Results 121 to 130 of about 2,994,325 (382)

Migraine and Bipolar Disorder

Journal of Neurology & Neurophysiology, 2018
The co-morbidity between migraine and bipolar disorders is well documented in numerous clinical and epidemiological studies, but the aetiologies are currently unknown. Many Authors have suggested some pathophysiological mechanisms in common. This co-morbidity, moreover, influences the outcome of both disorders.
Ottavio Di Marco, Carmine Di Marco, Stefania Di Mauro   +2 more
openaire   +2 more sources

Serotonergic Modulators in Alzheimer's Disease: A Hope in the Hopeless Condition

Chemistry &Biodiversity, EarlyView.
ABSTRACT Alzheimer's disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Najlaa Hamed Almohmadi, Hayder M. Al‐Kuraishy, Ali I. Al‐Gareeb, Ali K. Albuhadily, Morkoss M. Fakhry, Athanasios Alexiou, Marios Papadakis, Gaber El‐Saber Batiha   +7 more
wiley   +1 more source

Inflammo-immune perspective on the association of eight migraine risk factors with migraine: a multi-omics Mendelian randomization study

Frontiers in Neurology
BackgroundMigraine risk factors are associated with migraine susceptibility, yet their mechanisms are unclear. Evidence suggests a role for inflammatory proteins and immune cells in migraine pathogenesis.
Jiaxi Zhao, Rong Chen, Mengqi Luo, Hongping Gong, Kaixin Li, Kaixin Li, Qian Zhao   +6 more
doaj   +1 more source

Association Between Vestibular Migraine and Migraine Headache: Yet to Explore. [PDF]

, 2020
ObjectivesTo evaluate if patients with a diagnosis of vestibular migraine (VM) by the International Classification of Headache Disorders (ICHD) criteria have meaningful differences in symptomatology and disease characteristics when compared to patients ...
Abouzari, Mehdi, Djalilian, Hamid R, Goshtasbi, Khodayar, Lin, Harrison W, Moshtaghi, Omid, Tan, Donald   +5 more
core  

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Factors associated with acute medication overuse in chronic migraine patients [PDF]

Einstein (São Paulo), 2012
Objective: To evaluate the prevalence of psychiatric disorders inpatients diagnosed with chronic migraine with and without acutemedication overuse. Methods: Seventy-two volunteers were recruitedfrom a Family Health Program of the Paraisópolis community ...
Vera Zukerman Guendler, Juliane Prieto Peres Mercante, Reinaldo Teixeira Ribeiro, Eliova Zukerman, Mario Fernando Prieto Peres   +4 more
doaj  

Understanding the nature of psychiatric comorbidity in migraine: a systematic review focused on interactions and treatment implications

The Journal of Headache and Pain, 2019
Background Migraine is a highly prevalent and disabling neurological disorder which is commonly linked with a broad range of psychiatric comorbidities, especially among subjects with migraine with aura or chronic migraine.
Thomas Dresler, Salvatore Caratozzolo, Kaat Guldolf, Jana-Isabel Huhn, Carmela Loiacono, Triinu Niiberg-Pikksööt, Marta Puma, Giorgia Sforza, Anna Tobia, Raffaele Ornello, Gianluca Serafini, on behalf of the European Headache Federation School of Advanced Studies (EHF-SAS)   +11 more
doaj   +1 more source

Migraine headache: Is it only a neurological disorder? Links between migraine and cardiovascular disorders

Trends in Cardiovascular Medicine, 2020
Migraine headache (MH) is a common disorder affecting millions of people in the United States. MH is substantially more prevalent in women compared to men. An association between migraine with or without aura and risk of cardiovascular disease (CVD) has been extensively reported. There are several proposed theories that may explain the pathophysiologic
Dandan Chen, Monica Willis-Parker, Gina Price Lundberg   +2 more
openaire   +3 more sources

PACAP and migraine headache: immunomodulation of neural circuits in autonomic ganglia and brain parenchyma. [PDF]

, 2018
The discovery that intravenous (IV) infusions of the neuropeptide PACAP-38 (pituitary adenylyl cyclase activating peptide-38) induced delayed migraine-like headaches in a large majority of migraine patients has resulted in considerable excitement in ...
Akerman, Simon, Baca, Serapio M, Waschek, James A   +2 more
core   +2 more sources

Pharmacokinetics, Safety, and Skin Irritation and Sensitization Potential of Clascoterone Cream in Early‐Phase Clinical Study Participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Clascoterone is an androgen receptor inhibitor approved for the treatment of acne vulgaris in patients 12 years of age and older. Here, we report results of 5 phase 1 studies that assessed the pharmacokinetics (PK), safety, and skin irritation and sensitization potential of clascoterone cream 1% in healthy participants and patients with acne ...
Andrea Francesco Daniele Di Stefano, Milko Massimiliano Radicioni, Gerhard Garhöfer, Martina Cartwright, Markus Müller, Iris Kopeloff, Luigi Moro, Nicholas Squittieri, Alessandro Mazzetti   +8 more
wiley   +1 more source