Results 91 to 100 of about 67,215 (309)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Migrant labor brochure from the Office of Migrant Education

, 1960
Undated brochure from the Office of Migrant Education in Trenton, New Jersey, entitled: 'We won't let them down just because they're down on the farm.' Discusses the needs of children of migrant laborers for education, health, nutrition, and social ...
Office of Migrant Education (N.J.)
core   +1 more source

Life-course and population health perspectives to fill gaps in migrant health research

, 2020
This article highlights categories and dichotomies used in the study of the health of migrants, including migrant motivation, migrant type, pre- and post-migration time periods, and health as biomedically or socially determined.
Fujishiro, Kaori, Ahonen, Emily Q.
core   +1 more source

Migration, Urbanism and Health: Moving Toward Systems-Informed Policy and Practice [version 2; peer review: 1 approved, 2 approved with reservations]

F1000Research
Migration and displacement are pivotal determinants of urban health, influencing both direct and indirect health outcomes. Migrants may face unique health risks, often exacerbated by economic, social, and environmental factors encountered during transit ...
Karen Lau, Furio Honsell, Sally Hargreaves, Rita Sà Machado, Palmira Immordino, Cathy Zimmerman, Anna Ziersch, Yang Xiao, Irene Torres, Stefania Pascut   +9 more
doaj   +1 more source

Health equity and migrants in the Greater Mekong Subregion

Global Health Action, 2017
Background: Migrant health is receiving increasing international attention, reflecting recognition of the health inequities experienced among many migrant populations and the need for health systems to adapt to diverse migrant populations. In the Greater
Celia McMichael, Judith Healy
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

International migrant workers, heat exposure, and climate change: a systematic review of health risks and protective interventions

BMC Global and Public Health
Background International migrant workers, representing 170 million people globally, often face hazardous working conditions, including extreme heat exposure.
Lara Van der Horst, Oumnia Bouaddi, Sarah Williams, Meg Jago, Karen Lau, Ben Furber, Amirah Zafirah Zaini, Engy Mohamed El-Ghitany, Tharani Loganathan, Andreas D. Flouris, Davide J. Testa, Cathy Zimmerman, Sally Hargreaves, Consortium for Migrant Worker Health   +13 more
doaj   +1 more source

Defining travel-associated cases of enteric fever

Journal of Infection and Public Health, 2014
Summary: There is no internationally recognized case-definition for travel-associated enteric fever in non-endemic countries. This study describes the patterns of case reporting between 2007 and 2011 as travel-associated or not from the surveillance data
Joanne Freedman, Lorraine Lighton, Jane Jones   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Mental health disparities by sex: unravelling determinants and changes in the refugee resettlement process over a decade

Epidemiology and Psychiatric Sciences
Aims Significant sex disparities in mental health have been observed amongst resettled refugees, yet how these disparities and their determinants evolve over time remains unclear.
Xinyan Bu, Meng Zheng, Andre M.N. Renzaho, Thomas P. Nguyen, Shameran Slewa-Younan, Shiyu Feng, Xuezhi Liang, Wen Chen   +7 more
doaj   +1 more source