Results 161 to 170 of about 312,838 (347)

Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study identifies mutation‐intolerant genes (MIGs), which are mutationally constrained in tumors despite normal‐tissue variability. Using miDriver, the authors pinpoint MIGs essential for tumor‐intrinsic fitness and immune evasion. Focusing on CHEK1, they show it drives tumor fitness and sculpts an immunosuppressive niche via the MIF–CD74 axis ...
Tao Wang, Hongyu Zhao, Xiaojie Sun, Yuqi Ding, Zhipeng Zhu, Xiaotong Yu, Rongyi Zhu, Dan Wang, Kailong Li, Yang Liu, Li‐Bin Wang, Xiaolu Zhao, Baojun Suo, Hongsen Bi, Peipei Zhang, Tong Liu, Fengbiao Mao   +16 more
wiley   +1 more source

ZMAT1 Promotes Osteoclastogenesis Through TRIM46 Mediated YAP1 Degradation and Inhibits Osteoblastogenesis

Advanced Science, EarlyView.
Zmat1 deficiency mitigates pathological bone loss by impairing osteoclastogenesis and promoting osteoblastogenesis. Mechanistically, in osteoclasts, Zmat1 loss relieves transcriptional repression of the E3 ligase TRIM46, promoting YAP1 degradation and inhibiting osteoclastogenic genes.
Xinyu Chang, Yijin Hou, Likun Cui, Huiqi Yu, Rong Liu, Junhao Sui, Zhong Zheng, Lu Liu, Jie Chen, Mengchen Chen, Chen Ding, Shuogui Xu, Sheng Xu, Hao Zhang   +13 more
wiley   +1 more source

National continuous professional development programmes for midwifery educators and their effectiveness in low-and-middle-income-countries: a systematic review

BMC Medical Education
Background Continuous professional development (CPD) for midwifery educators is essential. It strengthens their competencies, improves the quality of midwifery care, and ultimately helps reduce maternal and newborn mortality.
Duncan N. Shikuku, Sarah Bar-Zeev, Charles Ameh   +2 more
doaj   +1 more source

Midwives' competence : is it affected by working in a rural location? [PDF]

, 2007
Introduction: Rising health care costs and the need to consolidate expertise in tertiary services have led to the centralisation of services. In the UK, the result has been that many rural maternity units have become midwife-led.
Bryers, Helen, Caldow, Jan L., Farmer, Jane, Harris, Fiona, Hundley, Vanora, Ireland, Jillian C.M., Kiger, Alice, Tucker, Janet S., van Teijlingen, Edwin R.   +8 more
core   +1 more source

Vacancy‐Suppressed Garnet Electrolytes for Durable Solid‐State Batteries

Advanced Science, EarlyView.
A Li/O‐rich sintering strategy effectively suppresses intrinsic lithium and oxygen vacancies in cubic garnet electrolytes, yielding a dense and stable microstructure. The vacancy‐controlled electrolyte exhibits enhanced interfacial and air stability, enabling long‐term solid‐state battery cycling and providing a general design principle for defect ...
Seokjae Hong, Kwang Ho Shin, Kyoung Sun Kim, Jinhwan Kim, Jaegi Lee, Byung‐Gun Park, Won G. Hong, In Hye Kwak, Kyubin Shim, Young‐Sang Yu, Ju Young Kim, Young Hwa Jung, Min Wook Pin, Hyeon‐Jong Lee, Hojoon Kim, Dong‐Hwa Seo, Hosun Shin, Dongju Lee, Seung‐Ho Yu, Sung‐Kyun Jung, Hyungsub Kim   +20 more
wiley   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Developing a Canadian midwifery research priority framework: a Delphi consensus study

Health Research Policy and Systems
Introduction Globally, there is a commitment to evidence informed midwifery practice. In Canada, the midwifery profession has grown significantly over the past three decades, yet Canadian midwifery research lacks coordination and infrastructure ...
Beth Murray-Davis, Emma Ruby, Joanne Rack, Sofia Al-Balkhi, Lindsay Grenier, Ginny Brunton, Elizabeth K. Darling, Eileen K. Hutton, Laura Banfield, Cristina Mattison, Karyn Kaufman   +10 more
doaj   +1 more source

A Single‐Enzyme Activated CRISPR‐Cas12a Nano System via Subtly Balanced dsDNA for Kinetic‐Gated UDG Detection and Spatiotemporal Cellular Imaging

Advanced Science, EarlyView.
Kinetic‐gated CRISPR–Cas12a activation enables single‐enzyme detection and spatiotemporal imaging of UDG ABSTRACT Uracil‐DNA glycosylase (UDG) is a key enzyme in base excision repair and an important biomarker for genomic stability and disease. In many reported sensing systems, uracil excision is coupled to signal generation through additional ...
Kejun Dong, Hao Hu, Haiyun Wang, Zijia Zheng, Shuangshuang Cheng, Wan Shu, Ruisi Liu, Xiaoyan Xin, Shiyi Huang, Dingchao Qian, Xianjin Xiao, Qiang Fu, Hongbo Wang   +12 more
wiley   +1 more source

A Spatiotemporally Controlled Nanoplatform for Photothermal BRD4 Degradation Enables Synergistic Cancer Immunotherapy

Advanced Science, EarlyView.
A GSH‐responsive MOF nanoplatform acts as a Photothermolysis‐Targeting Conjugate (PTTAC). Through sophisticated step‐wise nuclear delivery, it enables NIR‐II light‐triggered photothermal degradation of BRD4. This precise strategy induces robust immunogenic cell death (ICD) and powerfully synergizes with anti‐PD‐L1 blockade to elicit a potent systemic ...
Luyi Wang, Jiasha Wu, Rui Ji, Sufeng Qiang, Yulin Shen, Yan Zuo, Shiqin Jian, Siyao Liu, Fusheng Xu, Honggang Hu, Xiaochun Hu   +10 more
wiley   +1 more source