Results 101 to 110 of about 282,480 (358)

Clinical Applications of the Pipeline Embolization Device [PDF]

, 2018
No abstract ...
Atallah, MD, Elias, Chalouhi, MD, Nohra, Daou, MD, Badih, Fitchett, BS, Evan, Jabbour, Pascal, MD, Montano, BS, Maria, Oliver, BS, Jeffrey, Rosenwasser, MD, MBA, FACS, FAHA, Robert H., Starke, MD, Robert, Tjoumakaris, MD, FAANS, Stavropoula   +9 more
core   +2 more sources

Potentiating Cerebral Perfusion Normalizes Glymphatic Dynamics in Systemic Inflammation

Advanced Science, EarlyView.
LPS‐induced systemic inflammation increases glymphatic influx but delays cervical lymphatic drainage, accompanied by AQP4 depolarization and impaired glymphatic clearance. Enhancing cerebral blood flow via the inotropic agent levosimendan effectively restored AQP4 polarization, improving glymphatic flux and amyloid‐β clearance.
Ruoyu Zhao, Bin Sun, Pengju Wei, Yingying Sun, Qianyan He, Kejia Zhang, Jun Lu, Shoujun Zhu, Yi Yang, Zhenni Guo   +9 more
wiley   +1 more source

Telencephalon vascularity in sheep (Ovis aries)

Pesquisa Veterinária Brasileira
: The studies into the vascularity of the telencephalon in Polish Merino sheep of both sexes were made on 60 cerebral hemispheres. It was found that the middle cerebral artery is the most powerful vessel supplying blood to the telencephalon.
Benedykt Skoczylas, Witold Brudnicki, Krzysztof Kirkiłło-Stacewicz, Włodzimierz Nowicki, Jan Wach   +4 more
doaj   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Acacetin protects against cerebral ischemia-reperfusion injury via the NLRP3 signaling pathway

Neural Regeneration Research, 2019
Acacetin (5,7-dihydroxy-4′-methoxyflavone), a potential neuroprotective agent, has an inhibitory effect on lipopolysaccharide-induced neuroinflammatory reactions.
Juan Bu, Shen Shi, Hui-Qin Wang, Xiao-Shan Niu, Zong-Feng Zhao, Wei-Dong Wu, Xiao-Ling Zhang, Zhi Ma, Yan-Jun Zhang, Hui Zhang, Yi Zhu   +10 more
doaj   +1 more source

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion

Stroke: Vascular and Interventional Neurology
Background Guidelines on endovascular therapy for acute ischemic stroke do not include isolated cervical internal carotid artery (cICA) occlusions. The effect of treating these lesions remains unclear.
Katrine Falkesgaard, Jakob N. Hedegaard, Jonas Jensen, Thabele M. Leslie‐Mazwi, Rolf A. Blauenfeldt, Claus Z. Simonsen   +5 more
doaj   +1 more source

The future of ischemic stroke: flow from prehospital neuroprotection to definitive reperfusion. [PDF]

, 2014
Recent advances in ischemic stroke enable a seamless transition of the patient flow from the prehospital setting to definitive reperfusion, without the arbitrary separation of therapeutic phases of ischemia based on time alone.
Ip, Hing Lung, Liebeskind, David S
core   +1 more source

Twiglike Middle Cerebral Arteries [PDF]

Neurosurgery, 2012
Ana, Rodríguez-Hernández, Susanna, Miric, Michael T, Lawton   +2 more
openaire   +2 more sources

Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy

Advanced Science, EarlyView.
MED27 is one of the 26 subunits in the human Mediator complex (MED). Neurodevelopmental disorder‐causing MED27 genetic variants induce instability of MED, leading to disrupted DNA occupancy, altered chromatin interaction, and subsequent transcriptional dysregulation of critical downstream genes, including master regulatory transcription factors ...
Nuermila Yiliyaer, Xiaocheng Li, Tianyu Guo, Haiying Zhou, Lihai Gong, Luowei Yuan, Yang Fu, Yulong Qiao, Ying Lam Lui, Nuo Chen, Pengfei Lin, Hoi Hung Cheung, Ho Ko, Linyan Meng, Xiao Chen, Yong Lei, Kin Ming Kwan, Huating Wang, Shen Gu   +18 more
wiley   +1 more source