Results 51 to 60 of about 1,506,509 (302)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Major Stressors and Coping Strategies of Internal Migrant Workers During the COVID-19 Pandemic: A Qualitative Exploration

Frontiers in Psychology, 2021
COVID-19 forced lockdown in India, leading to the loss of job, crisis of food, and other financial catastrophes that led to the exodus migration of internal migrant workers, operating in the private sector, back to their homes.
Akanksha Srivastava, Yogesh Kumar Arya, Shobhna Joshi, Tushar Singh, Harleen Kaur, Himanshu Chauhan, Abhinav Das   +6 more
doaj   +1 more source

The Migrant Crisis and Refugees – a Crisis of EU Solidarity

Polish Review of International and European Law, 2020
The migration and refugee crisis in Europe 2015–2016 has posed a great challenge to the international and European community in terms of solidarity with refugees, forced migrants and countries most vulnerable to large waves of migration. It would seem that solidarity in the European Union is well established, but it turned out that the crisis situation
openaire   +2 more sources

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Rape Crisis Centre 1994 statistics and financial summary [PDF]

, 1995
I have audited the financial statements above and opposite in accordance with Auditing Standards. In my opinion, the financial statements give a true and fair view of the statement of the company's affairs at 31 st December 1994, and of its results ...
Rape Crisis Centre.
core  

Crisis and the strategies of immigrants in Spain: the Latin accent

Revista CIDOB d'Afers Internacionals, 2014
The crisis has started a new migration cycle in Spain. As an effect of the restrictive measures taken and the depth of the crisis, migrant inflows have reduced and outflows have increased, the latter especially among Latin Americans.
Francisco Torres Pérez
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Современные геодемографические проблемы Евросоюза и миграционный кризис 2010-х годов=Current Geodemographic Problems in the European Union and Migration Crisis of the 2010s [PDF]

Балтийский регион, 2017
This article demonstrates the effect of the 2010s migration crisis has had on the demographic development of the European Union. Employing statistics and map­ping, the study argues that the demographic development of EU states is not affected by either ...
Martynov Vasily L., Sazonova Irina E.
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source