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The pharmacokinetics of midazolam in man
European Journal of Clinical Pharmacology, 1981 Midazolam, a new water-soluble benzodiazepine, was administered as: i) 5 mg intravenously, ii) a 10-mg oral solution and iii) a 10-mg oral tablet, to six volunteers whose informed consent had been obtained.
Maree T Smith, Smith M T, Eadie M J
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Clinical Pharmacology and Therapeutics, 1981
The effect-kinetics of the new benzodiazepine midazolam was evaluated in six subjects after single oral (7.5 and 15 mg) and intravenous (0.075 mg/kg) doses and infusion programs. The drug is bound to plasma proteins by 94%, and less than 0.5% is excreted unchanged in urine.
H, Allonen, G, Ziegler, U, Klotz
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The effect-kinetics of the new benzodiazepine midazolam was evaluated in six subjects after single oral (7.5 and 15 mg) and intravenous (0.075 mg/kg) doses and infusion programs. The drug is bound to plasma proteins by 94%, and less than 0.5% is excreted unchanged in urine.
H, Allonen, G, Ziegler, U, Klotz
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Anaesthesia, 1983
Summary Midazolam, administered intramuscularly was compared with papaveretum and hyoscine for premedication in patients undergoing gynaecological surgery. Midazolam proved to be a satisfactory agent for premedication compared with papaveretum and hyoscine, producing a similar degree of sedation and anxiolysis, but causing ...
E J, McAteer, J, Dixon, J G, Whitwam
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Summary Midazolam, administered intramuscularly was compared with papaveretum and hyoscine for premedication in patients undergoing gynaecological surgery. Midazolam proved to be a satisfactory agent for premedication compared with papaveretum and hyoscine, producing a similar degree of sedation and anxiolysis, but causing ...
E J, McAteer, J, Dixon, J G, Whitwam
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Anesthesiology, 1985
Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines. It is water soluble in its acid formulation but is highly lipid soluble in vivo. Midazolam also has a relatively rapid onset of action and high metabolic clearance when compared with other benzodiazepines. The drug produces reliable hypnosis, amnesia,
J. G. Reves +3 more
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Midazolam is an imidazobenzodiazepine with unique properties when compared with other benzodiazepines. It is water soluble in its acid formulation but is highly lipid soluble in vivo. Midazolam also has a relatively rapid onset of action and high metabolic clearance when compared with other benzodiazepines. The drug produces reliable hypnosis, amnesia,
J. G. Reves +3 more
openaire +1 more source