Results 111 to 120 of about 17,319 (251)

Pharmacokinetics and bioequivalence of two formulations of mifepristone tablets in healthy Chinese subjects under fasting conditions: a single-center, open, randomized, single-dose, double-period, two-sequence, crossover trial

open access: yesFrontiers in Pharmacology
ObjectiveA bioequivalence (BE) study was performed to evaluate the pharmacokinetics, safety, and bioequivalence of two formulations of mifepristone tablets in healthy Chinese volunteers under fasting conditions.MethodsA single-center, open, randomized ...
Yufeng Yan   +9 more
doaj   +1 more source

Discovery of non-steroidal mifepristone mimetics:pyrazoline-based PR antagonists

open access: yes, 2005
Mifepristone is a non-selective antagonist of 3-oxosteroid receptors with both abortifacient and anti-endometriotic activities. Non-steroidal mimetics of mifepristone and progesterone are important templates for modulation of the progesterone receptor ...
Gray, David W.; id_orcid   +9 more
core   +1 more source

What is the impact of contraceptive methods and mixes of contraceptive methods on contraceptive prevalence, unmet need for family planning, and unwanted and unintended pregnancies? [PDF]

open access: yes, 2013
Background - In many low-and middle-income countries, there is high maternal, infant and child mortality due in part to low contraceptive use and high unmet need for family planning.
Ogollah, Reuben   +13 more
core  

Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor

open access: yesBiomedicines
Background/objective: The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation, such as mental
Ovinuchi Ejiohuo   +3 more
doaj   +1 more source

Resetting the Stress System with a Mifepristone Challenge

open access: yes, 2019
Psychotic depression is characterized by elevated circulating cortisol, and high daily doses of the glucocorticoid/progesterone antagonist mifepristone for 1 week are required for significant improvement.
Dalm, S.   +4 more
core   +1 more source

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