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Neurotoxicity of midazolam in the rabbit
Pain, 1999Safe and efficient use of spinal drugs requires neurotoxicologic animal studies before ethical application. We have evaluated the neurotoxicologic interruptions of intrathecal administration of midazolam in rabbits. Eighteen white New Zealand rabbits were randomly assigned into three groups consisting of six rabbits each. In conscious animals, 0.3 ml 0.
Nejat Savci +7 more
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Midazolam and flumazenil in gastroenterologys
Acta Anaesthesiologica Scandinavica, 1990Flumazenil, a specific benzodiazepine antagonist, has been used to reverse sedation in a double‐blind, controlled study of patients undergoing upper gastrointestinal (GI) endoscopy. Forty patients in each of two centres were given a standard dose of either flumazenil (n = 40) or placebo (n = 40) after gastroscopy under midazolam sedation.
K. D. Bardhan +3 more
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The Chronic Efficacy of Midazolam
International Clinical Psychopharmacology, 1990The chronic efficacy of midazolam 15.0 mg was studied in 2 male and 10 female subjects. Only subjects with a complaint of sleep latency insomnia which was verified by polysomnography were included in the study. Following a screening and adaptation period, subjects spent 3 consecutive nights in the laboratory during the weeks of the study.
James Lamphere +5 more
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Midazolam and flumazenil in neuroanaesthesia
Acta Anaesthesiologica Scandinavica, 1990Of the numerous benzodiazepines currently available, only a few are used in anaesthetic practice. Midazolam is utilised as a premedicant, sedative, and an induction agent and produces minimal depression of ventilation or of the cardiovascular system. The anticonvulsant activity is similar to that of diazepam.
Eberhard Kochs, J. Schulte am Esch
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Flumazenil and midazolam in anaesthesia
Acta Anaesthesiologica Scandinavica, 1995Flumazenil, the first benzodiazepine antagonist, is currently used widely as an emergency drug, and has also been utilized in planned procedures, to time arousal intra‐ or post‐operatively. It is known that flumazenil, used at the end of a procedure, causes instant recovery by reversing the residual effects of, for example, midazolam.
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The use of midazolam in premedication
Acta Anaesthesiologica Scandinavica, 1990Socio‐psychological factors, such as increased anxiety in developed societies and cultures, and separation anxiety, particularly in children, justify the use of premedicants. In addition, the link between a central nervous “anxiety centre” and biochemical stress responses is blocked by an efficient anxiolytic.
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Pharmacokinetics of midazolam in the aged
European Journal of Clinical Pharmacology, 1984The pharmacokinetics of midazolam, an imidazo-benzodiazepine derivative, have been studied in 13 subjects over the age of 60 years who received the drug intravenously (0.07 mg kg-1) as an induction agent for endoscopy. Two to three days later, 6 of these subjects received 5 mg of midazolam intramuscularly, and another 6 of the subjects received 10 mg ...
Smith M.T. +4 more
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The pharmacokinetics of midazolam in man
European Journal of Clinical Pharmacology, 1981Midazolam, a new water-soluble benzodiazepine, was administered as: i) 5 mg intravenously, ii) a 10-mg oral solution and iii) a 10-mg oral tablet, to six volunteers whose informed consent had been obtained. Midazolam plasma concentrations were measured using an electron-capture gas-liquid chromatographic assay.
Smith, MT, Eadie, MJ, Brophy, TO
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