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MIF in autoimmunity and novel therapeutic approaches
Autoimmunity Reviews, 2009 Macrophage migration inhibitory factor (MIF) is a multipotent cytokine implicated in the pathogenesis of numerous inflammatory and autoimmune disorders. Since anti-cytokine therapy is considered to be a promising therapeutic strategy, selective targeting
Ferdinando Nicoletti +2 more
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From MIF-1 to endomorphin: The Tyr-MIF-1 family of peptides
Peptides, 2007The Tyr-MIF-1 family of small peptides has served a prototypic role in the introduction of several novel concepts into the peptide field of research. MIF-1 (Pro-Leu-Gly-NH(2)) was the first hypothalamic peptide shown to act "up" on the brain, not just "down" on the pituitary.
Weihong, Pan, Abba J, Kastin
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Existence of antiopiate systems as illustrated by MIF-1/Tyr-MIF-1
Life Sciences, 1986Evidence is presented that the small peptides MIF-1/Tyr-MIF-1 are part of an endogenous antiopiate system that may function to balance the opiate system. We review the biological activity, behavioral activity, and functional effects of this proposed opiate antagonist system.
Z H, Galina, A J, Kastin
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1979
It has been known for some time that “activated” macrophages obtained from immune animals have altered morphology and metabolism, and that they show enhanced capacities to deal with a number of microorganisms (1,2). A number of these studies have shown that the lymphocyte is involved in these activation processes (3,4).
H G, Remold, A D, Mednis, P L, McCarthy
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It has been known for some time that “activated” macrophages obtained from immune animals have altered morphology and metabolism, and that they show enhanced capacities to deal with a number of microorganisms (1,2). A number of these studies have shown that the lymphocyte is involved in these activation processes (3,4).
H G, Remold, A D, Mednis, P L, McCarthy
openaire +2 more sources
Measuring MIF in Biological Fluids
2019MIF is a key regulator of host immune responses and increased levels secreted from cells, or found circulating systemically, have been implicated in the pathogenesis of many inflammatory and autoimmune disorders. Here, we describe methods for detecting and quantifying extracellular concentrations of MIF in both human- and murine-derived biological ...
Fabien B, Vincent, Tali, Lang
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