Results 161 to 170 of about 59,829 (305)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Hormonal Contraception and Vestibular Disorders: A Narrative Review of Clinical Implications, Diagnostic Challenges, and Evidence Gaps. [PDF]

Cureus
Castillo-Bustamante M, Whelan DM, Martin L.   +2 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Drugs that act on both G protein‐coupled receptors (GPCRs) and kinases: potentiation of effects, side effects and general aspects of drug pleiotropy

British Journal of Pharmacology, EarlyView.
Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren, Aleksandr Sokolov, Flavio Ballante, Robert Fredriksson, Francisco Lagunas‐Rangel, Alexander S. Hauser, Stefan Knapp, Jörgen Jonsson, Helgi B. Schiöth   +8 more
wiley   +1 more source

Caffeine and Headache: Exploring the Multifaceted Relationship. [PDF]

Brain Behav
Hussein M, Hassan A, Al-Azayem SA, Thuraiaiyah J, Schytz HW, Nasser AMA, Magdy R.   +6 more
europepmc   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source

Emotion Regulation and Temperament Characteristics in Children and Adolescents Diagnosed With Migraine and Tension-Type Headache. [PDF]

Psychiatry Investig
Ferahkaya H, Bilgiç A, Türker M, Özdemir FMA, Keskin DM.   +4 more
europepmc   +1 more source

OnabotulinumtoxinA for chronic migraine: a critical appraisal

, 2015
Rubesh Gooriah, Fayyaz Ahmed Department of Neurology, Hull Royal Infirmary, Kingston Upon Hull, UK Abstract: Chronic migraine (CM) is a severe disabling condition with a few available evidence-based management options.
Ahmed F, Gooriah R
core  

Editorial: Migraine and vascular disorders

Frontiers in Pain Research, 2022
openaire   +4 more sources

The prevalence of comorbid migraine in multiple sclerosis: do multiple sclerosis and migraine really coexist? [PDF]

J Oral Facial Pain Headache
Kępczyńska K, Sochań P, Bednarczyk N, Sochań PJ, Domitrz W, Kochanowski J, Domitrz I.   +6 more
europepmc   +1 more source