Results 91 to 100 of about 4,280,336 (307)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A study on the impact of sports participation support on the level of sports participation of urban junior high school girls in China

Frontiers in Psychology
BackgroundSocial support has been identified as a key factor influencing adolescents’ engagement in physical activities. However, the relationship between middle school girls’ physical activity levels and the actual social support they receive remains ...
Mingyuan Dong, Mingtian Niu, Zhengxin Jiang, Yongchul Choi, Ning Li   +4 more
doaj   +1 more source

Do Killer Electrons Affect You? [PDF]

, 2007
This full color tri-fold brochure answers questions about high energy particles in space and how they are produced, when and where they occur, and how they can affect us. It also includes lists of web and print resources for further study.

core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Volcanic Aerosols Bookmark [PDF]

, 2005
This bookmark on volcanic aerosols provides a Web address for additional information and resources.

core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

A Framework for Middle Level Curriculum: A Literature Review to Support the Middle Level Education Research Special Interest Group Research Agenda

Education Sciences
This research synthesis, highlighting the middle level curriculum, was created as part of a working group within the American Education Research Association (AERA) Middle level Education Research Special Interest Group (MLER SIG) to advance middle level ...
Christopher Weiler, Steven B. Mertens, James Nagle, Stacie Pettit, Amanda Wall   +4 more
doaj   +1 more source

Navigating the Middle Grades and Preparing Students for High School Graduation [PDF]

, 2011
This brief presents preliminary findings from an exploratory study of New York City students' transitions into, through, and out of the middle grades. Our analysis reveals that students' attendance and achievement in their early schooling (fourth grade ...
Michael Kieffer, Nickisha Stephenson, William H. Marinell   +2 more
core  

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

A Scoping Literature Review on Parent Interactions with Teachers and School Environments at the Middle Level

Education Sciences
This scoping literature review explores parent interactions with teachers and school environments at the middle level, particularly how parents and teachers perceive middle school environments and parent–teacher relationships, the strategies that schools
Sarah E. Pennington, Judy H. Tang, Kent Divoll, Pamela Correll   +3 more
doaj   +1 more source