Results 71 to 80 of about 773,410 (319)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Rubik Cube of the Wider Middle East. CEPS Paperback. February 2003 [PDF]
, 2003 Given the complexity and severity of the problems involved, this book asserts that a comprehensive regional initiative for the Wider Middle East is called for and proceeds to outline exactly what that would entail.
Emerson, Michael, Tocci, Nathalie
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ANTITHROMBOTIC PROPHYLAXIS IN THE MIDDLE EAST
Mediterranean Journal of Hematology and Infectious Diseases, 2011 Several factors have been proposed to explain the persistence of a high incidence of venous thromboembolism worldwide with its associated morbidity and mortality. Underutilization of anticoagulants and failure of adherence to thromboprophylaxis guidelines are emerging global health concerns.
Samir Arnaout +5 more
openaire +4 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Entegrasyon politikalarında eğitimin rolü : Suriye mülteci krizi sonrası İsveç, Almanya Türkiye karşılaştırması. [PDF]
, 2020 This study aims to produce a comparative research on integration policies of Sweden, Germany, and Turkey that host remarkable number of Syrians after the crisis in Syria which is considered as the biggest humanitarian and refugee crisis of our time. This
Erşekerci, Nesibe Burcu
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Kudüs değil, Şam: Suriye savaşı’ndaki (2011 –2017) Lübnan’dan gelen Filistinli cihatçılar. [PDF]
, 2019 Ongoing Syrian War is one of the most important historical event for both the Middle East and the world in recent history. Regional and international powers with their proxies has shaped not only Syrian politics, economy, and international relations, but
Çete, Erman
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Araştırma Görevlilerinin Bilim ve Bilimsel Etkinliklere İlişkin Algılarının Karşılaştırmalı Analizi
Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2014 Bu nicel çalışmada araştırma görevlilerinin bilime ve bilimsel etkinliklere ilişkin algıları araştırılmıştır. Daha ayrıntılı olarak bu çalışmada araştırma görevlilerinin bilim ve bilimsel etkinlikler hakkındaki görüşleri araştırma görevliliği statüsü (
Nuri KARA +3 more
doaj
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Kınrıs'ta mülkiyet sorunu 1974-2012. [PDF]
, 2012 This thesis aims to analyze the property issue in the Cyprus conflict from 1974 up to 2012 based on historical and legal factors. First of all, the historical background of the Cyprus conflict will be evaluated with its different dimensions. After the EU
Sağlam, Süheyla Hande
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