Results 151 to 160 of about 1,400,953 (307)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Caught in the Middle? Occupancy in Multiple Roles and Help to Parents in a National Probability Sample of Canadian Adults [PDF]

This paper considers for a Canadian national probability sample of middle-aged women and men the question of how typical is the experience of being "caught in the middle" between being the adult child of elderly parents and other roles.
Carolyn J. Rosenthal, Sarah H. Matthews, Anne Martin-Matthews   +2 more
core  

Long-term healthcare utilisation, costs and quality of life after invasive group B Streptococcus disease: a cohort study in five low-income and middle-income countries. [PDF]

INTRODUCTION: There are no published data on the long-term impact of invasive group B Streptococcus disease (iGBS) on economic costs or health-related quality of life (HRQoL) in low-income and middle-income countries.
Chanda, J, Horváth-Puhó, Erzsébet, Bassat, Q, Jit, M, Lawn, Joy E, Shannon Leahy, Procter, Simon, Gonçalves, BP, Bronner P Gonçalves, Jaya Chanda, Chanda, Jaya, Santhanam, Sridhar, Libster, Romina, Abubakar, Amina, Lawn, JE, Clara Sánchez Yanotti, Horváth-Puhó, E, John, HB, Aerts, C, GBS Long-Term Outcomes LMIC Collaborative Group, Carophine Nasambu, Dangor, Ziyaad, Mark Jit, Romina Libster, Santhanam, S, Celine Aerts, Nasambu, C, Seedat, Farah, Seedat, F, Abubakar, A, Proma Paul, Yanotti, CS, Gonçalves, Bronner P, Ziyaad Dangor, Dangor, Z, Joy E Lawn, Leahy, Shannon, Procter, S, Aerts, Celine, Paul, Proma, Amina Abubakar, Hima B John, Leahy, S, Jit, Mark, John, Hima B, Simon R Procter, Bassat, Quique, Sridhar Santhanam, Paul, P, Quique Bassat, Farah Seedat, Erzsébet Horváth-Puhó, Yanotti, Clara Sánchez, Libster, R, Nasambu, Carophine   +54 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Middle-Term Evolution of Efficiency in Permeable Pavements: A Real Case Study in a Mediterranean climate. [PDF]

Int J Environ Res Public Health, 2020
Rodríguez-Rojas MI, Huertas-Fernández F, Moreno B, Martínez G.   +3 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

THE MILITARY EXPENDITURE-EXTERNAL DEBT NEXUS: NEW EVIDENCE FROM A PANEL OF MIDDLE EASTERN COUNTRIES [PDF]

This paper examines the impact of military expenditure and income on external debt for a panel of six Middle Eastern countries; namely, Oman, Syria, Yemen, Bahrain, Iran, and Jordan, over the period 1988 to 2002.
Paresh Kumar Narayan, Russell Smyth
core  

The Impact of Long‐Term Tai Chi Practice on the Trust Behavior of Middle‐Aged People

Brain and Behavior
Purpose Trust behavior is of fundamental importance for social stability and development. Middle‐aged people, owing to their abundant social resources and extensive experience, have a significant impact through their trust behavior.
Hao Hong, Xin Yu, Qiaoling Li, Bing Li, Panpan Zhang   +4 more
doaj   +1 more source