Results 211 to 220 of about 151,098 (403)

State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna, Amitava Mitra, Matthew L. Zierhut, Lilly East, Chandra Durairaj   +4 more
wiley   +1 more source

Seizure treatment in children: can intranasal midazolam be used without an atomizer? [PDF]

Einstein (Sao Paulo)
Rosa KD, Forcelini CM, Lorenzetti DM, Cella MA, Galera MC, de Carvalho E Souza VAF, Linden R, Bertol CD.   +7 more
europepmc   +1 more source

Respiratory Depressant Effects of Different Doses of Midazolam and Lack of Reversal with Naloxone-A Double-Blind Randomized Study

, 1983
Alain Forster, Denis R. Morel, Marlies Bachmann, M Gemperlé   +3 more
openalex   +1 more source

A Population Pharmacokinetic Approach to Understand the Effect of Efavirenz on CYP3A Activity in Healthy Volunteers Using Midazolam as a Probe

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Efavirenz induces and inhibits multiple drug‐metabolizing enzymes, contributing to significant drug–drug interactions. This study quantified the impact of multiple doses of efavirenz on CYP3A activity via midazolam metabolism using a population pharmacokinetic approach.
Kimberly S. Collins, Blessed W. Aruldhas, Ingrid F. Metzger, Jessica B. L. Lu, Michael A. Heathman, Sara K. Quinney, Zeruesenay Desta   +6 more
wiley   +1 more source

Association between the use of midazolam, fentanyl, propofol, ketamine, and dexmedetomidine and the incidence of delirium in elderly patients in intensive care units: a systematic review. [PDF]

Sao Paulo Med J
Santos WSD, Carrión-Torres O, Mussalem MGVB, Baptista VS, Yarak S.   +4 more
europepmc   +1 more source

Bispectral Analysis Measures Sedation and Memory Effects of Propofol, Midazolam, Isoflurane, and Alfentanil in Healthy Volunteers

Anesthesiology, 1997
P. Glass, M. Bloom, L. Kearse, C. Rosow, P. Sebel, P. Manberg   +5 more
semanticscholar   +1 more source

Comparative Analysis of Isavuconazole DDIs With Other Azole Antifungal Drugs and PBPK Model‐Informed Dosing Recommendations for Anticancer Drugs

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Isavuconazole is a broad‐spectrum triazole approved for the treatment of invasive aspergillosis or mucormycosis in adults and children aged ≥ 1 year. Current prescribing information lacks guidance regarding the co‐administration of isavuconazole with anticancer drugs–limited by the availability of clinical drug–drug interaction (DDI) data in ...
Theunis C. Goosen, Xiaofeng Wu, Jian Lin, Narayan Cheruvu, Susan R. Raber, Maria Lavinea Novis de Figueiredo, Manthena V. S. Varma   +6 more
wiley   +1 more source

Remimazolam as a Novel Option for Procedural Sedation: A Narrative Review. [PDF]

Cureus
Ziembicki H, Skrzypska N, Wróblewska J, Zagaja K, Wasilewska P, Wojtczak O.   +5 more
europepmc   +1 more source

Midazolam-Morphine Sedative Interaction in Patients

, 1989
Mark Tverskoy, G Fleyshman, J. EZRY, Edwin L. Bradley, Igor Kissin   +4 more
openalex   +1 more source

The Effectiveness of Midazolam for Preventing Postoperative Nausea and Vomiting: A Systematic Review and Meta-Analysis

Anesthesia and Analgesia, 2016
E. Ahn, Hyun Kang, G. Choi, C. Baek, Y. Jung, Y. Woo   +5 more
semanticscholar   +1 more source