Results 51 to 60 of about 467,597 (305)

Lithospheric structure in NW of Africa: Case of the Moroccan Atlas Mountains

Geodesy and Geodynamics, 2015
This study presents the outcomes of the local earthquake tomography applied in the Moroccan Atlas domains. A seismic data collected by 36 seismic and a linearized inversion technics are used for determination of local velocity structure.
Youssef Timoulali, Jabour Nacer, Hahou Youssef, Chourak Mimoun   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Integrated remote sensing and field data for lithological mapping and calcite exploration in the Middle Atlas, Morocco

Scientific African
This study focuses on the application of remote sensing techniques for litho-structural mapping and calcite index detection in the Middle Atlas of Morocco.
Abdelkhiar Ait Ali, Jaouad Choukrad, Youssef Ouahzizi, Mohammed Charroud, Hicham Si Mhamdi, Naoufal Saoud, Souhail Mounir, Abdellah Mechaqrane   +7 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Chemical, Mineralogical, and Biological Properties of Pistacia atlantica subsp. atlantica Essential Oils from the Middle Atlas of Morocco

Horticulturae
This study focused on Atlas pistachio (Pistacia atlantica subsp. atlantica), an endangered species from the Moroccan Middle Atlas, analyzing its leaves to assess their antioxidant and antimicrobial activity.
Mohammed Bassouya, Mohamed Chedadi, Mohamed El fadili, Jawhari Fatima Zahra, Younesse El-byari, Abdelaaty A. Shahat, Sonia Morya, Abdelfattah El Moussaoui, Mohammed Kara, Amina Bari   +9 more
doaj   +1 more source

Large pseudoscalar Yukawa couplings in the complex 2HDM [PDF]

, 2015
We start by presenting the current status of a complex flavour conserving two-Higgs doublet model. We will focus on some very interesting scenarios where unexpectedly the light Higgs couplings to leptons and to b-quarks can have a large pseudoscalar ...
Fontes, Duarte, Romão, Jorge C., Santos, Rui, Silva, João P.   +3 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Bordel de bled, bordel au Bled : figures rurales de la prostitution au Maroc

L’Année du Maghreb, 2010
Because too many shortcuts are taken in the study of female prostitution in the Middle Atlas, this article, taking us back to colonial and postcolonial times, will attempt to portray the phenomena in a different manner. By examining several recollections,
Mustapha Qadéry
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Effet des conditions climatiques sur le niveau du lac Sidi Ali (Moyen Atlas, Maroc)

Physio-Géo, 2011
Lake Sidi Ali is a natural lake at high altitude (2070-2080 m), without surface outlet, determined by the dam of a basalt flow. With an apparent catchment of 15.6 km2, it is fed by runoff and karst springs.
Ahmed Sayad, Saïd Chakiri, Claude Martin, Zohra Bejjaji, Hassan Echarfaoui   +4 more
doaj   +1 more source