Results 41 to 50 of about 740,304 (299)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Revisiting Middle Stone Age hunting at ≠GI, Botswana: A tip cross-sectional area study

open access: yesSouthern African Field Archaeology, 2023
≠Gi was excavated almost half-a-century ago. Despite no formally published analyses of its lithic and faunal assemblages, the site has been important to discussions about technological development during the Middle Stone Age (MSA). Dating to ~77 ka, ≠Gi
Marlize Lombard, Steven Churchill
doaj   +1 more source

Goldsmith’s: Preliminary Study of a newly discovered Pleistocene site near Sterkfontein. [PDF]

open access: yes, 2007
Student Number : 9903519M - MSc research report - School of Geography, Archaeology and Environmental Studies - Faculty of ScienceGoldsmith’s is a newly discovered fossil and archaeological site 4km south-west of the famous Sterkfontein Cave Site, in ...
Mokokwe, Winnie Dipuo
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Unearthed potential: Reflecting on the past and shaping the future of Middle Stone Age research in Zimbabwe

open access: yesSouthern African Field Archaeology
Zimbabwe is home to numerous well-preserved deposits spanning from the Earlier to the Later Stone Age. However, research on the Middle Stone Age has been limited, with most studies conducted during the colonial era.
Precious Chiwara-Maenzanise
doaj   +1 more source

Investigation of Factors Affecting the Stone-Free Rate in Elderly Patients with Urinary Stones After Shock Wave Lithotripsy

open access: yesDüzce Tıp Fakültesi Dergisi, 2021
Aim: Urinary stone disease is an important disease seen in all age groups, including elderly patients. It can cause kidney failure and urinary infection problems.
Arda Taşkın Taşkıran   +3 more
doaj   +1 more source

Animal residues found on tiny Lower Paleolithic tools reveal their use in butchery [PDF]

open access: yes, 2019
Stone tools provide a unique window into the mode of adaptation and cognitive abilities of Lower Paleolithic early humans. The persistently produced large cutting tools (bifaces/handaxes) have long been an appealing focus of research in the ...
Agam, Aviad   +5 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

The Mehlman archives and the archaeology of Nasera rockshelter, Tanzania

open access: yesAfriques
Archives are increasingly recognized as a critical element in archaeological research in eastern Africa and elsewhere that, unlike excavation, are a non-destructive source of information.
Christian A. Tryon   +2 more
doaj   +1 more source

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