Results 211 to 220 of about 44,246 (295)

Probing pyrazolo-pyrimidines as SIRT2 inhibitors <i>via</i> molecular modelling and biological assays. [PDF]

open access: yesRSC Med Chem
Musumeci F   +12 more
europepmc   +1 more source

Advances in γδ T Cells: Cutaneous Biology and Therapeutic Potential for Skin Neoplasms

open access: yesThe Journal of Dermatology, Volume 53, Issue 10, Page 1415-1428, October 2026.
ABSTRACT γδ T cells represent an increasingly important subset of T lymphocytes in the immune response to cancer and as a platform for novel immunotherapies. The aim of this review is to synthesize recent insights into the biology and advances in therapeutic applications of γδ T cells in cutaneous malignancies, especially melanoma, within a framework ...
Simo Du   +9 more
wiley   +1 more source

A Deep‐Learning Based Biomarker of Systemic Cellular Senescence Burden to Predict Mortality and Health Outcomes

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Using 38 blood SASP proteins, a guided autoencoder‐transformer model generates a composite SASP Score that captures systemic cellular senescence burden. The score predicts mortality and age‐related diseases, outperforms individual proteins, and supports cross‐platform biomarker translation.
Shangshu Zhao   +9 more
wiley   +1 more source

The role of macrophage migration inhibitory factor (MIF) in the pathogenesis and progression of cardiovascular disease

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.
Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam   +4 more
wiley   +1 more source

Magnetic field-assisted immersion freezing preserves starch structure and quality of fresh waxy corn puree. [PDF]

open access: yesFood Chem X
Fan J   +9 more
europepmc   +1 more source

Integrative Single‐Cell Transcriptomics, Multi‐Omics Analyses, and Computational Pharmacology Reveal Macrophage Heterogeneity and the Putative THBS1‐CD36 Axis in Coronary Atherosclerosis

open access: yesChemical Biology &Drug Design, Volume 108, Issue 4, October 2026.
Single‐cell and multi‐omics analyses identified THBS1+ macrophages as a terminally differentiated, hypoxia‐adaptive population driving coronary atherosclerosis through THBS1‐CD36 signaling with lymphatic endothelial cells. Targeting CD36 with SMS121 and leveraging a THBS1+ macrophage gene signature enabled therapeutic prediction and accurate risk ...
Jianpeng Li   +4 more
wiley   +1 more source

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