals that mediate olfactory-driven social and sexual behaviors. Vomeronasal chemosensation depends on G protein-coupled receptors (V1R, V2R, and FPR-rs) that operate at remarkably low stimulus concentrations, thus, indicating a highly sensitive and efficient signaling pathway.
Bastian Henkel +7 more
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Isolation of microvilli from mammalian cells [PDF]
FEBS Letters, 1978 Microvilli have a variety of functions in animal cells. On epithelial cells of the renal tubule or small intestine, they increase the absorptive capacity of the cell, by increasing its surface area. In this instance, microvilli are concentrated at one end of the cells, in the form of ‘brush border’, and may be isolated as such and their composition ...
J.M. Graham, Baldip Kaur, C.A. Pasternak
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Direct visualization of epithelial microvilli biogenesis [PDF]
Current Biology, 2020 SUMMARYMicrovilli are actin bundle supported surface protrusions that play essential roles in diverse epithelial cell functions. To develop our understanding of microvilli biogenesis, we used live imaging to directly visualize protrusion growth at early stages of epithelial differentiation. Time-lapse data revealed that an “initiation complex” enriched
Isabella M. Gaeta +4 more
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Journal of Cell Biology, 2014 Polarized epithelial cells create tightly packed arrays of microvilli in their apical membrane, but the fate of these microvilli is relatively unknown when epithelial cell polarity is lost during wound healing. In this issue, Klingner et al. (2014. J. Cell Biol.
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Microvilli set the stage for T-cell activation [PDF]
Proceedings of the National Academy of Sciences, 2016 T cells are a major cellular component of the adaptive immune system. In particular, the recent wave of cancer immunotherapies that target the patient’s own T cells to attack malignant tumors have put the spotlight on T-cell antigen receptors (TCRs).
Lawrence E. Samelson, Jason Yi
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Dynamical Control of the Shape and Size of Stereocilia and Microvilli [PDF]
Biophysical Journal, 2007 We discuss theoretically the shape of actin-based protrusions such as stereocilia or microvilli that have important functions in many biological systems. These linear protrusions are dynamical structures continuously renewed by treadmilling: actin polymerizes at the tip of the cilium and depolymerizes in its bulk. They also often have a well-controlled
Prost, Jacques +2 more
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Sphingomyelin clustering is essential for the formation of microvilli [PDF]
Journal of Cell Science, 2013 Cellular architectures require regulated mechanisms to correctly localize the appropriate plasma membrane lipids and proteins. Microvilli are dynamic, filamentous-actin based protrusions of the plasma membrane in the apical membrane of epithelial cells. However, it remains poorly understood how their formation is regulated.
Junichi Ikenouchi +4 more
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