Results 151 to 160 of about 277,420 (291)

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, Volume 13, Issue 27, 13 May 2026.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, Volume 13, Issue 27, 13 May 2026.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

A Genetic Reporter for Visualizing Nitroreductase Activity Using Magnetic Resonance Imaging

Chemistry–Methods, Volume 6, Issue 5, May 2026.
We introduce a reporter gene technology to noninvasively visualize bacterial nitroreductase activity. Our method utilizes a magnetic resonance imaging (MRI) reporter based on aquaporin, which is fused to a destabilizing domain, resulting in their degradation (off‐state).
Jinyang Wan, Asish N. Chacko, Emrys Xu, Kiran Kuriakose, Arnab Mukherjee   +4 more
wiley   +1 more source

Engineering, Expression, Purification, and Application of Glycosaminoglycan‐Specific Antibodies

Current Protocols, Volume 6, Issue 5, May 2026.
Abstract Cluster of differentiation markers have been transformative for defining cell populations and their functional states, but recent work indicates that finer granularity can be achieved by considering the diverse heparan sulfate structures presented on proteoglycans.
Kheerthana Duraivelan, Sriram Sundaravel, Esther N. Njoroge, Robert A. Townley, Ulrich G. Steidl, Hannes E. Bülow, Steven C. Almo, Scott J. Garforth   +7 more
wiley   +1 more source

No Dye Fits All: Illuminating the Challenges of Fluorescent Extracellular Vesicle Labeling

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT The widespread use of fluorescent dyes for extracellular vesicle (EV) labeling has substantially improved our ability to trace EVs in vitro, ex vivo, and in vivo. However, interpretability of these experiments remains limited by methodological challenges, including incomplete dye removal, dye‐associated artifacts, and intrinsic EV ...
Petra Vrdoljak, Alessandro Idrovo‐Gavilanes, Thu Huyen Nguyen, Amélie Vander Cruyssen, Niké Guilbert, Cláudio Pinheiro, Martina Fabiano, Martina Pannetta, Lien Lippens, An Hendrix   +9 more
wiley   +1 more source

Flow Cytometric Detection of Biomarker Changes in CFDA‐SE‐Labelled Plasma Extracellular Vesicles Using a Rodent Pregnancy Model of Prenatal Diagnostics

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Circulating extracellular vesicles (EVs) offer a promising source of non‐invasive biomarkers for congenital disease diagnostics but robust assays for their detection are lacking. We used a rodent pregnancy model as a proxy for a prenatal diagnostics assay to test whether we could detect a difference in EV tetraspanin display between pregnant ...
Petra Adamova, Lesley Sloan, Andrew K. Powell, Iain M. Dykes   +3 more
wiley   +1 more source

Torque Teno Virus in Bronchoalveolar Lavage Fluid of Hematological Patients and Association With Pathogens

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT Torque teno virus (TTV) replication is tightly modulated by the host immune response. As such, TTV viremia has been investigated as a biomarker of immune competence for monitoring the risks of allograft rejection and opportunistic infections in solid organ transplant recipients.
Mahdi Ouafi, Camille Cordier, David Beauvais, Serge Alfandari, Marie Titécat, Romain Dubois, Frédéric Wallyn, Séverine Loridant, Fanny Vuotto, Micha Srour, Céline Berton, Valérie Coiteux, Ibrahim Yakoub‐Agha, Boualem Sendid, Didier Hober, Enagnon Kazali Alidjinou   +15 more
wiley   +1 more source

Telomere Dysfunction and Proteostasis Decline Define Distinct Pathways of Cellular Senescence in the Human Respiratory Tract

Aging Cell, Volume 25, Issue 5, May 2026.
Telomere shortening occurs with age in the respiratory epithelium, but telomere dysfunction‐induced foci (TIF) accumulate only late in life. In contrast, proteostasis decline emerges earlier and correlates with functional impairment, suggesting it may be a primary driver of cellular senescence during physiological aging.
Céline Coquette, Kamar Bouchoucha, Manon Mahieu, Stijn E. Verleden, Axelle Loriot, Kevin Norris, Duncan M. Baird, Amélie Derumier, Delphine Hoton, Laurens De Sadeleer, Arno Vanstapel, Bart M. Vanaudenaerde, Maëlle de Ville de Goyet, Bénédicte Brichard, Antoine Froidure, Wim Wuyts, Jan Van Slambrouck, Laurens J. Ceulemans, William Trigaux, Caroline Huart, Anabelle Decottignies   +20 more
wiley   +1 more source

Music Performance Improvement Support System Using a Semi-Automated Instrument-Playing Robot with Real-Time Acoustic Analysis and Habit Visualization. [PDF]

Sensors (Basel)
Tomiyoshi K, Sonoda H, Kuriyama H, Koutaki G.   +3 more
europepmc   +1 more source

Prevalence and Nationality Distribution of Known and Novel Genetic Variants in Children With Primary Ciliary Dyskinesia in the State of Qatar

Clinical Genetics, Volume 109, Issue 5, Page 937-945, May 2026.
CT scan image of a 17‐year‐old female with primary ciliary dyskinesia (PCD) showing dextrocardia and bilateral bronchiectasis. The study describes genetic mutations affecting patients with PCD in Qatar and the corresponding clinical phenotype of affected patients.
Atqah AbdulWahab, Reem Mohamed, Amani Hamid, Hadeel Alzoubi, Donald R. Love, Kelly Robinson, Ibrahim Janahi, Mutasim Abu‐Hasan   +7 more
wiley   +1 more source