Results 91 to 100 of about 4,288,113 (308)
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Frontiers in PsychologyBackgroundSocial support has been identified as a key factor influencing adolescents’ engagement in physical activities. However, the relationship between middle school girls’ physical activity levels and the actual social support they receive remains ...
Mingyuan Dong +4 more
doaj +1 more source
Do Killer Electrons Affect You? [PDF]
, 2007 This full color tri-fold brochure answers questions about high energy particles in space and how they are produced, when and where they occur, and how they can affect us. It also includes lists of web and print resources for further study.
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
Education SciencesThis research synthesis, highlighting the middle level curriculum, was created as part of a working group within the American Education Research Association (AERA) Middle level Education Research Special Interest Group (MLER SIG) to advance middle level ...
Christopher Weiler +4 more
doaj +1 more source
A Preliminary Analysis of the Supply and Demand for Middle School Mathematics and Science Teachers in Virginia [PDF]
, 1999 Virginia Colleges and Universities have a major challenge to produce educated elementary and middle school students. The magnitude of this challenge can be measured by studying the number of current teachers in each grade in Virginia and the anticipated ...
Sigler, J. A.
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Navigating the Middle Grades and Preparing Students for High School Graduation [PDF]
, 2011 This brief presents preliminary findings from an exploratory study of New York City students' transitions into, through, and out of the middle grades. Our analysis reveals that students' attendance and achievement in their early schooling (fourth grade ...
Michael Kieffer +2 more
core
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source