Results 71 to 80 of about 5,104,116 (389)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
EU Neighbourhood policy: implications for public services and trade unions [PDF]
, 2006 The EU Neighbourhood policy creates pressures to liberalise and privatise public services.
Hall, David
core
Noninvasive ventilation in critically ill patients with the Middle East respiratory syndrome
Influenza and Other Respiratory Viruses, 2019 Noninvasive ventilation (NIV) has been used in patients with the Middle East respiratory syndrome (MERS) with acute hypoxemic respiratory failure, but the effectiveness of this approach has not been studied.
B. Alraddadi +24 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Discover SustainabilityThe study focuses on understanding the moderation effect of organizational agility in the impact of digital HRM system and digital transformation on HR efficiency in organizations intending to excel in the digital era. This study examines the association
Mo’men Hani Mahmoud +4 more
doaj +1 more source
Electricity production potential and social benefits from rice husk, a case study in Pakistan
Cogent Engineering, 2016 Pakistan has been experiencing energy crisis owing to its sole dependence on fossil fuels. Reduction in local fossil fuel reserves has led to an increase in their prices, thereby increasing the cost of electricity.
Obaidullah Mohiuddin +4 more
doaj +1 more source
Book review: Behind the veil of vice: the business andculture of sex in the Middle East [PDF]
, 2013 In Behind the Veil of Vice, Middle East expert John R. Bradley sets out to uncover the truth about the place of sex in countries including Egypt, Syria, Morocco and Yemen.
Smith, Emma
core
A Review of the 21st Century Challenges in the Food-Energy-Water Security in the Middle East
Water, 2019 Developing countries have experienced significant challenges in meeting their needs for food, energy, and water security. This paper presents a country-level review of the current issues associated with Food-Energy-Water (FEW) security in the Middle East.
M. Hameed +5 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.Patatin domain‐containing (phospho)lipases are lipid‐hydrolyzing enzymes central to metabolism, membrane remodeling, and signaling. Their activity relies on precise co‐activation mechanisms involving protein–protein interactions and conformational rearrangements.
Noopur Dubey +2 more
wiley +1 more source