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The use of midazolam in premedication
Acta Anaesthesiologica Scandinavica, 1990Socio‐psychological factors, such as increased anxiety in developed societies and cultures, and separation anxiety, particularly in children, justify the use of premedicants. In addition, the link between a central nervous “anxiety centre” and biochemical stress responses is blocked by an efficient anxiolytic.
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The pharmacokinetics of midazolam in man
European Journal of Clinical Pharmacology, 1981Midazolam, a new water-soluble benzodiazepine, was administered as: i) 5 mg intravenously, ii) a 10-mg oral solution and iii) a 10-mg oral tablet, to six volunteers whose informed consent had been obtained. Midazolam plasma concentrations were measured using an electron-capture gas-liquid chromatographic assay.
Smith, MT, Eadie, MJ, Brophy, TO
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British Dental Journal, 1985 Pharmacokinetics of midazolam in the aged
European Journal of Clinical Pharmacology, 1984The pharmacokinetics of midazolam, an imidazo-benzodiazepine derivative, have been studied in 13 subjects over the age of 60 years who received the drug intravenously (0.07 mg kg-1) as an induction agent for endoscopy. Two to three days later, 6 of these subjects received 5 mg of midazolam intramuscularly, and another 6 of the subjects received 10 mg ...
Smith M.T. +4 more
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