Results 201 to 210 of about 44,246 (295)

Integrative Multiomics Profiling Reveals Immune Determinants of Response to Disitamab Vedotin Plus Penpulimab in HER2‐Low Breast Cancer

MedComm, Volume 7, Issue 10, October 2026.
This prospective single‐arm study evaluated neoadjuvant disitamab vedotin plus penpulimab in 20 patients with Stage II–III HER2‐low breast cancer. The regimen showed preliminary activity (pCR 20.0% intention‐to‐treat, 25.0% evaluable; ORR 56.3%) with manageable toxicity.
Xiaoxiao Liu, Yuting Song, Lei Liu, Aaron Qi Zhang, Xin Xie, Bing Wei, Ping He, Chunying Zhuang, Juanjuan Li, Xi Yan, Tinglun Tian, Xiaorong Zhong, Jie Chen, Yan Cheng, Dan Zheng, Shibao Li, Hao Wang, Ting Luo   +17 more
wiley   +1 more source

Deep learning-based spatial immunoprofiling of multiplex immunofluorescence images distinguishes tuberculosis disease states in diversity outbred mice. [PDF]

PLoS One
Sajjad U, Crossland NA, Gurcan MN, Beamer G, Niazi MKK.   +4 more
europepmc   +1 more source

A State‐Resolved Single‐Cell and Spatial Atlas Reveals IDH‐Associated Differences in Malignant and Immune Architecture in Diffuse Glioma

MedComm, Volume 7, Issue 10, October 2026.
Single‐cell and spatial transcriptomic profiling of 69 adult‐type diffuse gliomas revealed seven recurrent malignant cell states. GBMs were enriched for astrocyte‐like progenitor, hypoxic, and proliferative states, with higher T‐ and myeloid‐cell infiltration but transcriptional immune suppression.
Ashraf Zaman, Emily Holton, Madhavi Pandya, Genevieve Shillington, Cecile Escher, Kavitha Krishna Sudhakar, Agota Tuzesi, Ashish Mehta, Eric Lam, Rachael Zekanovic, Michael Sughrue, Charlie Teo, Jacky Yeung, Walter Muskovic, Joseph E. Powell   +14 more
wiley   +1 more source

Pan-tumor spatial transcriptomics reveals conserved properties of tumor organization. [PDF]

Cell Rep Med
Behera V, Guzzetta A, Giba H, Pen UY, Di Lello A, Pandey B, Doran BA, Esposito A, Pezeshk A, Husain A, Bestvina CM, Kline J, Garassino MC, Raman AS.   +13 more
europepmc   +1 more source

Cancer Cell Metastasis: From Molecular Mechanisms to Therapeutic Strategies

MedComm, Volume 7, Issue 10, October 2026.
The schematic representation of intrinsic and extrinsic influences of cancer cell metastasis. Genomic evolution of metastatic tumor cells (MTCs) promotes their metastatic phenotypes and reconstruct the primary tumor microenvironment. During MTCs migration along different routes (blood circulation, lymphatic vessels, and perineuronal spaces), the ...
Yupeng Zhao, Wenchao Xu, Yibo Wang, Haoran Huang, Yu Su, Li Zhou, Jianzhou Liu, Junchao Guo   +7 more
wiley   +1 more source

Alveolar Macrophages: Development, Respiratory Homeostasis, Signal Pathways, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
Alveolar macrophages: development, respiratory homeostasis, signal pathways, diseases, and therapeutic opportunities: During embryonic development, fetal progenitors migrate to the developing lungs via a CX3CR1‐dependent mechanism to establish the TrAM pool.
Sihan Yang, Ruomeng Li, Chuanjiang Yu, Jing Li, Xikun Zhou   +4 more
wiley   +1 more source

Neuron-Derived MIF Engages VCAM1 to Fuel a Self-Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer. [PDF]

Adv Sci (Weinh)
Li X, Zhai Z, Yu H, Qiu R, Li F, Xiao L, Huang B, Liu H, He J, Cai B, Chen J, Yu J, Li G, Chen T.   +13 more
europepmc   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Compartmentalized B cell-microglia crosstalk drives ischemic white matter demyelination. [PDF]

Nat Commun
Xu L, Yang S, Zhu L, Mei Z, Li W, Chu Y, Pang X, Zhang H, Lu S, Chen L, He J, Tian M, Liu Y, Zhou L, Shang K, Xiao J, Wang W, Tian D, Qin C.   +18 more
europepmc   +1 more source

Revisiting the Association of Pesticide Exposure and Parkinson's Disease: Systematic Review and Meta‐Analysis

Environmental Toxicology, Volume 41, Issue 10, Page 875-888, October 2026.
ABSTRACT The association between pesticide exposure and Parkinson's disease (PD) is substantial, but heterogeneity in methodology and lack of categorization according to the type of exposure and pesticide classes in previous meta‐analyses impair the interpretation of data. This study aims to update evidence of the association between pesticide exposure
Pedro Henrique Passos da Silva, Jadson Silva Abreu, Rafael Sidônio Gibson Gomes, Hemengella Karyne Alves Oliveira, Artur F. S. Schuh, Ignacio F. Mata, Bruno Lopes Santos‐Lobato   +6 more
wiley   +1 more source