Results 81 to 90 of about 4,045 (199)

An extended substrate spectrum of the proton organic cation antiporter and relation to other cation transporters

Basic &Clinical Pharmacology &Toxicology, Volume 135, Issue 6, Page 720-742, December 2024.
Abstract Most central nervous system (CNS) active drugs are organic cations, which need carrier proteins for efficient transfer through the blood–brain barrier (BBB). A genetically still unidentified proton organic cation (H+/OC) antiporter is found in several tissues, including endothelial cells of the BBB.
Cauzar Ali Khan, Nicolai Kirsch, Jürgen Brockmöller, Kyra‐Elisa Maria Redeker   +3 more
wiley   +1 more source

Immune checkpoint inhibitor‐induced autoimmune limbic encephalitis with positivity for anti‐Hu antibodies in a patient with small‐cell lung cancer: A case report and literature review

Respirology Case Reports, Volume 12, Issue 11, November 2024.
Herein, we report a case of extensive‐disease small‐cell lung cancer in a patient with immune checkpoint inhibitors ‐induced autoimmune limbic encephalitis with anti‐Hu antibody positivity complicated by memory impairment and autonomic neuropathy. Abstract In recent years, there has been an increasing number of studies on neurological symptoms induced ...
Lynn Nakahara, Shun Matsuura, Ryo Suzuki, Akira Kawamura, Takumi Nagasaki, Takafumi Masuda, Kotaro Yamada, Ryuuichi Nakamura, Toshiya Hiramatsu, Norimichi Akiyama, Kazuki Tanaka, Naoki Koshimizu, Shota Igasaki   +12 more
wiley   +1 more source

Formulation and Evaluation Immediate Release Mucoadhesive Buccal Tablet of Midodrine HCL

Asian Journal of Pharmaceutical Research and Development
This study aimed to develop and optimize immediate-release mucoadhesive buccal tablets of Midodrine Hydrochloride, intended for rapid onset of action in treating hypotensive states.
A. V. Tikait, V. Wankhade, Yukta Mhaske, S. Atram, N. Bobade, Pande S. D.   +5 more
semanticscholar   +1 more source

Updates on potential therapeutic targets in MSA

Advances in Clinical Neuroscience & Rehabilitation, 2016
Research into the genetic and molecular mechanisms underlying MSA has grown significantly in recent years. No neurorestorative treatments for MSA are available to date but there are many ongoing trials targeting α-syn pathways.
Viorica Chelban, Conceição Bettencourt, Henry Houlden   +2 more
doaj   +1 more source

Droxidopa as an effective treatment for refractory neurogenic orthostatic hypotension and reflex bradycardia in amyloid light-chain amyloidosis: a case report

Journal of Medical Case Reports, 2020
Background Droxidopa is an oral treatment for the stepwise treatment of neurogenic orthostatic hypotension from autonomic dysfunction. It has been shown to be useful predominantly with neurogenic orthostatic hypotension secondary to Parkinson’s disease ...
Annie H. Ho, Christopher W. Kinter, John Wight, Anudeep R. Neelam, David Krakow   +4 more
doaj   +1 more source

Midodrine Hydrochloride in Patients on Hemodialysis with Chronic Hypotension

Renal Failure, 1996
Chronic hypotension, volume nonresponsive, is not rare in hemodialysis patients and is usually refractory to various therapies. Midodrine hydrochloride is an alpha-mimetic drug acting directly on the peripheral alpha-receptor and increases blood pressure.
Chiu-Ching Huang, Ji-Tseng Fang
openaire   +3 more sources

Oral Midodrine Use in Weaning of Intravenous Vasopressor Infusions in Septic Shock Patients

Benha Journal of Applied Sciences
Background: Sepsis is characterized as an infection that causes potentially fatal organ malfunction as a result of a dysregulated patient response to the infection (SSC), with septic shock being a subgroup of sepsis linked with greater fatality rates due
Muhammed A.Elmorsy, Saad I.Saad, Mariam M.S.El. Wahdan   +2 more
semanticscholar   +1 more source

Comparison of the effect of midodrine versus octreotide on hemodynamic status in cirrhotic patients with ascites

Journal of Research in Medical Sciences, 2011
Background: In cirrhotic patients peripheral vasodilatation may decrease renal blood flow and subsequently raises plasma renin activity. Octreotide with several mechanisms causes peripheral arterial vasoconstriction.
Mohammad Minakari, Leila Faiiaz, Mehdi Rowshandel, Ahmad Shavakhi   +3 more
doaj  

Use of fludrocortisone for intradialytic hypotension

Kidney Research and Clinical Practice, 2018
Intradialytic hypotension during dialysis adversely affects a patient's prognosis and increases mortality. We report a case in which intradialytic hypotension that persisted after the administration of midodrine was relieved after the use of ...
Yuri Seo, Soomin Jeung, Sun-myoung Kang, Won Seok Yang, Hyosang Kim, Soon Bae Kim   +5 more
doaj   +1 more source

Combination ergotamine and caffeine improves seated blood pressure and presyncopal symptoms in autonomic failure

Frontiers in Physiology, 2014
Severely affected patients with autonomic failure require pressor agents to counteract the blood pressure fall and improve presyncopal symptoms upon standing.
Amy C Arnold, Claudia E Ramirez, Leena eChoi, Luis E Okamoto, Alfredo eGamboa, André eDiedrich, Satish R Raj, David eRobertson, Italo eBiaggioni, Cyndya Adriana Shibao   +9 more
doaj   +1 more source