Results 101 to 110 of about 3,362,044 (295)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
A reconsideration of what and who is middle class in South Africa [PDF]
In this paper, we revisit 'what and who' is middle class in South Africa using data collected in the 2008 National Income Dynamics Study. First we consider how to identify the middle class based on two broad definitions adopted in the international ...
Justin Visagie, Dorrit Posel
core
WHAT THE MIDDLE CLASSES DEMAND? A COMPARISON ON MIDDLE CLASSES AMONG RUSSIA AND TURKEY [PDF]
, 2016 This article examines Russian and Turkish middle classes in a comparative framework, from their historical formation to the present. In today's Russia, despite strains on the economic situation and living standards of the middle classes, they strongly ...
Kesgin, Burak
core +1 more source
OSU Middle East Studies Bulletin
, 2008 A Biannual Publication of the Middle East Studies ...
Ohio State University. Middle East Studies Center
core +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
HeliyonBackground: Physical Education (PE) classes are vital for nurturing students' social development and promoting collaboration. This study examined how primary and middle school students perceived PE classes, with a focus on collaboration, well-being and ...
Gabriele Russo +3 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Suriye'de Fransız manda yönetimine karşı siyasi mücadele:1920-1946
, 2020 In this thesis, the French mandate period in Syria and the nationalist movement against the mandate between 1920-1946 is analyzed. This thesis aims to show that the main characteristic of the Syrian political developments - political parties as ...
Uslu, Hanif
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source