Results 71 to 80 of about 25,148 (265)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Impact of Drying Process on Grindability and Physicochemical Properties of Celery

Foods
The objective of this study was to evaluate the impact of various drying methods: freeze drying, vacuum drying, convection drying, and convection-microwave drying at microwave powers of 50 W and 100 W, along with process temperatures (40 °C, 60 °C, and ...
Stanisław Rudy, Dariusz Dziki, Beata Biernacka, Renata Polak, Andrzej Krzykowski, Anna Krajewska, Renata Stanisławczyk, Mariusz Rudy, Jagoda Żurek, Grzegorz Rudzki   +9 more
doaj   +1 more source

Optimization of microwave-vacuum drying processing parameters on the physical properties of dried Saskatoon berries

Open Agriculture, 2016
The objective of this study is to optimize the microwave-vacuum drying parameters (microwave power, drying time and fruit load) on the physical properties of dried Saskatoon berries.
Meda Venkatesh, Mitra Pranabendu, Lee Jong Hyeouk, Chang Kyu Seob   +3 more
doaj   +1 more source

Rapid Measurement of Candida utilis Dry Weight with Microwave Drying

Journal of Food Protection, 1985
A microwave oven has been used to measure biomass concentration and construct a growth curve for Candida utilis ATCC 1084. Drying curve results show that when a sample was exposed to microwave radiation for 15 min, microwave and air oven dry weight results are within 4 mg of one another when dried at the "cook" power setting (approximately 630 W at ...
Mark A, Buono, L E, Erickson
openaire   +2 more sources

A Radioresistant‐Tumor‐Targeted Nanoparticle for X‐Ray‐Controlled Nitric Oxide Release to Potentiate Radiotherapy

Advanced Science, EarlyView.
The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang, Xiaoyan Yin, Ting Wang, Hongfu Zhao, Zhipeng Zhao, Jinbao Wang, Cheng Tao, Xuanchu Ge, Yanze Li, Linlin Liu, Fuxin Xue   +10 more
wiley   +1 more source

Advances in microwave drying for fruits and vegetables based on quality-efficiency synergistic optimization

Shipin yu jixie
Fruit and vegetable drying constitutes a critical step in food processing, where process optimization should focus on both quality preservation and efficiency enhancement.
PU Zilin, LI Mengqing, ZHANG Xuetao, LI Mengyao, YANG Xuhai, ZHANG Qian   +5 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Convective Drying of Apple Enhanced with Microwaves and Ultrasound—Process Kinetics, Energy Consumption, and Product Quality Approach

Applied Sciences
This research explores the drying kinetics of apples, evaluating the impact of convective drying (CV), ultrasonically assisted convective drying (CVUS), and convective–microwave processes (CVMW1 and CVMW2) on energy consumption, drying time, temperature ...
Grzegorz Musielak, Monika Mieszczakowska-Frąc, Dominik Mierzwa   +2 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Ultrasound‐Actuated Gene Editing in Human Kidney Organoids

Advanced Science, EarlyView.
Peptide‐stabilized nanoemulsions enable spatially controlled, ultrasound‐triggered delivery of gene‐editing proteins deep within human kidney organoid tissues. Focused acoustic pulses drive droplet vaporization, propelling cargo into target renal cells while preserving native tissue microarchitecture. This non‐viral platform improves both the depth and
Michael A. Miller, Nicole Vo, Utkarsh, Ivan Sokirniy, Justin Pritchard, Benjamin S. Freedman, Scott H. Medina   +6 more
wiley   +1 more source