Results 121 to 130 of about 29,702 (243)

Combined Analysis of Mifepristone for Psychotic Depression: Plasma Levels Associated With Clinical Response.

Biological Psychiatry, 2018
BACKGROUND Patients with psychotic depression exhibit elevated cortisol levels. Competitively antagonizing cortisol at the glucocorticoid receptor with mifepristone demonstrated therapeutic benefit in early studies of patients with psychotic depression ...
Thaddeus S. Block, H. Kushner, N. Kalin, C. Nelson, J. Belanoff, A. Schatzberg   +5 more
semanticscholar   +1 more source

MIFEPRISTONE TREATMENT FOR MILD AUTONOMOUS CORTISOL SECRETION DUE TO ADRENAL ADENOMAS: A PILOT STUDY.

Endocrine Practice, 2019
Objective Adrenal incidentalomas are increasingly detected with the widespread use of thoracic and abdominal imaging. The most common secretory syndrome in adrenal nodules is autonomous cortisol secretion (ACS).
Regina Belokovskaya, A. Ravikumar, Dushyanthy Arumugam, S. Izadmehr, Gillian M. Goddard, E. Geer, A. Levine   +6 more
semanticscholar   +1 more source

Mifepristone and rapamycin have non-additive benefits for life span in mated female Drosophila

Fly
The drugs mifepristone and rapamycin were compared for their relative ability to increase the life span of mated female Drosophila melanogaster. Titration of rapamycin indicated an optimal concentration of approximately 50 μM, which increased median life
Gary N. Landis, Britta Baybutt, Shoham Das, Yijie Fan, Kate Olsen, Karissa Yan, John Tower   +6 more
doaj   +1 more source

A new trick for an old dog: The application of mifepristone in the treatment of adenomyosis

Journal of Cellular and Molecular Medicine, 2019
Adenomyosis is also called internal endometriosis and affects about 20% of reproductive‐aged women. It seriously reduces life quality of patients because current drug therapies face with numerous challenges. Long‐term clinical application of mifepristone
Xuan Che, Jianzhang Wang, Jiayi He, Qin Yu, Wenting Sun, Shuyi Chen, G. Zou, Tiantian Li, Xinyue Guo, Xin-mei Zhang   +9 more
semanticscholar   +1 more source

Implementation of mifepristone medical abortion in Canada: pilot and feasibility testing of a survey to assess facilitators and barriers

Pilot and Feasibility Studies, 2019
BackgroundDirect primary care provision of first-trimester medical abortion could potentially address inequitable abortion access in Canada. However, when Health Canada approved the combination medication Mifegymiso® (mifepristone 200 mg/misoprostol 800 ...
Courtney Devane, R. Renner, S. Munro, E. Guilbert, S. Dunn, M. Wagner, W. Norman   +6 more
semanticscholar   +1 more source

Pharmacokinetics and bioequivalence of two formulations of mifepristone tablets in healthy Chinese subjects under fasting conditions: a single-center, open, randomized, single-dose, double-period, two-sequence, crossover trial

Frontiers in Pharmacology
ObjectiveA bioequivalence (BE) study was performed to evaluate the pharmacokinetics, safety, and bioequivalence of two formulations of mifepristone tablets in healthy Chinese volunteers under fasting conditions.MethodsA single-center, open, randomized ...
Yufeng Yan, Xiaoshan Zhu, Ping Dong, Cheng Liu, Lingqing Lu, Liyan Zeng, Guiying Chen, Xianmin Meng, Xianmin Meng, Min Liu   +9 more
doaj   +1 more source

Mifepristone [PDF]

Reactions Weekly, 2020
  +4 more sources

Waiting for Mifepristone [PDF]

, 2012
Physically, it is just a little white pill. But oh, what it could do: take abortion out of easily-identified clinics and disburse it to hospitals and doctor's offices, making what is so often called a "a private choice" actually private.
Wilson, Lisa A.
core  

Off-label use of misoprostol in gynaecology [PDF]

, 2015
Clinical use of drugs is approved for specified clinical indication, route of administration, dose and population group. Off-label prescribing of a registered medicine occurs outside of these parameters and may be justified by pharmacology and physiology,
Agatonovic-Kustrn, S., Turner, J. V., Ward, H. R. G.   +2 more
core  

Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor

Biomedicines
Background/objective: The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation, such as mental
Ovinuchi Ejiohuo, Donald Bajia, Joanna Pawlak, Aleksandra Szczepankiewicz   +3 more
doaj   +1 more source