Results 81 to 90 of about 37,957 (313)

Human hypoxia models in aerospace medicine: Potential applications for human pharmacological research

British Journal of Clinical Pharmacology, EarlyView.
Aerospace medicine required controlled terrestrial models to investigate influences of altered atmosphere conditions, such as hypoxia, on human health and performance. These models could potentially be expanded to encompass disease conditions or treatment targets regulated through hypoxia or hypercapnia.
Titiaan E. Post, Cayla Denney, Adam Cohen, Jens Jordan, Ulrich Limper   +4 more
wiley   +1 more source

A study on the therapeutic effects of Topiramate according to the types of migraine [PDF]

Korean Journal of Pediatrics, 2010
Purpose : The purpose of this study was to evaluate whether the therapeutic effects of topiramate differ according to the types of migraine. Methods : We recruited 38 children and adolescents with migraine who had been treated with topiramate. The effect
Jun Hwa Lee, Kyung Lae Cho
doaj   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC) [PDF]

, 2017
Several data indicate that migraine, especially migraine with aura, is associated with an increased risk of ischemic stroke and other vascular events. Of concern is whether the risk of ischemic stroke in migraineurs is magnified by the use of hormonal ...
Aegidius, Karen Lehrmann, Bitzer, Johannes, Canonico, Marianne, Kurth, Tobias, Merki-Feld, Gabriele S., Sacco, Simona   +5 more
core   +1 more source

Arterial spin labeling MRI applied to migraine: current insights and future perspectives

The Journal of Headache and Pain, 2023
Introduction Advanced neuroimaging techniques have extensively contributed to elucidate the complex mechanisms underpinning the pathophysiology of migraine, a neurovascular disorder characterized by episodes of headache associated with a constellation of
Antonio Russo, Marcello Silvestro, Alessandro Tessitore, Ilaria Orologio, Alessandro Pasquale De Rosa, Rosa De Micco, Gioacchino Tedeschi, Fabrizio Esposito, Mario Cirillo   +8 more
doaj   +1 more source

Cathodal Occipital tDCS is unable to modulate The Sound Induced Flash Illusion in migraine [PDF]

, 2019
Migraine is a highly disabling disease characterized by recurrent pain.Despite an intensive effort, mechanisms of migraine pathophysiology, still represent an unsolved issue.
Filippo Brighina, Giuseppe Cosentino, Giuseppe Giglia, GIUSEPPE SALEMI, Massimo Gangitano, Nadia Bolognini, Simona Maccora   +6 more
core   +1 more source

Migraine with visual aura is a risk factor for incident atrial fibrillation

Neurology, 2018
Objective Migraine with visual aura is associated with cardioembolic stroke risk. The aim of this study was to test association between migraine with visual aura and atrial fibrillation (AF), in the Atherosclerosis Risk in Communities study.
S. Sen, X. Androulakis, Viktoriya Duda, Á. Alonso, L. Chen, E. Soliman, J. Magnani, Tushar Trivedi, A. Merchant, R. Gottesman, W. Rosamond   +10 more
semanticscholar   +1 more source

The human photosensitive epilepsy model for clinical proof‐of‐principle trials of novel antiseizure medications. 1. Use of the EEG in drug development and characteristics of the model

Epilepsia, EarlyView.
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof‐of‐principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalography (EEG) response (PPR) as a surrogate for seizures, is currently the only human model that allows POP trials of investigational compounds after ...
Dorothée Kasteleijn‐Nolst Trenité, Wolfgang Löscher   +1 more
wiley   +1 more source

Migraine aura, a predictor of near-death experiences in a crowdsourced study [PDF]

PeerJ, 2019
Background Near-death experiences (NDE) occur with imminent death and in situations of stress and danger but are poorly understood. Evidence suggests that NDE are associated with rapid eye movement (REM) sleep intrusion, a feature of narcolepsy. Previous
Daniel Kondziella, Markus Harboe Olsen, Coline L. Lemale, Jens P. Dreier   +3 more
doaj   +2 more sources

Migraine with brainstem aura: defining the core syndrome.

Brain : a journal of neurology, 2019
Migraine with brainstem aura is a rare subtype of migraine with aura. Although this entity has been known for many years, its diagnosis and even its existence are still a matter of debate.
N. Yamani, M. A. Chalmer, J. Olesen
semanticscholar   +1 more source