Results 101 to 110 of about 4,386 (137)

Mifepristone for cervical ripening and induction of labour [PDF]

, 2018
Background: The study was aimed to evaluate the efficacy of Mifepristone for induction of labour and in improving the Bishop score at term. The study also aimed to assess induction delivery interval and maternal and fetal outcomes with Mifepristone ...
G., Lata, R., Mittal, S., Kumar, N., Rana   +3 more
core   +1 more source

Pharmacokinetics and bioequivalence of two formulations of mifepristone tablets in healthy Chinese subjects under fasting conditions: a single-center, open, randomized, single-dose, double-period, two-sequence, crossover trial

Frontiers in Pharmacology
ObjectiveA bioequivalence (BE) study was performed to evaluate the pharmacokinetics, safety, and bioequivalence of two formulations of mifepristone tablets in healthy Chinese volunteers under fasting conditions.MethodsA single-center, open, randomized ...
Yufeng Yan, Xiaoshan Zhu, Ping Dong, Cheng Liu, Lingqing Lu, Liyan Zeng, Guiying Chen, Xianmin Meng, Xianmin Meng, Min Liu   +9 more
doaj   +1 more source

Mifepristone for preoperative treatment of uterine leiomyoma

, 2011
AIM: To explore the clinical impact and its molecular regulation on uterine leiomyomas in preoperative treatment with mifepristone, a progesterone receptor modulator (PRM).BACKGROUND: Uterine leiomyomas are highly prevalent in fertile women, increasing ...
Mikael Engman (18674752)
core   +1 more source

Study of effects of mifepristone on full-term pregnancies

, 2020
The induction of labour is required for various indications in obstetrics. Various regimens and drugs are advocated for use in labour induction. Mifepristone is one such drug which has a definite role in first and second-trimester pregnancy terminations.
Uday Bhanu Rana, Priyanka Sharma, Kushla Pathania   +2 more
core   +1 more source

Discovery of non-steroidal mifepristone mimetics:pyrazoline-based PR antagonists

, 2005
Mifepristone is a non-selective antagonist of 3-oxosteroid receptors with both abortifacient and anti-endometriotic activities. Non-steroidal mimetics of mifepristone and progesterone are important templates for modulation of the progesterone receptor ...
Gray, David W.; id_orcid, Stewart, Eugene L., Hoekstra, William J., Thompson, Scott K., Kallander, Lara S., Williams, Shawn P., Madauss, Kevin P., Jones, David G., Liang, Xi, Noe, Robert A.   +9 more
core   +1 more source

Asoprisnil as a Novel Ligand Interacting with Stress-Associated Glucocorticoid Receptor

Biomedicines
Background/objective: The glucocorticoid receptor (GR) is critical in regulating cortisol production during stress. This makes it a key target for treating conditions associated with hypothalamic–pituitary–adrenal (HPA) axis dysregulation, such as mental
Ovinuchi Ejiohuo, Donald Bajia, Joanna Pawlak, Aleksandra Szczepankiewicz   +3 more
doaj   +1 more source

Progesterone receptor antagonism by mifepristone impairs trophoblast stemness and promotes apoptosis through upregulation of PDCD4

Cell & Bioscience
Background Trophoblast cells are a critical component of retained products of conception (RPOC). While mifepristone is widely used as a non-invasive treatment for RPOC, its precise molecular mechanisms in trophoblast regulation remain poorly defined ...
Jie Zhou, Li Yan, Yamei Li, Suming Huang, Qicheng Lan, Duo Zhang, Qian Zhu, Xiaoya Zhao, Jian Zhang   +8 more
doaj   +1 more source

Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in Female Drosophila

Cells
Mating in female Drosophila melanogaster causes midgut hypertrophy and reduced lifespan, and these effects are blocked by the drug mifepristone. Eip75B is a transcription factor previously reported to have pleiotropic effects on Drosophila lifespan ...
Gary N. Landis, Hans S. Bell, Oscar K. Peng, Yijie Fan, Karissa Yan, Britta Baybutt, John Tower   +6 more
doaj   +1 more source

Syntheses and Antigestagenic Activity of Mifepristone Derivatives

, 2016
A series of mifepristone derivatives with different “linker groups” in position 4′ of the phenyl ring in the 11β-position of the steroid scaffold (2−41) have been synthesized.
Rainer Strommer (2387032), Sonja Sturm (1583488), Ernst Haslinger (2387041), Gerhard F. Ecker (221470), Christoph Seger (1583491), Claudia Hödl (2387035), Olaf Kunert (404986), Hans-Wolfgang Schramm (2387029), Rudolf Steiner (2387044), Katrin Raunegger (2387038), Wolfgang S. L. Strauss (294234)   +10 more
core   +1 more source

Mifepristone-related foetal cardiac adverse events: findings from the postmarketing safety reports

Journal of Obstetrics and Gynaecology
Background This study aimed to analyse the clinical characteristics of mifepristone-associated congenital and foetal cardiac adverse events using data from the U.S.
Ran Liu, Jihong Wang, Qiong Wang, Yi Zhang, Fengjuan Yuan   +4 more
doaj   +1 more source