The long-term course of knee pain severity in middle and old age: distinct trajectories from latent class growth modelling in population cohort data (the CAS-K study and the osteoarthritis initiative (OAI)) [PDF]
Elaine Nicholls +3 more
openalex +1 more source
Correlation between long-term glycemic variability and cognitive function in middle-aged and elderly patients with type 2 diabetes mellitus [PDF]
Jingcheng Ding +6 more
openalex +1 more source
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Prognosis of symptomatic and asymptomatic middle cerebral artery disease - a long-term follow-up [PDF]
Rolf Kern +4 more
openalex +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Therapeutic efficacy of lenvatinib for patients with unresectable hepatocellular carcinoma based on the middle-term outcome. [PDF]
Fuchigami A +10 more
europepmc +1 more source
The emergent middle classes in Timor-Leste and Melanesia: conceptual issues and developmental significance [PDF]
The concept of an emerging middle class provides a useful entry point for understanding significant developmental and political transformations in Timor-Leste and Melanesia and is important for informing development policies.
John Cox, Julien Barbara, Michael Leach
core +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source

