Results 61 to 70 of about 2,054,147 (357)

Signatures of middle aged, nearby pulsars in the cosmic ray lepton spectrum?

, 2011
Recent data reported by the PAMELA and ATIC experiments, as well as cosmic ray lepton results from FERMI and H.E.S.S. collaborations sparked a series of papers explaining these results either by contributions of electron positron pairs to the local ...
Büsching, Ingo, deJager, Okker C.
core   +1 more source

Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]

, 2012
BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman, Erik Hrabovszky, Imre Kalló, István Likó, Miklós Sárvári, Nicole Berchtold, Norbert Solymosi, Sárvári, Miklós, Zsolt Liposits   +8 more
core   +2 more sources

Diverse Manifestations and Underlying Mechanisms of Ischemic Infarctions in Individuals Afflicted by Systemic Malignancies - A Case Series [PDF]

Liaquat National Journal of Cancer Care
This study delves into the diverse manifestations and underlying mechanisms of ischemic infarctions in individuals suffering from systemic malignancies.
Saba Zaidi, Mahzareen, Yusra Saleem, Iman Jauhar, Muhammad Mubashir   +4 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

A Cosmic Ray Positron Anisotropy due to Two Middle-Aged, Nearby Pulsars?

, 2008
Geminga and B0656+14 are the closest pulsars with characteristic ages in the ran ge of 100 kyr to 1 Myr. They both have spindown powers of the order 3e34 erg/s at present.
Barwick, Berezinskii, Boezio, Buesching, C. Venter, Caraveo, de Jager, DuVernois, Ginzburg, I. Büsching, M. S. Potgieter, Manchester, Mao, O. C. de Jager, Potgieter, Rees, Sefako, Venter   +17 more
core   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Variability in heart rate recovery measurements over 1 year in healthy, middle-aged adults. [PDF]

, 2014
This study assessed the longer-term (12-month) variability in post-exercise heart rate recovery following a submaximal exercise test. Longitudinal data was analysed for 97 healthy middle-aged adults (74 male, 23 female) from 2 occasions, 12 months apart.
Carroll, S, Ingle, L, Mellis, MG
core   +1 more source

Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle, Kiersten Ricci, Kelly Blache, Rebecca A. Marsh, Adrienne M. Hammill, Elissa Engel   +5 more
wiley   +1 more source

Determinants of short-period heart rate variability in the general population [PDF]

, 2001
Decreased heart rate variability (HRV) is associated with a worse prognosis in a variety of diseases and disorders. We evaluated the determinants of short-period HRV in a random sample of 149 middle-aged men and 137 women from the general population ...
Bolte, H.-D., Eckardstein, A. von, Hense, H. W., Kark, J. D., Kuch, Bernhard, Sapoznikov, D., Sinnreich, R.   +6 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source