Results 51 to 60 of about 188,331 (308)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ethical framework and inclusivity: research mechanics of difficult-to-reach migrants in civil military context

Journal of International Humanitarian Action
In the midst of humanitarian crises, understanding and helping hard-to-reach migrant communities, is a major challenge for researchers. This article addresses the ethical framework and dimensions of inclusivity associated with researching such ...
A. K. M. Ahsan Ullah
doaj   +1 more source

Major Stressors and Coping Strategies of Internal Migrant Workers During the COVID-19 Pandemic: A Qualitative Exploration

Frontiers in Psychology, 2021
COVID-19 forced lockdown in India, leading to the loss of job, crisis of food, and other financial catastrophes that led to the exodus migration of internal migrant workers, operating in the private sector, back to their homes.
Akanksha Srivastava, Yogesh Kumar Arya, Shobhna Joshi, Tushar Singh, Harleen Kaur, Himanshu Chauhan, Abhinav Das   +6 more
doaj   +1 more source

Labor Market Challenges in Europe With Respect to the Migrant Crisis [PDF]

, 2016
Advocates and opponents of European refugee policy have disagreed often over the economic impact of new asylum seekers. This paper analyzes characteristic qualities of the European labor market and how they relate to the recent changes in migration from ...
Segerstrom, Thomas M.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Современные геодемографические проблемы Евросоюза и миграционный кризис 2010-х годов=Current Geodemographic Problems in the European Union and Migration Crisis of the 2010s [PDF]

Балтийский регион, 2017
This article demonstrates the effect of the 2010s migration crisis has had on the demographic development of the European Union. Employing statistics and map­ping, the study argues that the demographic development of EU states is not affected by either ...
Martynov Vasily L., Sazonova Irina E.
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Divided Diasporas: Southern Africans in Canada [PDF]

, 2013
The protracted economic and political crisis in Zimbabwe led directly to a major increase in mixed migration flows to South Africa. Migrants were drawn from every sector of society, all education and skill levels, equal numbers of both sexes, and all ...
Caesar, Mary, Chikanda, Abel, Crush, Jonathan, Eberhardt, Cassandra, Hill, Ashley, Pendleton, Wade, Ramachandran, Sujata   +6 more
core   +1 more source

Migration as a Political and Public Phenomenon: The Case of Poland [PDF]

, 2017
Publication within the project “The V4 towards migration challenges in Europe.
Kobierecka, Anna, Kobierecki, Michał, Rulski, Michał, Łoś, Robert   +3 more
core   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source