Results 51 to 60 of about 740,304 (299)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Critical Inventory and Associated Chronology of the Middle Stone Age and Later Stone Age in Northwest Africa

Journal of Open Archaeology Data
The study of human evolution and cultural patterns relies on empirical evidence provided by the archaeological record. Accessing dependable archaeological data from scholarly publications can often be challenging due to the variability in site ...
Solène Boisard, Eslem Ben Arous
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Middle Stone Age social connectivity: Can stone tools indicate the transmission of cultural ideas?

South African Journal of Science
Humans are unique in their ability to build complex social networks that foster cooperation, knowledge sharing and innovation. Evidence from the African Middle Stone Age provides some of the earliest signs of these connections, alongside increasingly ...
Precious Chiwara-Maenzanise, Seminew Asrat, Jayne Wilkins   +2 more
doaj   +1 more source

Local churches and the conquest of the North : elite patronage and identity in Saxo-Norman Northumbria [PDF]

, 2011
The social implications of the Saxo-Norman transition are particularly intriguing in Northumbria, where Anglian, Scandinavian, and Norman social structures, identities, and traditions of material culture converged.
McClain, A.
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

When to generalise and when to specialise? Climate change and hominin biocultural adaptability in the African early and middle stone age

Quaternary Science Advances
A growing number of authors have discussed the role of climate change in periods of important biological and cultural transition along the hominin lineage.
James Clark, Gonzalo J. Linares-Matás
doaj   +1 more source

The Use of Ochre and Painting During the Upper Paleolithic of the Swabian Jura in the Context of the Development of Ochre Use in Africa and Europe

Open Archaeology, 2018
While the earliest evidence for ochre use is very sparse, the habitual use of ochre by hominins appeared about 140,000 years ago and accompanied them ever since.
Wolf Sibylle, Conard Nicholas J., Floss Harald, Dapschauskas Rimtautas, Velliky Elizabeth, Kandel Andrew W.   +5 more
doaj   +1 more source

Behaviourally modern humans in coastal southern Africa experienced an increasingly continental climate during the transition from Marine Isotope Stage 5 to 4

Frontiers in Earth Science, 2023
Linking human technological and behavioural advances to environmental changes is challenging, as it requires a robust understanding of past climate at local scales.
Ozan Mert Göktürk, Ozan Mert Göktürk, Margit H. Simon, Margit H. Simon, Margit H. Simon, Stefan Pieter Sobolowski, Stefan Pieter Sobolowski, Zhongshi Zhang, Zhongshi Zhang, Willem Van Der Bilt, Pål Tore Mørkved, William J. D’Andrea, Karen L. van Niekerk, Karen L. van Niekerk, Christopher S. Henshilwood, Christopher S. Henshilwood, Simon J. Armitage, Simon J. Armitage, Eystein Jansen, Eystein Jansen, Eystein Jansen   +20 more
doaj   +1 more source

Stonehenge remodelled [PDF]

, 2012
We are pleased to present the latest account of the sequence of burial and construction at the site of Stonehenge, deduced by its most recent excavators and anchored in time by the application of Bayesian radiocarbon modelling.
Darvill, Timothy, Marshall, Peter, Parker Pearson, M., Wainwright, Geoff   +3 more
core   +1 more source