Structure‐ and Ligand‐Based Discovery of Novel 3‐Chymotrypsin‐Like Protease Nonpeptidomimetic Hits
ChemMedChem, Volume 21, Issue 7, 14 April 2026.A multistep virtual screening cascade, integrating shape‐based, ensemble docking, and quantitative structure–activity relationship (QSAR) models, was employed to screen 1.5 million compounds. This funnel identified a novel 3‐chymotrypsin‐like protease (3CLpro) inhibitor, LabMol‐499, which was experimentally validated using a Förster Resonance Energy ...
Sabrina Silva‐Mendonça +14 more
wiley +1 more source
Covid-19 and its impacts on consumer decision-making process [PDF]
, 2015 The term "virus" derives from the Latin word for "venom" and refers to a microscopic infectious agent. On the other hand, "corona" is named by its shape to look like a crown ring – the scientists who coined the word coronavirus in 1968 reasoned that ...
Harun, Amran +2 more
core
Valinomycin as a potential antiviral agent against coronaviruses: A review
Biomedical Journal, 2020 Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have been resulting in global ...
Dong Zhang +4 more
doaj +1 more source
Vaccine against Middle East respiratory syndrome coronavirus [PDF]
The Lancet Infectious Diseases, 2019 Shen, Xuejuan +3 more
openaire +5 more sources
Middle East respiratory syndrome coronavirus (MERS-CoV) in dromedary camels in Nigeria, 2015 [PDF]
, 2015 Evidence of current and past Middle East respiratory syndrome coronavirus (MERS-CoV) infection in dromedary camels slaughtered at an abattoir in Kano, Nigeria in January 2015, was sought by reverse transcription-quantitative polymerase chain reaction (RT-
Chan, MS +6 more
core +1 more source
New coronavirus outbreak. Lessons learned from the severe acute respiratory syndrome epidemic [PDF]
, 2016 System dynamics approach offers great potential for addressing how intervention policies can affect the spread of emerging infectious diseases in complex and highly networked systems.
Donado-Campos, J +2 more
core +1 more source
Coronavirus zoonozes associated with chiroptera
Ветеринария сегодня, 2018 The paper considers natural historical aspects of emerging highly dangerous coronavirus infections found in a Chirocoptera reservoir, of serious acute respiratory syndrome ("atypical pneumonia") and Middle East respiratory syndrome, their origin and ...
V. V. Makarov, D. A. Lozovoy
doaj
Emerging viral respiratory tract infections—environmental risk factors and transmission [PDF]
, 2014 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Al-Tawfiq, Jaffar A. +6 more
core +1 more source
MERS-CoV in Arabian camels in Africa and Central Asia [PDF]
, 2017 Middle East Respiratory Syndrome Coronavirus (MERS-CoV) causing infections in humans is genetically indistinguishable from the virus found in Arabian camels (dromedaries) in the Middle East. Although no primary human case of MERS was reported outside the
Chan, Samuel M.S. +7 more
core +1 more source
Association between Severity of MERS-CoV Infection and Incubation Period
Emerging Infectious Diseases, 2016 We analyzed data for 170 patients in South Korea who had laboratory-confirmed infection with Middle East respiratory syndrome coronavirus. A longer incubation period was associated with a reduction in the risk for death (adjusted odds ratio/1-day ...
Victor Virlogeux +3 more
doaj +1 more source