Results 81 to 90 of about 7,232 (251)

Exenatide Once Weekly in the Treatment of Patients with Multiple System Atrophy

Annals of Neurology, Volume 98, Issue 5, Page 991-1003, November 2025.
Objective Exenatide, a glucagon‐like peptide‐1 (GLP‐1) receptor agonist, has neuroprotective effects in preclinical models of multiple system atrophy (MSA). We investigated these effects in a proof‐of‐concept clinical trial. Methods In this single‐center, randomized, open label trial, participants with MSA were randomly assigned (1:1) to receive ...
Nirosen Vijiaratnam, Christine Girges, Martin Wiegand, Claudia Ismail, Alexandra Lameirinhas, Alison Yarnall, Cameron Kirk, Silvia Del‐Din, Lynn Rochester, Christopher Kobylecki, Gareth Ambler, Simon Skene, Henry Houlden, Viorica Chelban, Amanda Heslegrave, Wendy Phillips, Alan Whone, Niall Quinn, Christian Lambert, Charlotte Dore, Huw R. Morris, Mathew H. Horrocks, Ji Eun Lee, Judi O'Shaughnessy, Yazhou Li, Nigel H. Greig, Sonia Gandhi, Vincenzo Libri, Dilan Athauda, Tom Foltynie   +29 more
wiley   +1 more source

Male sexual dysfunction and infertility associated with neurological disorders [PDF]

, 2011
Normal sexual and reproductive functions depend largely on neurological mechanisms. Neurological defects in men can cause infertility through erectile dysfunction, ejaculatory dysfunction and semen abnormalities.
Beckett, Nancy L., Fode, Mikkel, Krogh-Jespersen, Sheila, Lynn, Charles M., Ohl, Dana A., Sønksen, Jens   +5 more
core   +1 more source

Predictive Analysis for First Submission of Generic Drug Application for Orphan Drug Products Using Random Survival Forest

Clinical and Translational Science, Volume 18, Issue 10, October 2025.
ABSTRACT Rare diseases affect a small population of patients, resulting in low incentives for developing orphan drug products (ODPs). The United States Congress passed the Orphan Drug Act of 1983 to incentivize pharmaceutical manufacturers to develop drugs to treat rare diseases.
Robert Hopefl, Jing Wang, Abhinav Ram Mohan, Wei‐Jhe Sun, Myong‐Jin Kim, Meng Hu, Lanyan Fang   +6 more
wiley   +1 more source

Prone-Position Thoracoscopic Ligation of the Thoracic Duct for Chyle Leak Following Radical Neck Dissection in a Patient with a Right Aortic Arch [PDF]

, 2015
A chyle leak can occur as a complication after neck or chest surgery. Such a leak prolongs the hospital stay and is sometimes life-threatening. The treatment options are conservative management, interventional radiologic embolization, and surgery ...
Fujiwara, Toshiyoshi, Kagawa, Shunsuke, Kashima, Hajime, Maeda, Naoaki, Noma, Kazuhiro, Ohara, Toshiaki, Shirakawa, Yasuhiro, Tanabe, Shunsuke   +7 more
core   +1 more source

Syncope: Advances in Diagnosis and Treatment 2024

Journal of Cardiovascular Electrophysiology, Volume 36, Issue 10, Page 2671-2676, October 2025.
Vasovagal syncope advances in therapy. ABSTRACT Aim In light of many recent advances in the field of vasovagal syncope, a selective review has been undertaken of these developments. Methods Recent publications on the following topics were reviewed; understanding of vasovagal syncope pathophysiology, tilt‐testing methodology and interpretation, drug ...
Richard Sutton, Rose Anne Kenny, David G. Benditt   +2 more
wiley   +1 more source

Exercise induced collapse: neurocardiogenic syncope [PDF]

, 2009
This issue of eMedRef provides information to clinicians on the pathophysiology, diagnosis, and therapeutics of exercise induced collapse caused by neurocardiogenic ...
Chang, Tony
core  

Clinical course and prognostic factors of hepatorenal syndrome: A retrospective single-center cohort study [PDF]

, 2013
AIM: To investigate clinical and biochemical features of hepatorenal syndrome (HRS), to assess short and long-term survival evaluating potential predictors of early mortality. METHODS: Sixty-two patients with liver cirrhosis and renal failure, defined as
Almasio, P., Bonaccorso, A., Cappello, M., Craxi, A., Licata, A., Macaluso, F., Maida, M.   +6 more
core   +1 more source

Lymphoma Induced Chylothorax Complicated by Disseminated Histoplasmosis and Esophagopericardial Fistula

Clinical Case Reports, Volume 13, Issue 9, September 2025.
ABSTRACT This case report highlights the need to consider both infection and malignancy in the differential of a chylothorax, particularly in an immunosuppressed patient. The case demonstrates the challenges in treating a chylothorax, both in terms of appropriate drainage and the necessity to maintain a low‐fat diet.
Bo Liu, Kristina Aleksoniene, Sapna R. Patel, Patrick C. McKillion, Michael S. Wang   +4 more
wiley   +1 more source

Nutritional Challenges in Hemodialysis: Managing Protein Energy Wasting While Controlling Phosphorus

Clinical Case Reports, Volume 13, Issue 8, August 2025.
ABSTRACT We present a case of a 72‐year‐old male on maintenance Hemodialysis, with protein energy wasting and mild phosphoremia managed through targeted nutritional intervention that focused on high‐biological value protein intake while maintaining phosphorus control.
Jiaxiu Deng, Weixiang Luo, Xiumei Hu, Chao Yang   +3 more
wiley   +1 more source

Use of droxidopa for blood pressure augmentation after acute spinal cord injury: case reports [PDF]

Acute and Critical Care
Hypotension secondary to autonomic dysfunction is a common complication of acute spinal cord injury (SCI) that may worsen neurologic outcomes. Midodrine, an enteral α-1 agonist, is often used to facilitate weaning intravenous (IV) vasopressors, but its ...
Christopher S. Hong, Muhammad K. Effendi, Abdalla A. Ammar, Kent A. Owusu, Mahmoud A. Ammar, Andrew B. Koo, Layton A. Lamsam, Aladine A. Elsamadicy, Gregory A. Kuzmik, Maxwell Laurans, Michael L. DiLuna, Mark L. Landreneau   +11 more
doaj   +1 more source