Results 131 to 140 of about 1,400,953 (307)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Security Assessment of the Smartcard Systems at Middle East Technical University

Smartcards are portable devices that can communicate wirelessly and contain microchips capable of transferring, processing or storing data. They serve practical and reliable solutions for everyday problems such as identification, access control, and ...
akçören, berkay
core  

The Perspectives of the Managers on the Space Setting Issues of the Long Term Care Instirutes

, 2011
[[abstract]]With the increase of the aging population, the number of long term care institution for older people is growing too. There are about 1,400 long term care institutions in Taiwan, and most of them are private.
Chia-ching Lin
core  

Developmental improvements in the ability to benefit from testing across middle childhood

Frontiers in Behavioral Neuroscience
Extensive behavioral research on adults has shown that retrieval practice is highly beneficial for long-term memory retention. However, limited evidence exists on the developmental course of this benefit.
Sandra Rodríguez-Gonzalo, Jaione Arnaez-Telleria, Pedro M. Paz-Alonso, Pedro M. Paz-Alonso   +3 more
doaj   +1 more source

Middle-term outcomes in renal transplant recipients with COVID-19: a national, multicenter, controlled study. [PDF]

Clin Kidney J, 2022
Oto OA, Ozturk S, Arici M, Velioğlu A, Dursun B, Guller N, Şahin İ, Eser ZE, Paydaş S, Trabulus S, Koyuncu S, Uyar M, Ural Z, Sadioğlu RE, Dheir H, Koç NS, Özer H, Durak BA, Gül CB, Kasapoğlu U, Oğuz EG, Tanrısev M, Kuzgun GŞ, Mirioglu S, Dervişoğlu E, Erken E, Görgülü N, Özkurt S, Aydın Z, Kurultak İ, Öğütmen MB, Bakırdöğen S, Kaya B, Karadağ S, Ulu MS, Güngör Ö, Bakır EA, Odabaş AR, Seyahi N, Yıldız A, Ateş K.   +40 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Travmatik deneyimler üzerine anlatılardan cinsiyetin sömürgesizleşmesi: Irak Yezidilerinin savunmasızlık, risk ve eylemlilik bağlamında bir incelemesi

, 2023
Almost nine years have passed since the Yazidi community of Iraq lived through the latest wave of gross human rights violations in their history. The long-term physical and psychosocial impacts of the genocide in August 2014 were thoroughly explored in ...
Acar, Işınsu
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Neurophysiological and neuroinflammatory adaptations to seizure activity in aging

Neurobiology of Disease
The pathophysiological impact of late-onset seizures on the brain is not well understood. Here, we investigated whether an initial pattern of generalized seizures (GS) with an electrographically defined ictal-interictal continuum, occurring at middle age
Alicia Janvier, Noemie Cresto, Cristina Nistreanu, Athenais Genin, Tristan Moujellil-Legagneur, Magalie Mathias, Mathieu Vitalis, Paolo Fabene, Edoardo Parrella, Charleine Zussy, Etienne Audinat, Laurent Givalois, Nicola Marchi   +12 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source